Volume 31, Issue 2 (February 2026)

Genetic Modulation of Pluripotent Stem Cells

Open Access 24 Feb 2026Editorial

Genetic Modulation of Pluripotent Stem Cells

Balázs Sarkadi, Ágota Apáti

Front. Biosci. (Landmark Ed) 2026, 31(2), 50302; https://doi.org/10.31083/FBL50302

(This article belongs to the Special Issue Genetic Modulation of Human Pluripotent Stem Cells)

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181

Inter-laboratory Evaluation of γH2AX/53BP1 DNA Double-strand Break Foci Assays in Human Lymphocytes Under Low-dose Irradiation: Implications for Calyculin A

Open Access 24 Feb 2026Original Research

Inter-laboratory Evaluation of γH2AX/53BP1 DNA Double-strand Break Foci Assays in Human Lymphocytes Under Low-dose Irradiation: Implications for Calyculin A

Lucián Zastko, Lukáš Jakl, Jana Kružliaková, Petra Petrovičová

Front. Biosci. (Landmark Ed) 2026, 31(2), 47070; https://doi.org/10.31083/FBL47070

Abstract

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283

Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

Open Access 13 Feb 2026Original Research

Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

Wei Gong, Baiwei Zhang, Zuodong Yuan, Chansachak Chea, Fei Ye

Front. Biosci. (Landmark Ed) 2026, 31(2), 48473; https://doi.org/10.31083/FBL48473

Abstract

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239

ITPR2 Promotes Acute Myeloid Leukemia Progression Through Calcium-Mediated Mitochondrial Dysfunction

Open Access 13 Feb 2026Original Research

ITPR2 Promotes Acute Myeloid Leukemia Progression Through Calcium-Mediated Mitochondrial Dysfunction

Xiaoke Huang, Na Lu, Shanhu Zhu, Xiaolin Liang, Yiqian Huang, Jiamin Luo, Zhenfang Liu

Front. Biosci. (Landmark Ed) 2026, 31(2), 47824; https://doi.org/10.31083/FBL47824

Abstract

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316

Colorectal Cancer Puzzle: m6A Modification and Its Intricate Relationship With Drug Resistance

Open Access 13 Feb 2026Review

Colorectal Cancer Puzzle: m6A Modification and Its Intricate Relationship With Drug Resistance

Mengxiang Yang, Zhihui Dai, Yuejun Han, Yijing Shen, Jianping Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 45750; https://doi.org/10.31083/FBL45750

Abstract

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245

Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death

Open Access 12 Feb 2026Review

Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death

Reinhold Nafe, Elke Hattingen

Front. Biosci. (Landmark Ed) 2026, 31(2), 45799; https://doi.org/10.31083/FBL45799

Abstract

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301

Impact of Spheroid Use for Identifying Hepatocellular Carcinoma Features: Involvement of Kinase-Mediated Molecular Pathways

Open Access 12 Feb 2026Review

Impact of Spheroid Use for Identifying Hepatocellular Carcinoma Features: Involvement of Kinase-Mediated Molecular Pathways

Nicoletta Palermo, Giuseppe Pantò, Antonio Catalfamo, Alessia Filippone, Emanuela Esposito

Front. Biosci. (Landmark Ed) 2026, 31(2), 45980; https://doi.org/10.31083/FBL45980

Abstract

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191

Silencing the Mutant KCNH2 Allele to Reduce the Effects of Long QT Syndrome Type 2

Open Access 12 Feb 2026Original Research

Silencing the Mutant KCNH2 Allele to Reduce the Effects of Long QT Syndrome Type 2

Ronald Wilders

Front. Biosci. (Landmark Ed) 2026, 31(2), 49097; https://doi.org/10.31083/FBL49097

Abstract

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180

Signaling Pathway Remodeling and Molecular Regulation in the HCC TME: Dynamic Evolution and Clinical Therapeutic Advances

Open Access 12 Feb 2026Review

Signaling Pathway Remodeling and Molecular Regulation in the HCC TME: Dynamic Evolution and Clinical Therapeutic Advances

