Volume 31, Issue 4 (April 2026)

Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina

Open Access 27 Apr 2026Original Research

Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina

Ting-ting Zhao, Ming-kai Chang, Bai-yun Shen, Hao-ran Guo, Yu-tong Han, Wen-fei Wang

Front. Biosci. (Landmark Ed) 2026, 31(4), 47702; https://doi.org/10.31083/FBL47702

Abstract

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195

Context-Dependent Modulation of Macrophage Plasticity by Cordycepin Drives Tumor Regression in Melanoma

Open Access 27 Apr 2026Original Research

Context-Dependent Modulation of Macrophage Plasticity by Cordycepin Drives Tumor Regression in Melanoma

Jihae Lim, Donglan Piao, Jio Kang, Suh Jin Yoon, Hyun Ji Lee, Isoo Youn, Eun Kyoung Seo, Eun Sook Hwang

Front. Biosci. (Landmark Ed) 2026, 31(4), 52067; https://doi.org/10.31083/FBL52067

Abstract

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507

Retraction: Li et al. MEG3 Targets miR-184 and Wnt/β-catenin and Modulates Properties of Osteosarcoma. Frontiers in Bioscience (Landmark Edition). 2020; 25: 1901–1912

Open Access 27 Apr 2026Retraction

Retraction: Li et al. MEG3 Targets miR-184 and Wnt/β-catenin and Modulates Properties of Osteosarcoma. Frontiers in Bioscience (Landmark Edition). 2020; 25: 1901–1912

Frontiers in Bioscience-Landmark Editorial Office

Front. Biosci. (Landmark Ed) 2026, 31(4), 53323; https://doi.org/10.31083/FBL53323

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237

Calcitonin Receptor is a Novel Biomarker for NF-κB-Mediated Cellular Stress in Triple-Negative Breast Cancer Cells

Open Access 24 Apr 2026Original Research

Calcitonin Receptor is a Novel Biomarker for NF-κB-Mediated Cellular Stress in Triple-Negative Breast Cancer Cells

Hanieh Heydarlou, Reza Maleki, Peter J Wookey, Eric Smith, Wendy V Ingman

Front. Biosci. (Landmark Ed) 2026, 31(4), 50148; https://doi.org/10.31083/FBL50148

Abstract

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261

Rosuvastatin Ameliorates the Initiation and Progression of Lung Adenocarcinoma via Facilitating PLK1 Inhibition

Open Access 24 Apr 2026Original Research

Rosuvastatin Ameliorates the Initiation and Progression of Lung Adenocarcinoma via Facilitating PLK1 Inhibition

Jie Yin, Jianjie Zhu, Yinhua Gong, Wenting Wu, Xinyu Zhang, Chang Li, Yang Yang, Yili Chen, Jianjun Li, Lei Gu, Jian-an Huang, Zeyi Liu, Dan Shen, Yuanyuan Zeng

Front. Biosci. (Landmark Ed) 2026, 31(4), 49156; https://doi.org/10.31083/FBL49156

Abstract

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191

ApoA-I Dissociated From Human HDL Retains its Acceptor Properties in ABCA1-mediated Cholesterol Efflux From RAW 264.7 Macrophages in Coronary Artery Disease

Open Access 23 Apr 2026Original Research

ApoA-I Dissociated From Human HDL Retains its Acceptor Properties in ABCA1-mediated Cholesterol Efflux From RAW 264.7 Macrophages in Coronary Artery Disease

Veronika B. Baserova, Mikhail A. Popov, Alexander D. Dergunov

Front. Biosci. (Landmark Ed) 2026, 31(4), 50403; https://doi.org/10.31083/FBL50403

Abstract

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131

Platelet Factor 4: A Novel Therapeutic Inhibitor for Experimental Neovascular Age-Related Macular Degeneration

Open Access 23 Apr 2026Original Research

Platelet Factor 4: A Novel Therapeutic Inhibitor for Experimental Neovascular Age-Related Macular Degeneration

Xiubin Ke, Shuqi Liang, Tianhao Qu, Shenyu Li, Ji Lei, Han Han, Yingying Guo, Man Xing, Xiaohong Wang, Shikun He, Mengyu Liao, Dongming Zhou, Hua Yan

Front. Biosci. (Landmark Ed) 2026, 31(4), 49564; https://doi.org/10.31083/FBL49564

Abstract

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174

Annexin A5 Regulates Store-Operated Calcium Entry via Glyceraldehyde-3-Phosphate Dehydrogenase in Hepatocellular Carcinoma

Open Access 23 Apr 2026Original Research

Annexin A5 Regulates Store-Operated Calcium Entry via Glyceraldehyde-3-Phosphate Dehydrogenase in Hepatocellular Carcinoma

Weicheng Gao, Xiancheng Zhang, Shuai Ma, Feiyang Wu, Xingguo Zhong

Front. Biosci. (Landmark Ed) 2026, 31(4), 49504; https://doi.org/10.31083/FBL49504

Abstract

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133

Gender Differences in the Effects of Esomeprazole on Ethanol-Induced Acute Gastric Injury in Mice

