The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival

Michal Oshry, Roi Isaac, Sigalit Boura-Halfon, Estefania Casana, Sanford Sampson, Sima Lev, Fatima Bosch, Yehiel Zick, Yaron Vinik

Front. Biosci. (Landmark Ed) 2026, 31(3), 44406; https://doi.org/10.31083/FBL44406

Precision Diagnostics in Primary Sjögren’s Syndrome: Advances in Biomarkers, Epigenetic Markers, Immune Pathways, and Clinical Translation

Thao Thi Do, Vy Thuy Nguyen, Kim Tran Thien Duong, Huy Gia Truong, Duong Nguyen Thuy Le, Quan Minh Mai Le, Thu Ngoc Trinh, Tin Hoang Nguyen

Front. Biosci. (Landmark Ed) 2026, 31(3), 44757; https://doi.org/10.31083/FBL44757

The Dual Role of DNA Hypermethylation and Hypomethylation in Colorectal and Gastric Tumorigenesis: Mechanisms and Non-Invasive Biomarker

Long Bai, Xuehan Yan, Zheng Wang, Zizhen Zhang

Front. Biosci. (Landmark Ed) 2026, 31(3), 46159; https://doi.org/10.31083/FBL46159

Glucose Exposure After Fertilization Shifts Preimplantation Mouse Embryos Towards a More Autophagy-Dependent and Less Mitochondria-Dependent Development

Kaname Sato, Ryoma Fujita, Yuu Akaike, Saya Kanie, Sotaro Yoshino, Shinji Nishikawa, Yoshiki Nakamura, Kodai Miyagi, Satoshi Kishigami

Front. Biosci. (Landmark Ed) 2026, 31(3), 49320; https://doi.org/10.31083/FBL49320

Synergistic Anticancer Activity of Dual-Molecule-Loaded Polymeric Films Based on Hyaluronic Acid Against Melanoma

Polina G. Serbun, Svetlana N. Morozkina, Roman O. Shaikenov, Ksenia S. Zavkibekova, Elena A. Vinogradova, Anna V. Motorzhina, Kateryna V. Levada, Hao Wu, Jingran Zhang, Zuobin Wang, Petr P. Snetkov

Front. Biosci. (Landmark Ed) 2026, 31(3), 48405; https://doi.org/10.31083/FBL48405

(This article belongs to the Special Issue Natural Antioxidants: Therapeutic Advances in Inflammatory Disorders and Cancer)

High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison

Chengsi Qian, Zuowei Pei, Zhou Yang, Min Sun, Ya Zhang, Hongyang Liu, Yan Sun

Front. Biosci. (Landmark Ed) 2026, 31(3), 47751; https://doi.org/10.31083/FBL47751

Cannabigerol Reduces Lipid Peroxidation Influencing Oxidative Stress and Inflammation Signaling Pathways in Melanocytes Exposed to UVA Radiation

Iwona Jarocka-Karpowicz, Agnieszka Gęgotek, Neven Žarković, Audrius Maruška, Elżbieta Skrzydlewska

Front. Biosci. (Landmark Ed) 2026, 31(3), 47793; https://doi.org/10.31083/FBL47793

OTUB2 Mutation Promotes Thyroid Collision Tumor’s Insights From the Whole-exome Sequence

Ying Xu, Qian Li, Mengyu Li

Front. Biosci. (Landmark Ed) 2026, 31(3), 49970; https://doi.org/10.31083/FBL49970

Therapeutic Modulation of the Gut Microbiome in Coronary Artery Disease: Current Evidence and Future Directions

Pengpeng Wang, Liqiong Ding, Zekun Lang, Yue Zhang, Ying Yu

Front. Biosci. (Landmark Ed) 2026, 31(3), 45081; https://doi.org/10.31083/FBL45081

NAD⁺ Homeostasis and Mitochondrial Modifiability: Resilience in Alzheimer’s Disease

George B. Stefano

Front. Biosci. (Landmark Ed) 2026, 31(3), 49714; https://doi.org/10.31083/FBL49714