Lin Xu, Xuanhao Zhang, Hengzhou Zhu, Dong Niu, Xiaodan Zhu, Chunhui Jin

Front. Biosci. (Landmark Ed) 2026, 31(2), 45415; https://doi.org/10.31083/FBL45415

Abstract

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261

Electroacupuncture Facilitates the Regulation of Inflammation in the Conjunctiva of Rabbits With Dry Eye Syndrome via the α7nAChR-HMGB1 Signaling Pathway

Open Access 12 Feb 2026Original Research

Electroacupuncture Facilitates the Regulation of Inflammation in the Conjunctiva of Rabbits With Dry Eye Syndrome via the α7nAChR-HMGB1 Signaling Pathway

Ning Ding, Jie Zhang, Xia Wu, Shangjie Liang, Dandan Zhu, Mengting Huan, Lizhen Gan, Yunfeng Wu, Huxing Shen, Tengyan Ji, Yunchuan Wu, Qingbo Wei

Front. Biosci. (Landmark Ed) 2026, 31(2), 46689; https://doi.org/10.31083/FBL46689

Abstract

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238

Metabolic Portrait of Breast Cancer in Mixed Saliva

Open Access 12 Feb 2026Original Research

Metabolic Portrait of Breast Cancer in Mixed Saliva

Lyudmila V. Bel’skaya

Front. Biosci. (Landmark Ed) 2026, 31(2), 47739; https://doi.org/10.31083/FBL47739

Abstract

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163

Aerobic Running Training Attenuates Lipid and Protein Oxidation and Modulates Membrane Dynamics in Metabolically Active Tissues

Open Access 11 Feb 2026Original Research

Aerobic Running Training Attenuates Lipid and Protein Oxidation and Modulates Membrane Dynamics in Metabolically Active Tissues

Eduardo Piedrafita, Pablo Jesús Bascuas, Ana Vanessa Bataller-Cervero, César Berzosa

Front. Biosci. (Landmark Ed) 2026, 31(2), 47738; https://doi.org/10.31083/FBL47738

(This article belongs to the Special Issue Lipid Peroxidation)

Abstract

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288

Integrative Analysis of Glycine, Serine, and Threonine Metabolism and the Immune Microenvironment in Endometrial Cancer: A Prognostic Model and Metabolic-Immune Framework for Precision Oncology

Open Access 11 Feb 2026Original Research

Integrative Analysis of Glycine, Serine, and Threonine Metabolism and the Immune Microenvironment in Endometrial Cancer: A Prognostic Model and Metabolic-Immune Framework for Precision Oncology

Jingxuan Ye, Yashi Shi, Xite Lin, Maotong Zhang, Xiaodan Mao, Pengming Sun

Front. Biosci. (Landmark Ed) 2026, 31(2), 48779; https://doi.org/10.31083/FBL48779

Abstract

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239

Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease

Open Access 11 Feb 2026Review

Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease

Caterina Gagliano, Alessandro Avitabile, Dario Rusciano

Front. Biosci. (Landmark Ed) 2026, 31(2), 46738; https://doi.org/10.31083/FBL46738

Abstract

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271

Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis

Open Access 10 Feb 2026Original Research

Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis

Yanzhe Wang, Ying Jing, Liuyi Yang, Dongping Chen, Guiqun Wu, Ming Wu, Lin Li

Front. Biosci. (Landmark Ed) 2026, 31(2), 47847; https://doi.org/10.31083/FBL47847

Abstract

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262

MCC950 Suppresses Hepatic Inflammaging by Inhibiting NLRP3 Inflammasome Activation in Spontaneously Aged Mice

Open Access 10 Feb 2026Original Research

MCC950 Suppresses Hepatic Inflammaging by Inhibiting NLRP3 Inflammasome Activation in Spontaneously Aged Mice