Open Access 23 Apr 2026Original Research

Gender Differences in the Effects of Esomeprazole on Ethanol-Induced Acute Gastric Injury in Mice

Zhi-hui Yi, Yao Wu, Yang Yu, Feng Li, Tao Zeng, Yu Zeng, Linling Lv, Li-hong Wan, Ling Zhu

Front. Biosci. (Landmark Ed) 2026, 31(4), 49148; https://doi.org/10.31083/FBL49148

Abstract

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155

The Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle–Mediated Tissue Repair After Spinal Cord Injury

Open Access 23 Apr 2026Review

The Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle–Mediated Tissue Repair After Spinal Cord Injury

Masahito Nakazaki, Karen L. Lankford, Takahiro Yokoyama, Ryo Ukai, Ryosuke Hirota, Shinichi Oka, Masanori Sasaki, Jeffery D. Kocsis, Osamu Honmou

Front. Biosci. (Landmark Ed) 2026, 31(4), 47612; https://doi.org/10.31083/FBL47612

Abstract

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260

Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway

Open Access 22 Apr 2026Original Research

Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway

Qian Wu, Geying Xi, Ying Lin, Junkai Zhao, Yi Song, Huojun Jiang, Biao Zhang

Front. Biosci. (Landmark Ed) 2026, 31(4), 49062; https://doi.org/10.31083/FBL49062

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171

Enhancer of Zeste Homologue 2 Promotes Vascular Calcification Associated With Chronic Kidney Disease

Open Access 22 Apr 2026Original Research

Enhancer of Zeste Homologue 2 Promotes Vascular Calcification Associated With Chronic Kidney Disease

Pinglan Lin, Yufeng Xing, Ming Wu, Dongping Chen, Feng Yang, Di Huang, Ayijiaken Kasimumali, Yijing Zhou, Chaoyang Ye

Front. Biosci. (Landmark Ed) 2026, 31(4), 48723; https://doi.org/10.31083/FBL48723

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142

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Open Access 22 Apr 2026Original Research

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Sofya S. Pogodaeva, Olga O. Miletina, Lidia V. Mammadova, Nadezhda V. Antipova, Alexander A. Shtil, Oleg A. Kuchur

Front. Biosci. (Landmark Ed) 2026, 31(4), 48544; https://doi.org/10.31083/FBL48544

(This article belongs to the Special Issue Molecular and Cellular Mechanisms in High-Risk and Progressive Neuroblastoma)

Abstract

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274

ADAM8 Deficiency in Macrophages Alleviates Vascular Calcification in Chronic Kidney Disease

Open Access 22 Apr 2026Original Research

ADAM8 Deficiency in Macrophages Alleviates Vascular Calcification in Chronic Kidney Disease

Rong Dong, Zhenjun Ji, Mi Wang, Zaixiao Tao, Xinxin Li, Rui Zhang, Junwei Xu, Genshan Ma

Front. Biosci. (Landmark Ed) 2026, 31(4), 49495; https://doi.org/10.31083/FBL49495

Abstract

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131

Metagenomic Analysis Reveals Gut Microbiota Features in Membranous Nephropathy

Open Access 22 Apr 2026Original Research

Metagenomic Analysis Reveals Gut Microbiota Features in Membranous Nephropathy

Yanmei Li, Hanchao Gao, Zhennan Liao, Zixi Chen, Zhuoheng Song, Wenjun Xiong, Yong Dai, Weilong Li, Shaodong Luan

Front. Biosci. (Landmark Ed) 2026, 31(4), 48982; https://doi.org/10.31083/FBL48982

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103

The Gut–Lung Axis, Epigenetics and Respiratory Disease

Open Access 22 Apr 2026Review

The Gut–Lung Axis, Epigenetics and Respiratory Disease

Alex Seungyeon Byun, Philip Chi Lip Kwok, Hak-Kim Chan, Luis Vitetta

Front. Biosci. (Landmark Ed) 2026, 31(4), 48743; https://doi.org/10.31083/FBL48743

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316

Artificial Intelligence and Vitamin D Deficiency: Opportunities and Challenges for Clinical Translation in Chronic Diseases

Open Access 21 Apr 2026Editorial

Artificial Intelligence and Vitamin D Deficiency: Opportunities and Challenges for Clinical Translation in Chronic Diseases

Federica Nuccio, Emanuela Zumbo, Giuseppe Murdaca, Sebastiano Gangemi

Front. Biosci. (Landmark Ed) 2026, 31(4), 50946; https://doi.org/10.31083/FBL50946

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158

Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression

Open Access 21 Apr 2026Original Research

Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression

Ying Wang, Xue Deng, Qian-wen Zhu, Jing Zhang, Zhi-wei Qian, Fang Gao, Shu-qin Zhan, Chao Wu, Lin Wang, Shu Li, Ze-bo Hu

Front. Biosci. (Landmark Ed) 2026, 31(4), 49862; https://doi.org/10.31083/FBL49862

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116

Multi-Dimensional Data Integration Reveals the Molecular Mechanism of Metabolic Reprogramming Associated With Low Asparaginase Expression in Hepatocellular Carcinoma