Bioinformatics-Based Identification and Clinical Validation of CHST1 as a Potential Prognostic Gene Associated With EMT in Gastric Cancer

Xufu Qin, Yu Han, Zetao Wang, Xiaohui Zhou, Lijun Shi

Front. Biosci. (Landmark Ed) 2026, 31(3), 47627; https://doi.org/10.31083/FBL47627

COL11A1 Inhibits Ferroptosis in Pancreatic Cancer by Regulating AKT/Beclin 1 Dependent Autophagy

Hui Wang, Shuang Zhi, Zibo Yang, Na Gu, Linlin Dai, Jun Cai, Juan Wang, Dongdong Li

Front. Biosci. (Landmark Ed) 2026, 31(3), 49200; https://doi.org/10.31083/FBL49200

(This article belongs to the Special Issue Ferroptosis and Immunity: Emerging Frontiers in Immunogenic Cell Death and Cancer Therapy)

Major Depression-Associated NEGR1 Gene is Modulated in Stress-Susceptible Male Mice

Jessica Mingardi, Marco Salluzzo, Roberto Rimondini, Laura Musazzi, Lucia Carboni

Front. Biosci. (Landmark Ed) 2026, 31(3), 49360; https://doi.org/10.31083/FBL49360

CENPA Promotes Endometrial Cancer Progression by Stabilizing YY1 and Enhancing Glycolytic Metabolism

Liqun Wang, Huaying Wu, Xiaohan Tang, Xiushuang Zheng, Lin Zhou, Meisong Lu

Front. Biosci. (Landmark Ed) 2026, 31(3), 49033; https://doi.org/10.31083/FBL49033

PTBP1 Facilitates Acute Myeloid Leukemia Cell Migration, Invasion, and Expression of EMT Markers by Regulating WNK1

Xue Qiao, Xiaolei Zhang, Tian Tian, Yang Li, Shukai Qiao, Feng He, Lina Xing

Front. Biosci. (Landmark Ed) 2026, 31(3), 47982; https://doi.org/10.31083/FBL47982

The Action Mechanism of Dendrobium spp. in Treating Dry Eye Disease Based on Network Pharmacology and In Vitro Experiments

Shanshan Zhu, Jiayi Li, Yao Lu, Cheng Sun, Yushan Zou, Yujie Wang, Siqi Wu, Jin Yao, Wen Bai

Front. Biosci. (Landmark Ed) 2026, 31(3), 47218; https://doi.org/10.31083/FBL47218

Mouse Models of Diabetic Complications: Dissecting Molecular Mechanisms of Disease Progression

Aejin Lee

Front. Biosci. (Landmark Ed) 2026, 31(3), 45430; https://doi.org/10.31083/FBL45430

Selenium Protects Against Cadmium-Induced Hepatotoxicity via Regulation of Lipid Metabolism and Inflammatory Pathways

Zilong Wu, Xinyi Chen, Xiaoying Pan, Kai Luo, Zixiong Zhang, Changyu Zhou, Haibo Wang, Chuying Huang

Front. Biosci. (Landmark Ed) 2026, 31(3), 50288; https://doi.org/10.31083/FBL50288

TNFRSF21 Orchestrates Epithelial Keratinization and Tight Junction Integrity in Periodontitis-Associated Oral Mucosal Repair

Wenhao Zhang, Yulong Zhang, Zhongxuan Sun, Siyu Jin, Bin Liu, Fei Xu, Yutong Lu, Ying Yang, Mingyue Wu, Wansu Sun, Hengguo Zhang

Front. Biosci. (Landmark Ed) 2026, 31(3), 48371; https://doi.org/10.31083/FBL48371

(This article belongs to the Special Issue Roles of Inflammasomes and Their Molecular Mechanisms)

Transcription Factor Acetylation and Cell Fate Control: A Molecular Switch in Hematopoiesis and Myogenesis

