Dear Colleagues,

Inflammasomes are cytosolic protein complexes that act as molecular platforms initiating inflammatory responses to diverse pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). They are categorized into canonical and noncanonical types and play pivotal roles in inflammatory responses and inflammation-associated diseases. Nonetheless, the regulatory roles of canonical and noncanonical inflammasomes, as well as how their dysregulation influences inflammation and disease, are largely unknown and require further investigation.

This Special Issue welcomes original research and comprehensive reviews to elucidate the regulatory functions and underlying molecular mechanisms of canonical and noncanonical inflammasomes in inflammatory responses and inflammation-associated diseases, aiming to advance the development of novel anti-inflammatory therapies targeting inflammasomes.

Potential topics include, but are not limited to:

1. Roles of canonical and noncanonical inflammasomes in inflammatory responses and diseases and the underlying molecular mechanisms
2. Identification and validation of novel molecules interacting with inflammasomes
3. Evaluation of anti-inflammatory effects through inflammasome targeting
4. Development of potential inflammasome-targeted therapeutics

 

Dr. Young-Su Yi
Guest Editor