Open Access 21 Apr 2026Original Research

Multi-Dimensional Data Integration Reveals the Molecular Mechanism of Metabolic Reprogramming Associated With Low Asparaginase Expression in Hepatocellular Carcinoma

Yiwu Dang, Yulong Deng, Yuxing Tang, Ruiling Su, Kesong Nong, Wei Qin, Zhendong Chen, Li Xiao, Dandan Xiong, Zhenbo Feng

Front. Biosci. (Landmark Ed) 2026, 31(4), 49215; https://doi.org/10.31083/FBL49215

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157

Potential Application of HIF-PH Inhibitors to Treat Kidney Diseases

Open Access 21 Apr 2026Review

Potential Application of HIF-PH Inhibitors to Treat Kidney Diseases

Yuichiro Izumi, Yukiko Yasuoka, Masayoshi Nanami, Katsumasa Kawahara, Hiroshi Nonoguchi

Front. Biosci. (Landmark Ed) 2026, 31(4), 47718; https://doi.org/10.31083/FBL47718

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217

CD44+ and CD133+ Extracellular Vesicles as Future Potential Targets in Gastrointestinal Tumor

Open Access 21 Apr 2026Review

CD44+ and CD133+ Extracellular Vesicles as Future Potential Targets in Gastrointestinal Tumor

Cristina Pizzulli, Beatrice Menicacci, Margherita Parrini, Edoardo Tonelli, Caterina Bartolini, Armando Curto, Giulia Petroni, Serena Pillozzi, Andrea Galli

Front. Biosci. (Landmark Ed) 2026, 31(4), 46312; https://doi.org/10.31083/FBL46312

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210

Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5′-tsRNA^Glu in Non-Small Cell Lung Cancer

Open Access 20 Apr 2026Original Research

Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5′-tsRNA^Glu in Non-Small Cell Lung Cancer

Chuanlin Shen, Haimei Cheng, Yiling Liu, Dandan Xu, Weijie Ding, Miaoyan Pu, Luyu Shi, Jiaxin Tian, Ying Zhang

Front. Biosci. (Landmark Ed) 2026, 31(4), 50109; https://doi.org/10.31083/FBL50109

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131

Ameliorative Effect of Luteolin on H₂O₂-Induced Mitophagy and Apoptosis in Cardiomyocytes Through Modulation of the AMPK/mTOR Pathway

Open Access 20 Apr 2026Original Research

Ameliorative Effect of Luteolin on H₂O₂-Induced Mitophagy and Apoptosis in Cardiomyocytes Through Modulation of the AMPK/mTOR Pathway

Zhipeng Yang, Xiaolu Liu, Daijian Liu, Kuiying Ma, Ming Zhao, Yu Wang

Front. Biosci. (Landmark Ed) 2026, 31(4), 50047; https://doi.org/10.31083/FBL50047

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150

Feature of NETosis in Chronic Granulomatous Disease and Its Impact on Renal Disorder

Open Access 20 Apr 2026Review

Feature of NETosis in Chronic Granulomatous Disease and Its Impact on Renal Disorder

Tetsuya Abe, Yukihiro Wada, Emiko Takeuchi, Masashi Satoh, Takayuki Imanishi, Makoto Otsu, Tadahiro Suenaga, Yasuo Takeuchi

Front. Biosci. (Landmark Ed) 2026, 31(4), 47594; https://doi.org/10.31083/FBL47594

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158

Ferroptosis in Breast Cancer: Molecular Insights and Therapeutic Strategies

Open Access 17 Apr 2026Review

Ferroptosis in Breast Cancer: Molecular Insights and Therapeutic Strategies

Nahid Iftikhar, Suryavathi Viswanadhapalli, Uday P. Pratap, Ratna K. Vadlamudi

Front. Biosci. (Landmark Ed) 2026, 31(4), 50950; https://doi.org/10.31083/FBL50950

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223

A Stage IA and IB Endometrial Cancer Classification Method Using Genetic Programming on MRI Images

Open Access 17 Apr 2026Original Research

A Stage IA and IB Endometrial Cancer Classification Method Using Genetic Programming on MRI Images

Chunxia Chen, Yuequan Shi, Wenting Cao, Jingde Hong, Ming Li, Yuhang Xie, Zeng Lin, Yongping Lin

Front. Biosci. (Landmark Ed) 2026, 31(4), 49257; https://doi.org/10.31083/FBL49257

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122

An Emerging Approach to IBD Treatment: Personalized Nutrition Through Gut Microbiome Optimization

Open Access 17 Apr 2026Review

An Emerging Approach to IBD Treatment: Personalized Nutrition Through Gut Microbiome Optimization

Kafayat Yusuf, Thomas M Attard, Mazin Al-Kasspooles, Shahid Umar

Front. Biosci. (Landmark Ed) 2026, 31(4), 47779; https://doi.org/10.31083/FBL47779

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264

Keap1-Nrf2 Signaling Pathway-Mediated Antioxidant Defense in Neurodegenerative Diseases: Mechanisms and Traditional Chinese Medicine Therapeutic Strategies

Open Access 17 Apr 2026Review

Keap1-Nrf2 Signaling Pathway-Mediated Antioxidant Defense in Neurodegenerative Diseases: Mechanisms and Traditional Chinese Medicine Therapeutic Strategies