Kyung-Hyun Kim, Young-Wook Seo, Yae-Ji Kim, Hui-Ju Lee, Jin-Li Ryu, Hyun-Tae Kim, Geum-Lan Hong, Ju-Young Jung

Front. Biosci. (Landmark Ed) 2026, 31(2), 49153; https://doi.org/10.31083/FBL49153

Abstract

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271

A Self-Assembled Nanobody Against the Haemagglutinin of Influenza a Virus Shows Enhanced Stability and Efficacy In Vitro and In Vivo

Open Access 10 Feb 2026Original Research

A Self-Assembled Nanobody Against the Haemagglutinin of Influenza a Virus Shows Enhanced Stability and Efficacy In Vitro and In Vivo

Qian Weng, Honggang Liu, Xue Yan, Cheng Xu, Qin Wang, Yifan Xu, Junwei Li

Front. Biosci. (Landmark Ed) 2026, 31(2), 47298; https://doi.org/10.31083/FBL47298

Abstract

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263

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury

Open Access 10 Feb 2026Original Research

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury

Fanjie Lin, Elena Pineda, Bethany McGonnigal, Joselynn Wallace, Wenju Lu, Phyllis A. Dennery, Hongwei Yao

Front. Biosci. (Landmark Ed) 2026, 31(2), 48370; https://doi.org/10.31083/FBL48370

Abstract

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383

WDR4 is a Potential Indicator of Clinical Diagnostics, Prognosis, and Immunotherapy in Hepatocellular Carcinoma (HCC)

Open Access 9 Feb 2026Original Research

WDR4 is a Potential Indicator of Clinical Diagnostics, Prognosis, and Immunotherapy in Hepatocellular Carcinoma (HCC)

Liyao Yang, Juan Wang, Yao Zhang, Min Li, Mazaher Maghsoudloo, Junjiang Fu, Shasha Fan, Jingjing Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 45764; https://doi.org/10.31083/FBL45764

Abstract

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201

Prevalence and Molecular Characterization of β-Lactamase and Quinolone Resistance Genes in Imipenem-Non-Susceptible Uropathogenic Escherichia coli (UPEC) Isolates

Open Access 9 Feb 2026Original Research

Prevalence and Molecular Characterization of β-Lactamase and Quinolone Resistance Genes in Imipenem-Non-Susceptible Uropathogenic Escherichia coli (UPEC) Isolates

Anfal Kara, Chiara Massaro, Naouel Boussoualim, Meriem Elkolli, Rosa Alduina

Front. Biosci. (Landmark Ed) 2026, 31(2), 48045; https://doi.org/10.31083/FBL48045

Abstract

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230

Insulin-Like Growth Factor 1 in Exosomes Derived from Adipose-Derived Stem Cells Promotes Tendon-Bone Healing in Rotator Cuff Injuries

Open Access 6 Feb 2026Original Research

Insulin-Like Growth Factor 1 in Exosomes Derived from Adipose-Derived Stem Cells Promotes Tendon-Bone Healing in Rotator Cuff Injuries

Wenxiao Qi, Yiren Jin, Haojie Shan, Ye Lu, Feng Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 47168; https://doi.org/10.31083/FBL47168

Abstract

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195

Applications of Natural Coumarins in Bone and Joint Diseases: Pharmacological Mechanisms and Advances in Clinical Research

Open Access 6 Feb 2026Review

Applications of Natural Coumarins in Bone and Joint Diseases: Pharmacological Mechanisms and Advances in Clinical Research

Jianhui Ma, Wenjiao Wang, Xudong Zhang, Lu Wang, Zhengqi Liu, Cong Huang

Front. Biosci. (Landmark Ed) 2026, 31(2), 46784; https://doi.org/10.31083/FBL46784

Abstract

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223

LXN-THBS2 Signaling Axis Regulates Hepatic Stellate Cell Activation and Promotes the Development of Liver Fibrosis

Open Access 6 Feb 2026Original Research

LXN-THBS2 Signaling Axis Regulates Hepatic Stellate Cell Activation and Promotes the Development of Liver Fibrosis

