Dear Colleagues,

Ferroptosis, a regulated form of iron-dependent cell death driven by lipid peroxidation, has emerged as a critical modulator of immune responses in both physiological and pathological contexts. Its non-apoptotic nature and unique biochemical features distinguish it from other forms of regulated cell death and offer novel therapeutic avenues, particularly in oncology and inflammatory diseases. Recent discoveries have highlighted the intricate crosstalk between ferroptosis and the immune system, revealing its dual role as both a trigger and consequence of immune activation. Notably, ferroptosis can promote immunogenic cell death, releasing danger-associated molecular patterns and lipid peroxidation byproducts that reshape the tumor microenvironment and influence immune surveillance.

This special issue aims to explore the mechanistic underpinnings and translational implications of ferroptosis in the regulation of innate and adaptive immunity, with a special focus on its role in immunogenic cell death. We welcome original research and review articles addressing ferroptosis-induced immune responses, the immunomodulatory potential of ferroptosis inducers, interactions with immune checkpoints and T-cell activation, and the development of combination strategies integrating ferroptosis with immunotherapy. By bridging ferroptosis and immunity, this collection seeks to advance our understanding of immune–tumor dynamics and uncover novel therapeutic targets to enhance anticancer efficacy and overcome immune resistance.

Flavia Biamonte
Guest Editor