Wentao Chen, Jiying Wang, Qing Li, Linao Zhang, Xue Wu, Shifang Luo, Yuhuan Xie, Peixin Guo

Front. Biosci. (Landmark Ed) 2026, 31(4), 45233; https://doi.org/10.31083/FBL45233

(This article belongs to the Special Issue Exploring Pathomechanisms, Novel Targets, and New Interventions of Neurological and Neuropsychiatric Disorders - Volume 2)

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209

NDRG2 Drives DRP1 Phosphorylation to Promote the Progression of Pulmonary Hypertension

Open Access 14 Apr 2026Original Research

NDRG2 Drives DRP1 Phosphorylation to Promote the Progression of Pulmonary Hypertension

Jiayong Luo, Jinyu Chang, Yi Liu, Yusang Shao, Yanyan Zhang, Yingru Zheng, Enfang Xiao, Yanqing Xie, Shuangshuang Tu, Haoxuan Lu, Wenming He

Front. Biosci. (Landmark Ed) 2026, 31(4), 48054; https://doi.org/10.31083/FBL48054

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194

Computational Pathology as a Mechanistic Discipline: From Morphology to Molecular Data

Open Access 14 Apr 2026Opinion

Computational Pathology as a Mechanistic Discipline: From Morphology to Molecular Data

Nicola Fusco, Konstantinos Venetis

Front. Biosci. (Landmark Ed) 2026, 31(4), 47914; https://doi.org/10.31083/FBL47914

(This article belongs to the Special Issue Machine Learning in Molecular Biology)

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431

Hypoxic Regulation of Notch1 Promotes Mitochondrial Fission and Scleral Remodeling in Myopia

Open Access 9 Apr 2026Original Research

Hypoxic Regulation of Notch1 Promotes Mitochondrial Fission and Scleral Remodeling in Myopia

Lingling Ba, Jie Wang, Shuaixin Lu, Xinmiao Zhou, Min Zhou, Peiyao Huang, Simo Pan, Xiaohua Zhang, Kai Wen, Jing Sun

Front. Biosci. (Landmark Ed) 2026, 31(4), 49381; https://doi.org/10.31083/FBL49381

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282

From Normal Mucosa to Colorectal Cancer in Lynch Syndrome: Single-Cell Dissection of Cellular Heterogeneity and Communication Networks

Open Access 9 Apr 2026Original Research

From Normal Mucosa to Colorectal Cancer in Lynch Syndrome: Single-Cell Dissection of Cellular Heterogeneity and Communication Networks

Shangxiang Chen, Jishen Feng, Zhengkai Fang, Yuhao Jiang, Jinzhong Duanmu, Xin Yu, Junfu Wang, Qunguang Jiang

Front. Biosci. (Landmark Ed) 2026, 31(4), 47730; https://doi.org/10.31083/FBL47730

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264

Quercetin Enhances the Antitumor Effect of Lenvatinib on Hepatocellular Carcinoma Cells

Open Access 31 Mar 2026Original Research

Quercetin Enhances the Antitumor Effect of Lenvatinib on Hepatocellular Carcinoma Cells

Jian Li, Qinghua Yin, Kai Liu, Xu Chen, Yang Zhou

Front. Biosci. (Landmark Ed) 2026, 31(4), 47715; https://doi.org/10.31083/FBL47715

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288

Discovering the Hidden Power of NGLY1: Orchestrating Immune Cell Functions and Autoimmune Diseases

Open Access 31 Mar 2026Review

Discovering the Hidden Power of NGLY1: Orchestrating Immune Cell Functions and Autoimmune Diseases

Christina B. Brunner, Melissa C. Schubbert, Maximilian M. Siewert, Michèle Ohnemüller, Frederic Kuwert, Ulla I. M. Gerling-Driessen, Katharina Pracht

Front. Biosci. (Landmark Ed) 2026, 31(4), 46961; https://doi.org/10.31083/FBL46961

(This article belongs to the Special Issue Cellular and Molecular Study in Immunopharmacology)

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481

Roles of AKR1C1 in Non-small Cell Lung Cancer

Open Access 26 Mar 2026Review

Roles of AKR1C1 in Non-small Cell Lung Cancer

Xinran Zhang, Qi Zhang, Yuting Chang, Gaohua Han

Front. Biosci. (Landmark Ed) 2026, 31(4), 45736; https://doi.org/10.31083/FBL45736

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249

Establishment of a Novel IDH1 wild type Glioblastoma Cell Line, SHG142, and Its Organoids

Open Access 26 Mar 2026Original Research

Establishment of a Novel IDH1 wild type Glioblastoma Cell Line, SHG142, and Its Organoids

Heyang Gao, Hao Wang, Lin Yao, Guozheng Zhao, Liyan Tang, Xiao Zhang, Jialiang Qian, Xiyang Weng, Youxin Zhou

Front. Biosci. (Landmark Ed) 2026, 31(4), 49045; https://doi.org/10.31083/FBL49045

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358

Volume 31, Issue 4 (2026)