Haoyan Wang, Hanyu Jiang, Suyi Wang, Xinru Luo, Xi Tan, Donglin Cao, Yachao Yao

Front. Biosci. (Landmark Ed) 2026, 31(2), 46251; https://doi.org/10.31083/FBL46251

Abstract

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276

Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis

Open Access 5 Feb 2026Original Research

Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis

Zhibo Guo, Zengliang Gao, Yanqiu Zhao, Xiaoting Ni, Wenlei Zhang, Longyu Li, Shiao Ren, Qi Li, Dan Guo, Lijuan Yue, Yutong Liu, Liwang Lin, Shengjin Fan, Xin Hai

Front. Biosci. (Landmark Ed) 2026, 31(2), 48584; https://doi.org/10.31083/FBL48584

Abstract

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205

Ferroptosis Induction is Insufficient to Ensure NK Cell Activation in High-Grade Ovarian Cancer

Open Access 5 Feb 2026Original Research

Ferroptosis Induction is Insufficient to Ensure NK Cell Activation in High-Grade Ovarian Cancer

Cinzia Garofalo, Stefania Scicchitano, Eleonora Vecchio, Antonia Nisticò, Barbara Quaresima, Beatrice Stella, Carmela De Marco, Flavia Biamonte, Maria Concetta Faniello

Front. Biosci. (Landmark Ed) 2026, 31(2), 46641; https://doi.org/10.31083/FBL46641

Abstract

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272

METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis

Open Access 3 Feb 2026Original Research

METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis

Li He, Xing Tong, Ming Yang, Xiaoming Wang, Xiaowei Wang, Bing Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 45159; https://doi.org/10.31083/FBL45159

Abstract

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238

A Unique Perspective on Auto-reactive Antibody Production in Autoimmune Disease Induced by Microbiome

Open Access 31 Jan 2026Review

A Unique Perspective on Auto-reactive Antibody Production in Autoimmune Disease Induced by Microbiome

Liting Yan, Jun Hu, Qing Feng, Jingying Sun, Xiaoyan Huang, Cuixiang Xu

Front. Biosci. (Landmark Ed) 2026, 31(2), 45424; https://doi.org/10.31083/FBL45424

Abstract

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208

Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance

Open Access 31 Jan 2026Review

Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance

Zhijie Yin, Qingfu Lang, Peng Xiao, Chen Jia, Jia Sun, Tiemin Pei

Front. Biosci. (Landmark Ed) 2026, 31(2), 44550; https://doi.org/10.31083/FBL44550

Abstract

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185

Ion Channel Dysregulation in Neurodevelopmental Disorders: Mechanisms, Models, and Therapeutic Advances

Open Access 31 Jan 2026Review

Ion Channel Dysregulation in Neurodevelopmental Disorders: Mechanisms, Models, and Therapeutic Advances

Zihan Shi, Shanshan Li, Xin Jin

Front. Biosci. (Landmark Ed) 2026, 31(2), 43770; https://doi.org/10.31083/FBL43770

(This article belongs to the Special Issue Exploring Pathomechanisms, Novel Targets, and New Interventions of Neurological and Neuropsychiatric Disorders - Volume 2)

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671

Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence

Open Access 31 Jan 2026Original Research

Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence

Yan Zeng, Lanqin Liu, Jing Liu, Qulian Guo, Kaixuan Zeng, Yangchun Liu, Yongqi Bai, Yanling Jin, Xiaoli Zheng, Wenjun Liu, Ling Guo

Front. Biosci. (Landmark Ed) 2026, 31(2), 48325; https://doi.org/10.31083/FBL48325

(This article belongs to the Special Issue Natural Antioxidants: Therapeutic Advances in Inflammatory Disorders and Cancer)

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312

Volume 31, Issue 2 (2026)

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Article

Genetic Modulation of Pluripotent Stem Cells

Open Access 24 Feb 2026Editorial

Genetic Modulation of Pluripotent Stem Cells

Balázs Sarkadi, Ágota Apáti

Front. Biosci. (Landmark Ed) 2026, 31(2), 50302; https://doi.org/10.31083/FBL50302