Pegah Ghavidel, Yassine Abdelmalki, Marie-Claude Sincennes

Front. Biosci. (Landmark Ed) 2026, 31(3), 46704; https://doi.org/10.31083/FBL46704

ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL–Induced Foam Cells

Shaoyu Wu, Feihuang Han, Zheng Qiao, Sheng Yuan, Xiaohui Bian, Bin Zhang, Kefei Dou, Dunliang Ma

Front. Biosci. (Landmark Ed) 2026, 31(3), 47686; https://doi.org/10.31083/FBL47686

Mitochondrial Metabolism in Breast Cancer

Qian Hu, Zhihao Luo, Weixi Yuan, Qingshuang Zou, Li Wang, Yan He, Yao Shen, Xiaosha Wen, Shang Chen, Quan Liu, Dixian Luo, Zifen Guo

Front. Biosci. (Landmark Ed) 2026, 31(3), 45543; https://doi.org/10.31083/FBL45543

(This article belongs to the Special Issue Mitochondria Targeting Strategies for Treatment of Human Diseases)

Potential Application of CAR-NK Cells as an Ex Vivo Therapy for T-cell-related Diseases

Daekee Kwon, Kyung-Sun Kang

Front. Biosci. (Landmark Ed) 2026, 31(3), 48704; https://doi.org/10.31083/FBL48704

Low-LET X-ray Radiation Enhances the Cellular Connectivity Through Tunneling Nanotubes in Glioblastoma Cells

Nicole Matejka, Jessica Neubauer, Sarah Rudigkeit, Judith Reindl

Front. Biosci. (Landmark Ed) 2026, 31(3), 47233; https://doi.org/10.31083/FBL47233

Aptamer- and Ribozyme-Engineered sgRNAs for Conditional Control of CRISPR/Cas9 Function

Wei Wang, Liting Li, Xiaohui Li, Qiulong Zhang, Yan Liu

Front. Biosci. (Landmark Ed) 2026, 31(3), 47300; https://doi.org/10.31083/FBL47300

Comprehensive Analysis of N7-Methylguanosine-Modified Long Non-Coding RNAs Identifies DPY19L1P1 as a Key Oncogenic Effector in Oral Squamous Cell Carcinoma

Kexin Liang, Hui Gong, Simiao Bian, Huiyang Xu, Rui Zang, Jiayi Hao, Yajie Wang, Yue Zhang, Yingying Jiang

Front. Biosci. (Landmark Ed) 2026, 31(3), 48929; https://doi.org/10.31083/FBL48929

Acupuncture Attenuates Allergic Airway Inflammation via CC10-Mediated Modulation of Lung Dendritic Cells

Jie Long, Mi Cheng, Quan-Long Wu, Ya-Ya Zhang, Yu Wang, Yan-Jiao Chen, Lei-Miao Yin, Yong-Qing Yang, Yu-Dong Xu

Front. Biosci. (Landmark Ed) 2026, 31(3), 48140; https://doi.org/10.31083/FBL48140

The Role of Mast Cells in the Development and Progression of Atherosclerosis

Alexander Blagov, Alikhan Asoyan, Olga Maltseva, Alexander Orekhov

Front. Biosci. (Landmark Ed) 2026, 31(3), 45367; https://doi.org/10.31083/FBL45367

The Mechanism of PANoptosis in Alzheimer’s Disease: Exploring the Multiple Network Regulation of Cell Death

Huan Wei, Binchuan Wang, Jie Yang, Lishang Liao

Front. Biosci. (Landmark Ed) 2026, 31(3), 45499; https://doi.org/10.31083/FBL45499

DHA Ameliorates Alzheimer’s Disease by Attenuating Microglial Pyroptosis via Regulation of the HOXA9-NLRP3 Pathway

Jia-Li Xie, Xiao-Hui Hu, Chun-Ling Wu, Qi Jin, Jian-Ping Pan

Front. Biosci. (Landmark Ed) 2026, 31(3), 46572; https://doi.org/10.31083/FBL46572