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Article

Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina

Open Access 27 Apr 2026Original Research

Effect of Endogenous FGF21 Deficiency on the Inflammatory Microenvironment of the Retina

Ting-ting Zhao, Ming-kai Chang, Bai-yun Shen, Hao-ran Guo, Yu-tong Han, Wen-fei Wang

Front. Biosci. (Landmark Ed) 2026, 31(4), 47702; https://doi.org/10.31083/FBL47702

Abstract

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195

Context-Dependent Modulation of Macrophage Plasticity by Cordycepin Drives Tumor Regression in Melanoma

Open Access 27 Apr 2026Original Research

Context-Dependent Modulation of Macrophage Plasticity by Cordycepin Drives Tumor Regression in Melanoma

Jihae Lim, Donglan Piao, Jio Kang, Suh Jin Yoon, Hyun Ji Lee, Isoo Youn, Eun Kyoung Seo, Eun Sook Hwang

Front. Biosci. (Landmark Ed) 2026, 31(4), 52067; https://doi.org/10.31083/FBL52067

Abstract

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507

Retraction: Li et al. MEG3 Targets miR-184 and Wnt/β-catenin and Modulates Properties of Osteosarcoma. Frontiers in Bioscience (Landmark Edition). 2020; 25: 1901–1912

Open Access 27 Apr 2026Retraction

Retraction: Li et al. MEG3 Targets miR-184 and Wnt/β-catenin and Modulates Properties of Osteosarcoma. Frontiers in Bioscience (Landmark Edition). 2020; 25: 1901–1912

Frontiers in Bioscience-Landmark Editorial Office

Front. Biosci. (Landmark Ed) 2026, 31(4), 53323; https://doi.org/10.31083/FBL53323

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237

Calcitonin Receptor is a Novel Biomarker for NF-κB-Mediated Cellular Stress in Triple-Negative Breast Cancer Cells

Open Access 24 Apr 2026Original Research

Calcitonin Receptor is a Novel Biomarker for NF-κB-Mediated Cellular Stress in Triple-Negative Breast Cancer Cells

Hanieh Heydarlou, Reza Maleki, Peter J Wookey, Eric Smith, Wendy V Ingman

Front. Biosci. (Landmark Ed) 2026, 31(4), 50148; https://doi.org/10.31083/FBL50148

Abstract

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261

Rosuvastatin Ameliorates the Initiation and Progression of Lung Adenocarcinoma via Facilitating PLK1 Inhibition

Open Access 24 Apr 2026Original Research

Rosuvastatin Ameliorates the Initiation and Progression of Lung Adenocarcinoma via Facilitating PLK1 Inhibition

Jie Yin, Jianjie Zhu, Yinhua Gong, Wenting Wu, Xinyu Zhang, Chang Li, Yang Yang, Yili Chen, Jianjun Li, Lei Gu, Jian-an Huang, Zeyi Liu, Dan Shen, Yuanyuan Zeng

Front. Biosci. (Landmark Ed) 2026, 31(4), 49156; https://doi.org/10.31083/FBL49156

Abstract

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191

ApoA-I Dissociated From Human HDL Retains its Acceptor Properties in ABCA1-mediated Cholesterol Efflux From RAW 264.7 Macrophages in Coronary Artery Disease

Open Access 23 Apr 2026Original Research

ApoA-I Dissociated From Human HDL Retains its Acceptor Properties in ABCA1-mediated Cholesterol Efflux From RAW 264.7 Macrophages in Coronary Artery Disease

Veronika B. Baserova, Mikhail A. Popov, Alexander D. Dergunov

Front. Biosci. (Landmark Ed) 2026, 31(4), 50403; https://doi.org/10.31083/FBL50403

Abstract

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131

Platelet Factor 4: A Novel Therapeutic Inhibitor for Experimental Neovascular Age-Related Macular Degeneration

Open Access 23 Apr 2026Original Research

Platelet Factor 4: A Novel Therapeutic Inhibitor for Experimental Neovascular Age-Related Macular Degeneration

Xiubin Ke, Shuqi Liang, Tianhao Qu, Shenyu Li, Ji Lei, Han Han, Yingying Guo, Man Xing, Xiaohong Wang, Shikun He, Mengyu Liao, Dongming Zhou, Hua Yan

Front. Biosci. (Landmark Ed) 2026, 31(4), 49564; https://doi.org/10.31083/FBL49564

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174

Annexin A5 Regulates Store-Operated Calcium Entry via Glyceraldehyde-3-Phosphate Dehydrogenase in Hepatocellular Carcinoma

Open Access 23 Apr 2026Original Research

Annexin A5 Regulates Store-Operated Calcium Entry via Glyceraldehyde-3-Phosphate Dehydrogenase in Hepatocellular Carcinoma

Weicheng Gao, Xiancheng Zhang, Shuai Ma, Feiyang Wu, Xingguo Zhong

Front. Biosci. (Landmark Ed) 2026, 31(4), 49504; https://doi.org/10.31083/FBL49504

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133

Gender Differences in the Effects of Esomeprazole on Ethanol-Induced Acute Gastric Injury in Mice