(This article belongs to the Special Issue Genetic Modulation of Human Pluripotent Stem Cells)

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181

Inter-laboratory Evaluation of γH2AX/53BP1 DNA Double-strand Break Foci Assays in Human Lymphocytes Under Low-dose Irradiation: Implications for Calyculin A

Open Access 24 Feb 2026Original Research

Inter-laboratory Evaluation of γH2AX/53BP1 DNA Double-strand Break Foci Assays in Human Lymphocytes Under Low-dose Irradiation: Implications for Calyculin A

Lucián Zastko, Lukáš Jakl, Jana Kružliaková, Petra Petrovičová

Front. Biosci. (Landmark Ed) 2026, 31(2), 47070; https://doi.org/10.31083/FBL47070

Abstract

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283

Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

Open Access 13 Feb 2026Original Research

Bevacizumab-Primed Vascular Normalization Enhances Intratumoral Delivery and Efficacy of the tBID-Armed Oncolytic Adenovirus KD01 in Glioma

Wei Gong, Baiwei Zhang, Zuodong Yuan, Chansachak Chea, Fei Ye

Front. Biosci. (Landmark Ed) 2026, 31(2), 48473; https://doi.org/10.31083/FBL48473

Abstract

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239

ITPR2 Promotes Acute Myeloid Leukemia Progression Through Calcium-Mediated Mitochondrial Dysfunction

Open Access 13 Feb 2026Original Research

ITPR2 Promotes Acute Myeloid Leukemia Progression Through Calcium-Mediated Mitochondrial Dysfunction

Xiaoke Huang, Na Lu, Shanhu Zhu, Xiaolin Liang, Yiqian Huang, Jiamin Luo, Zhenfang Liu

Front. Biosci. (Landmark Ed) 2026, 31(2), 47824; https://doi.org/10.31083/FBL47824

Abstract

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316

Colorectal Cancer Puzzle: m6A Modification and Its Intricate Relationship With Drug Resistance

Open Access 13 Feb 2026Review

Colorectal Cancer Puzzle: m6A Modification and Its Intricate Relationship With Drug Resistance

Mengxiang Yang, Zhihui Dai, Yuejun Han, Yijing Shen, Jianping Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 45750; https://doi.org/10.31083/FBL45750

Abstract

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245

Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death

Open Access 12 Feb 2026Review

Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death

Reinhold Nafe, Elke Hattingen

Front. Biosci. (Landmark Ed) 2026, 31(2), 45799; https://doi.org/10.31083/FBL45799

Abstract

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301

Impact of Spheroid Use for Identifying Hepatocellular Carcinoma Features: Involvement of Kinase-Mediated Molecular Pathways

Open Access 12 Feb 2026Review

Impact of Spheroid Use for Identifying Hepatocellular Carcinoma Features: Involvement of Kinase-Mediated Molecular Pathways

Nicoletta Palermo, Giuseppe Pantò, Antonio Catalfamo, Alessia Filippone, Emanuela Esposito

Front. Biosci. (Landmark Ed) 2026, 31(2), 45980; https://doi.org/10.31083/FBL45980

Abstract

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191

Silencing the Mutant KCNH2 Allele to Reduce the Effects of Long QT Syndrome Type 2

Open Access 12 Feb 2026Original Research

Silencing the Mutant KCNH2 Allele to Reduce the Effects of Long QT Syndrome Type 2

Ronald Wilders

Front. Biosci. (Landmark Ed) 2026, 31(2), 49097; https://doi.org/10.31083/FBL49097

Abstract

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180

Signaling Pathway Remodeling and Molecular Regulation in the HCC TME: Dynamic Evolution and Clinical Therapeutic Advances

Open Access 12 Feb 2026Review

Signaling Pathway Remodeling and Molecular Regulation in the HCC TME: Dynamic Evolution and Clinical Therapeutic Advances