Open Access 23 Apr 2026Original Research

Gender Differences in the Effects of Esomeprazole on Ethanol-Induced Acute Gastric Injury in Mice

Zhi-hui Yi, Yao Wu, Yang Yu, Feng Li, Tao Zeng, Yu Zeng, Linling Lv, Li-hong Wan, Ling Zhu

Front. Biosci. (Landmark Ed) 2026, 31(4), 49148; https://doi.org/10.31083/FBL49148

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155

The Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle–Mediated Tissue Repair After Spinal Cord Injury

Open Access 23 Apr 2026Review

The Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle–Mediated Tissue Repair After Spinal Cord Injury

Masahito Nakazaki, Karen L. Lankford, Takahiro Yokoyama, Ryo Ukai, Ryosuke Hirota, Shinichi Oka, Masanori Sasaki, Jeffery D. Kocsis, Osamu Honmou

Front. Biosci. (Landmark Ed) 2026, 31(4), 47612; https://doi.org/10.31083/FBL47612

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260

Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway

Open Access 22 Apr 2026Original Research

Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway

Qian Wu, Geying Xi, Ying Lin, Junkai Zhao, Yi Song, Huojun Jiang, Biao Zhang

Front. Biosci. (Landmark Ed) 2026, 31(4), 49062; https://doi.org/10.31083/FBL49062

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171

Enhancer of Zeste Homologue 2 Promotes Vascular Calcification Associated With Chronic Kidney Disease

Open Access 22 Apr 2026Original Research

Enhancer of Zeste Homologue 2 Promotes Vascular Calcification Associated With Chronic Kidney Disease

Pinglan Lin, Yufeng Xing, Ming Wu, Dongping Chen, Feng Yang, Di Huang, Ayijiaken Kasimumali, Yijing Zhou, Chaoyang Ye

Front. Biosci. (Landmark Ed) 2026, 31(4), 48723; https://doi.org/10.31083/FBL48723

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142

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Open Access 22 Apr 2026Original Research

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Sofya S. Pogodaeva, Olga O. Miletina, Lidia V. Mammadova, Nadezhda V. Antipova, Alexander A. Shtil, Oleg A. Kuchur

Front. Biosci. (Landmark Ed) 2026, 31(4), 48544; https://doi.org/10.31083/FBL48544

(This article belongs to the Special Issue Molecular and Cellular Mechanisms in High-Risk and Progressive Neuroblastoma)

Abstract

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274

ADAM8 Deficiency in Macrophages Alleviates Vascular Calcification in Chronic Kidney Disease

Open Access 22 Apr 2026Original Research

ADAM8 Deficiency in Macrophages Alleviates Vascular Calcification in Chronic Kidney Disease

Rong Dong, Zhenjun Ji, Mi Wang, Zaixiao Tao, Xinxin Li, Rui Zhang, Junwei Xu, Genshan Ma

Front. Biosci. (Landmark Ed) 2026, 31(4), 49495; https://doi.org/10.31083/FBL49495

Abstract

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131

Metagenomic Analysis Reveals Gut Microbiota Features in Membranous Nephropathy

Open Access 22 Apr 2026Original Research

Metagenomic Analysis Reveals Gut Microbiota Features in Membranous Nephropathy

Yanmei Li, Hanchao Gao, Zhennan Liao, Zixi Chen, Zhuoheng Song, Wenjun Xiong, Yong Dai, Weilong Li, Shaodong Luan

Front. Biosci. (Landmark Ed) 2026, 31(4), 48982; https://doi.org/10.31083/FBL48982

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103

The Gut–Lung Axis, Epigenetics and Respiratory Disease

Open Access 22 Apr 2026Review

The Gut–Lung Axis, Epigenetics and Respiratory Disease

Alex Seungyeon Byun, Philip Chi Lip Kwok, Hak-Kim Chan, Luis Vitetta

Front. Biosci. (Landmark Ed) 2026, 31(4), 48743; https://doi.org/10.31083/FBL48743

Abstract

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316

Artificial Intelligence and Vitamin D Deficiency: Opportunities and Challenges for Clinical Translation in Chronic Diseases

Open Access 21 Apr 2026Editorial

Artificial Intelligence and Vitamin D Deficiency: Opportunities and Challenges for Clinical Translation in Chronic Diseases

Federica Nuccio, Emanuela Zumbo, Giuseppe Murdaca, Sebastiano Gangemi

Front. Biosci. (Landmark Ed) 2026, 31(4), 50946; https://doi.org/10.31083/FBL50946

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158

Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression

Open Access 21 Apr 2026Original Research

Emodin Alleviates Lipid Accumulation and Renal Tubular Injury in Rats With DN via Inhibiting HIF-1α Expression

Ying Wang, Xue Deng, Qian-wen Zhu, Jing Zhang, Zhi-wei Qian, Fang Gao, Shu-qin Zhan, Chao Wu, Lin Wang, Shu Li, Ze-bo Hu

Front. Biosci. (Landmark Ed) 2026, 31(4), 49862; https://doi.org/10.31083/FBL49862

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116

Multi-Dimensional Data Integration Reveals the Molecular Mechanism of Metabolic Reprogramming Associated With Low Asparaginase Expression in Hepatocellular Carcinoma