Lin Xu, Xuanhao Zhang, Hengzhou Zhu, Dong Niu, Xiaodan Zhu, Chunhui Jin

Front. Biosci. (Landmark Ed) 2026, 31(2), 45415; https://doi.org/10.31083/FBL45415

Abstract

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261

Electroacupuncture Facilitates the Regulation of Inflammation in the Conjunctiva of Rabbits With Dry Eye Syndrome via the α7nAChR-HMGB1 Signaling Pathway

Open Access 12 Feb 2026Original Research

Electroacupuncture Facilitates the Regulation of Inflammation in the Conjunctiva of Rabbits With Dry Eye Syndrome via the α7nAChR-HMGB1 Signaling Pathway

Ning Ding, Jie Zhang, Xia Wu, Shangjie Liang, Dandan Zhu, Mengting Huan, Lizhen Gan, Yunfeng Wu, Huxing Shen, Tengyan Ji, Yunchuan Wu, Qingbo Wei

Front. Biosci. (Landmark Ed) 2026, 31(2), 46689; https://doi.org/10.31083/FBL46689

Abstract

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238

Metabolic Portrait of Breast Cancer in Mixed Saliva

Open Access 12 Feb 2026Original Research

Metabolic Portrait of Breast Cancer in Mixed Saliva

Lyudmila V. Bel’skaya

Front. Biosci. (Landmark Ed) 2026, 31(2), 47739; https://doi.org/10.31083/FBL47739

Abstract

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163

Aerobic Running Training Attenuates Lipid and Protein Oxidation and Modulates Membrane Dynamics in Metabolically Active Tissues

Open Access 11 Feb 2026Original Research

Aerobic Running Training Attenuates Lipid and Protein Oxidation and Modulates Membrane Dynamics in Metabolically Active Tissues

Eduardo Piedrafita, Pablo Jesús Bascuas, Ana Vanessa Bataller-Cervero, César Berzosa

Front. Biosci. (Landmark Ed) 2026, 31(2), 47738; https://doi.org/10.31083/FBL47738

(This article belongs to the Special Issue Lipid Peroxidation)

Abstract

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288

Integrative Analysis of Glycine, Serine, and Threonine Metabolism and the Immune Microenvironment in Endometrial Cancer: A Prognostic Model and Metabolic-Immune Framework for Precision Oncology

Open Access 11 Feb 2026Original Research

Integrative Analysis of Glycine, Serine, and Threonine Metabolism and the Immune Microenvironment in Endometrial Cancer: A Prognostic Model and Metabolic-Immune Framework for Precision Oncology

Jingxuan Ye, Yashi Shi, Xite Lin, Maotong Zhang, Xiaodan Mao, Pengming Sun

Front. Biosci. (Landmark Ed) 2026, 31(2), 48779; https://doi.org/10.31083/FBL48779

Abstract

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239

Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease

Open Access 11 Feb 2026Review

Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease

Caterina Gagliano, Alessandro Avitabile, Dario Rusciano

Front. Biosci. (Landmark Ed) 2026, 31(2), 46738; https://doi.org/10.31083/FBL46738

Abstract

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271

Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis

Open Access 10 Feb 2026Original Research

Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis

Yanzhe Wang, Ying Jing, Liuyi Yang, Dongping Chen, Guiqun Wu, Ming Wu, Lin Li

Front. Biosci. (Landmark Ed) 2026, 31(2), 47847; https://doi.org/10.31083/FBL47847

Abstract

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262

MCC950 Suppresses Hepatic Inflammaging by Inhibiting NLRP3 Inflammasome Activation in Spontaneously Aged Mice

Open Access 10 Feb 2026Original Research

MCC950 Suppresses Hepatic Inflammaging by Inhibiting NLRP3 Inflammasome Activation in Spontaneously Aged Mice

Kyung-Hyun Kim, Young-Wook Seo, Yae-Ji Kim, Hui-Ju Lee, Jin-Li Ryu, Hyun-Tae Kim, Geum-Lan Hong, Ju-Young Jung