Open Access 21 Apr 2026Original Research

Multi-Dimensional Data Integration Reveals the Molecular Mechanism of Metabolic Reprogramming Associated With Low Asparaginase Expression in Hepatocellular Carcinoma

Yiwu Dang, Yulong Deng, Yuxing Tang, Ruiling Su, Kesong Nong, Wei Qin, Zhendong Chen, Li Xiao, Dandan Xiong, Zhenbo Feng

Front. Biosci. (Landmark Ed) 2026, 31(4), 49215; https://doi.org/10.31083/FBL49215

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157

Potential Application of HIF-PH Inhibitors to Treat Kidney Diseases

Open Access 21 Apr 2026Review

Potential Application of HIF-PH Inhibitors to Treat Kidney Diseases

Yuichiro Izumi, Yukiko Yasuoka, Masayoshi Nanami, Katsumasa Kawahara, Hiroshi Nonoguchi

Front. Biosci. (Landmark Ed) 2026, 31(4), 47718; https://doi.org/10.31083/FBL47718

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217

CD44+ and CD133+ Extracellular Vesicles as Future Potential Targets in Gastrointestinal Tumor

Open Access 21 Apr 2026Review

CD44+ and CD133+ Extracellular Vesicles as Future Potential Targets in Gastrointestinal Tumor

Cristina Pizzulli, Beatrice Menicacci, Margherita Parrini, Edoardo Tonelli, Caterina Bartolini, Armando Curto, Giulia Petroni, Serena Pillozzi, Andrea Galli

Front. Biosci. (Landmark Ed) 2026, 31(4), 46312; https://doi.org/10.31083/FBL46312

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210

Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5′-tsRNA^Glu in Non-Small Cell Lung Cancer

Open Access 20 Apr 2026Original Research

Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5′-tsRNA^Glu in Non-Small Cell Lung Cancer

Chuanlin Shen, Haimei Cheng, Yiling Liu, Dandan Xu, Weijie Ding, Miaoyan Pu, Luyu Shi, Jiaxin Tian, Ying Zhang

Front. Biosci. (Landmark Ed) 2026, 31(4), 50109; https://doi.org/10.31083/FBL50109

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131

Ameliorative Effect of Luteolin on H₂O₂-Induced Mitophagy and Apoptosis in Cardiomyocytes Through Modulation of the AMPK/mTOR Pathway

Open Access 20 Apr 2026Original Research

Ameliorative Effect of Luteolin on H₂O₂-Induced Mitophagy and Apoptosis in Cardiomyocytes Through Modulation of the AMPK/mTOR Pathway

Zhipeng Yang, Xiaolu Liu, Daijian Liu, Kuiying Ma, Ming Zhao, Yu Wang

Front. Biosci. (Landmark Ed) 2026, 31(4), 50047; https://doi.org/10.31083/FBL50047

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150

Feature of NETosis in Chronic Granulomatous Disease and Its Impact on Renal Disorder

Open Access 20 Apr 2026Review

Feature of NETosis in Chronic Granulomatous Disease and Its Impact on Renal Disorder

Tetsuya Abe, Yukihiro Wada, Emiko Takeuchi, Masashi Satoh, Takayuki Imanishi, Makoto Otsu, Tadahiro Suenaga, Yasuo Takeuchi

Front. Biosci. (Landmark Ed) 2026, 31(4), 47594; https://doi.org/10.31083/FBL47594

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158

Ferroptosis in Breast Cancer: Molecular Insights and Therapeutic Strategies

Open Access 17 Apr 2026Review

Ferroptosis in Breast Cancer: Molecular Insights and Therapeutic Strategies

Nahid Iftikhar, Suryavathi Viswanadhapalli, Uday P. Pratap, Ratna K. Vadlamudi

Front. Biosci. (Landmark Ed) 2026, 31(4), 50950; https://doi.org/10.31083/FBL50950

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223

A Stage IA and IB Endometrial Cancer Classification Method Using Genetic Programming on MRI Images

Open Access 17 Apr 2026Original Research

A Stage IA and IB Endometrial Cancer Classification Method Using Genetic Programming on MRI Images

Chunxia Chen, Yuequan Shi, Wenting Cao, Jingde Hong, Ming Li, Yuhang Xie, Zeng Lin, Yongping Lin

Front. Biosci. (Landmark Ed) 2026, 31(4), 49257; https://doi.org/10.31083/FBL49257

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122

An Emerging Approach to IBD Treatment: Personalized Nutrition Through Gut Microbiome Optimization

Open Access 17 Apr 2026Review

An Emerging Approach to IBD Treatment: Personalized Nutrition Through Gut Microbiome Optimization

Kafayat Yusuf, Thomas M Attard, Mazin Al-Kasspooles, Shahid Umar

Front. Biosci. (Landmark Ed) 2026, 31(4), 47779; https://doi.org/10.31083/FBL47779

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264

Keap1-Nrf2 Signaling Pathway-Mediated Antioxidant Defense in Neurodegenerative Diseases: Mechanisms and Traditional Chinese Medicine Therapeutic Strategies

Open Access 17 Apr 2026Review

Keap1-Nrf2 Signaling Pathway-Mediated Antioxidant Defense in Neurodegenerative Diseases: Mechanisms and Traditional Chinese Medicine Therapeutic Strategies

Wentao Chen, Jiying Wang, Qing Li, Linao Zhang, Xue Wu, Shifang Luo, Yuhuan Xie, Peixin Guo

Front. Biosci. (Landmark Ed) 2026, 31(4), 45233; https://doi.org/10.31083/FBL45233

(This article belongs to the Special Issue Exploring Pathomechanisms, Novel Targets, and New Interventions of Neurological and Neuropsychiatric Disorders - Volume 2)

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209

NDRG2 Drives DRP1 Phosphorylation to Promote the Progression of Pulmonary Hypertension

Open Access 14 Apr 2026Original Research

NDRG2 Drives DRP1 Phosphorylation to Promote the Progression of Pulmonary Hypertension

Jiayong Luo, Jinyu Chang, Yi Liu, Yusang Shao, Yanyan Zhang, Yingru Zheng, Enfang Xiao, Yanqing Xie, Shuangshuang Tu, Haoxuan Lu, Wenming He

Front. Biosci. (Landmark Ed) 2026, 31(4), 48054; https://doi.org/10.31083/FBL48054

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194

Computational Pathology as a Mechanistic Discipline: From Morphology to Molecular Data

Open Access 14 Apr 2026Opinion

Computational Pathology as a Mechanistic Discipline: From Morphology to Molecular Data

Nicola Fusco, Konstantinos Venetis

Front. Biosci. (Landmark Ed) 2026, 31(4), 47914; https://doi.org/10.31083/FBL47914

(This article belongs to the Special Issue Machine Learning in Molecular Biology)

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431

Hypoxic Regulation of Notch1 Promotes Mitochondrial Fission and Scleral Remodeling in Myopia

Open Access 9 Apr 2026Original Research

Hypoxic Regulation of Notch1 Promotes Mitochondrial Fission and Scleral Remodeling in Myopia

Lingling Ba, Jie Wang, Shuaixin Lu, Xinmiao Zhou, Min Zhou, Peiyao Huang, Simo Pan, Xiaohua Zhang, Kai Wen, Jing Sun

Front. Biosci. (Landmark Ed) 2026, 31(4), 49381; https://doi.org/10.31083/FBL49381

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282

From Normal Mucosa to Colorectal Cancer in Lynch Syndrome: Single-Cell Dissection of Cellular Heterogeneity and Communication Networks

Open Access 9 Apr 2026Original Research

From Normal Mucosa to Colorectal Cancer in Lynch Syndrome: Single-Cell Dissection of Cellular Heterogeneity and Communication Networks

Shangxiang Chen, Jishen Feng, Zhengkai Fang, Yuhao Jiang, Jinzhong Duanmu, Xin Yu, Junfu Wang, Qunguang Jiang

Front. Biosci. (Landmark Ed) 2026, 31(4), 47730; https://doi.org/10.31083/FBL47730

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264

Quercetin Enhances the Antitumor Effect of Lenvatinib on Hepatocellular Carcinoma Cells

Open Access 31 Mar 2026Original Research

Quercetin Enhances the Antitumor Effect of Lenvatinib on Hepatocellular Carcinoma Cells

Jian Li, Qinghua Yin, Kai Liu, Xu Chen, Yang Zhou

Front. Biosci. (Landmark Ed) 2026, 31(4), 47715; https://doi.org/10.31083/FBL47715

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288

Discovering the Hidden Power of NGLY1: Orchestrating Immune Cell Functions and Autoimmune Diseases

Open Access 31 Mar 2026Review

Discovering the Hidden Power of NGLY1: Orchestrating Immune Cell Functions and Autoimmune Diseases

Christina B. Brunner, Melissa C. Schubbert, Maximilian M. Siewert, Michèle Ohnemüller, Frederic Kuwert, Ulla I. M. Gerling-Driessen, Katharina Pracht

Front. Biosci. (Landmark Ed) 2026, 31(4), 46961; https://doi.org/10.31083/FBL46961

(This article belongs to the Special Issue Cellular and Molecular Study in Immunopharmacology)

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481

Roles of AKR1C1 in Non-small Cell Lung Cancer

Open Access 26 Mar 2026Review

Roles of AKR1C1 in Non-small Cell Lung Cancer

Xinran Zhang, Qi Zhang, Yuting Chang, Gaohua Han

Front. Biosci. (Landmark Ed) 2026, 31(4), 45736; https://doi.org/10.31083/FBL45736

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249

Establishment of a Novel IDH1 wild type Glioblastoma Cell Line, SHG142, and Its Organoids

Open Access 26 Mar 2026Original Research

Establishment of a Novel IDH1 wild type Glioblastoma Cell Line, SHG142, and Its Organoids

Heyang Gao, Hao Wang, Lin Yao, Guozheng Zhao, Liyan Tang, Xiao Zhang, Jialiang Qian, Xiyang Weng, Youxin Zhou

Front. Biosci. (Landmark Ed) 2026, 31(4), 49045; https://doi.org/10.31083/FBL49045

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358