Front. Biosci. (Landmark Ed) 2026, 31(2), 49153; https://doi.org/10.31083/FBL49153

Abstract

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271

A Self-Assembled Nanobody Against the Haemagglutinin of Influenza a Virus Shows Enhanced Stability and Efficacy In Vitro and In Vivo

Open Access 10 Feb 2026Original Research

A Self-Assembled Nanobody Against the Haemagglutinin of Influenza a Virus Shows Enhanced Stability and Efficacy In Vitro and In Vivo

Qian Weng, Honggang Liu, Xue Yan, Cheng Xu, Qin Wang, Yifan Xu, Junwei Li

Front. Biosci. (Landmark Ed) 2026, 31(2), 47298; https://doi.org/10.31083/FBL47298

Abstract

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263

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury

Open Access 10 Feb 2026Original Research

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury

Fanjie Lin, Elena Pineda, Bethany McGonnigal, Joselynn Wallace, Wenju Lu, Phyllis A. Dennery, Hongwei Yao

Front. Biosci. (Landmark Ed) 2026, 31(2), 48370; https://doi.org/10.31083/FBL48370

Abstract

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383

WDR4 is a Potential Indicator of Clinical Diagnostics, Prognosis, and Immunotherapy in Hepatocellular Carcinoma (HCC)

Open Access 9 Feb 2026Original Research

WDR4 is a Potential Indicator of Clinical Diagnostics, Prognosis, and Immunotherapy in Hepatocellular Carcinoma (HCC)

Liyao Yang, Juan Wang, Yao Zhang, Min Li, Mazaher Maghsoudloo, Junjiang Fu, Shasha Fan, Jingjing Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 45764; https://doi.org/10.31083/FBL45764

Abstract

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201

Prevalence and Molecular Characterization of β-Lactamase and Quinolone Resistance Genes in Imipenem-Non-Susceptible Uropathogenic Escherichia coli (UPEC) Isolates

Open Access 9 Feb 2026Original Research

Prevalence and Molecular Characterization of β-Lactamase and Quinolone Resistance Genes in Imipenem-Non-Susceptible Uropathogenic Escherichia coli (UPEC) Isolates

Anfal Kara, Chiara Massaro, Naouel Boussoualim, Meriem Elkolli, Rosa Alduina

Front. Biosci. (Landmark Ed) 2026, 31(2), 48045; https://doi.org/10.31083/FBL48045

Abstract

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230

Insulin-Like Growth Factor 1 in Exosomes Derived from Adipose-Derived Stem Cells Promotes Tendon-Bone Healing in Rotator Cuff Injuries

Open Access 6 Feb 2026Original Research

Insulin-Like Growth Factor 1 in Exosomes Derived from Adipose-Derived Stem Cells Promotes Tendon-Bone Healing in Rotator Cuff Injuries

Wenxiao Qi, Yiren Jin, Haojie Shan, Ye Lu, Feng Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 47168; https://doi.org/10.31083/FBL47168

Abstract

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195

Applications of Natural Coumarins in Bone and Joint Diseases: Pharmacological Mechanisms and Advances in Clinical Research

Open Access 6 Feb 2026Review

Applications of Natural Coumarins in Bone and Joint Diseases: Pharmacological Mechanisms and Advances in Clinical Research

Jianhui Ma, Wenjiao Wang, Xudong Zhang, Lu Wang, Zhengqi Liu, Cong Huang

Front. Biosci. (Landmark Ed) 2026, 31(2), 46784; https://doi.org/10.31083/FBL46784

Abstract

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223

LXN-THBS2 Signaling Axis Regulates Hepatic Stellate Cell Activation and Promotes the Development of Liver Fibrosis

Open Access 6 Feb 2026Original Research

LXN-THBS2 Signaling Axis Regulates Hepatic Stellate Cell Activation and Promotes the Development of Liver Fibrosis

Haoyan Wang, Hanyu Jiang, Suyi Wang, Xinru Luo, Xi Tan, Donglin Cao, Yachao Yao

Front. Biosci. (Landmark Ed) 2026, 31(2), 46251; https://doi.org/10.31083/FBL46251

Abstract

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276

Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis

Open Access 5 Feb 2026Original Research

Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis

Zhibo Guo, Zengliang Gao, Yanqiu Zhao, Xiaoting Ni, Wenlei Zhang, Longyu Li, Shiao Ren, Qi Li, Dan Guo, Lijuan Yue, Yutong Liu, Liwang Lin, Shengjin Fan, Xin Hai

Front. Biosci. (Landmark Ed) 2026, 31(2), 48584; https://doi.org/10.31083/FBL48584

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205

Ferroptosis Induction is Insufficient to Ensure NK Cell Activation in High-Grade Ovarian Cancer

Open Access 5 Feb 2026Original Research

Ferroptosis Induction is Insufficient to Ensure NK Cell Activation in High-Grade Ovarian Cancer

Cinzia Garofalo, Stefania Scicchitano, Eleonora Vecchio, Antonia Nisticò, Barbara Quaresima, Beatrice Stella, Carmela De Marco, Flavia Biamonte, Maria Concetta Faniello

Front. Biosci. (Landmark Ed) 2026, 31(2), 46641; https://doi.org/10.31083/FBL46641

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272

METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis

Open Access 3 Feb 2026Original Research

METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis

Li He, Xing Tong, Ming Yang, Xiaoming Wang, Xiaowei Wang, Bing Wang

Front. Biosci. (Landmark Ed) 2026, 31(2), 45159; https://doi.org/10.31083/FBL45159

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238

A Unique Perspective on Auto-reactive Antibody Production in Autoimmune Disease Induced by Microbiome

Open Access 31 Jan 2026Review

A Unique Perspective on Auto-reactive Antibody Production in Autoimmune Disease Induced by Microbiome

Liting Yan, Jun Hu, Qing Feng, Jingying Sun, Xiaoyan Huang, Cuixiang Xu

Front. Biosci. (Landmark Ed) 2026, 31(2), 45424; https://doi.org/10.31083/FBL45424

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208

Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance

Open Access 31 Jan 2026Review

Diverse Biological Functions of IGF2BPs in Hepatobiliary Cancers and Their Clinical Relevance

Zhijie Yin, Qingfu Lang, Peng Xiao, Chen Jia, Jia Sun, Tiemin Pei

Front. Biosci. (Landmark Ed) 2026, 31(2), 44550; https://doi.org/10.31083/FBL44550

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185

Ion Channel Dysregulation in Neurodevelopmental Disorders: Mechanisms, Models, and Therapeutic Advances

Open Access 31 Jan 2026Review

Ion Channel Dysregulation in Neurodevelopmental Disorders: Mechanisms, Models, and Therapeutic Advances

Zihan Shi, Shanshan Li, Xin Jin

Front. Biosci. (Landmark Ed) 2026, 31(2), 43770; https://doi.org/10.31083/FBL43770

(This article belongs to the Special Issue Exploring Pathomechanisms, Novel Targets, and New Interventions of Neurological and Neuropsychiatric Disorders - Volume 2)

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671

Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence

Open Access 31 Jan 2026Original Research

Ferroptosis Induction by Purple Sweet Potato Anthocyanins in T-cell Acute Lymphoblastic Leukemia: Combined Molecular Docking, In Vitro, and In Vivo Evidence

Yan Zeng, Lanqin Liu, Jing Liu, Qulian Guo, Kaixuan Zeng, Yangchun Liu, Yongqi Bai, Yanling Jin, Xiaoli Zheng, Wenjun Liu, Ling Guo

Front. Biosci. (Landmark Ed) 2026, 31(2), 48325; https://doi.org/10.31083/FBL48325

(This article belongs to the Special Issue Natural Antioxidants: Therapeutic Advances in Inflammatory Disorders and Cancer)

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312