Volume 29 Issue 1 2024

• Open Access Original Research

  Early Estrogen Replacement Therapy Attenuates Cardiac Dysfunction Caused by Aging and Ovariectomy in Female Wistar Rats

  Diana Ramírez-Hernández, Pedro López-Sanchez, Diego Lezama-Martínez, Erik Pérez-García, ... Jazmin Flores-Monroy

  Front. Biosci. (Landmark Ed) 2024, 29(1), 46; https://doi.org/10.31083/j.fbl2901046

  (This article belongs to the Special Issue Lipids and lipid metabolism in cardiovascular disease)

  Abstract Full Text PDF(7.25MB)

  79

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  304

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• Open Access Review

  Ferroptosis: New Strategies and Ideas for the Treatment of Pancreatic Ductal Adenocarcinoma

  Chengru Yang, Qingfu Dong, Haolin Bao, Yifei Ge, ... Xiangyu Zhong

  Front. Biosci. (Landmark Ed) 2024, 29(1), 45; https://doi.org/10.31083/j.fbl2901045

  Abstract Full Text PDF(2.70MB)

  105

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  241

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• Open Access Original Research

  MiR-145 Alleviates Sepsis-Induced Inflammatory Responses and Organ Injury by Targeting ADAM17

  Yingying Lin, Lizhen Liu, Yao Lin, Ruoxuan Yang, ... Qinghua Liu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 44; https://doi.org/10.31083/j.fbl2901044

  (This article belongs to the Special Issue The Pathogenesis of Sepsis)

  Abstract Full Text PDF(13.78MB)

  56

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  188

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• Open Access Original Research

  Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies

  Mohd Nazam Ansari, Najeeb Ur Rehman, Abdul Samad, Wasim Ahmad

  Front. Biosci. (Landmark Ed) 2024, 29(1), 43; https://doi.org/10.31083/j.fbl2901043

  Abstract Full Text PDF(1.28MB)

  36

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  140

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• Open Access Review

  Novel Targeted Therapies for Rheumatoid Arthritis Based on Intracellular Signalling and Immunometabolic Changes: A Narrative Review

  Marveh Rahmati, Maria Paula Kwesiga, Jiachen Lou, Ai Lyn Tan, Michael F McDermott

  Front. Biosci. (Landmark Ed) 2024, 29(1), 42; https://doi.org/10.31083/j.fbl2901042

  Abstract Full Text PDF(2.99MB)

  184

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  509

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• Open Access Original Research

  Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target

  Shilpee Chanda, Konstantin Lepikhov, Charlotte Dahlem, Hanna S. Schymik, ... Alexandra K. Kiemer

  Front. Biosci. (Landmark Ed) 2024, 29(1), 41; https://doi.org/10.31083/j.fbl2901041

  (This article belongs to the Special Issue New Targets in Anticancer Therapy)

  Abstract Full Text PDF(5.36MB)

  42

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  176

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• Open Access Original Research

  Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway

  Kalyani Patil, Abdul Q Khan, Fareed Ahmad, Shilpa Kuttikrishnan, ... Shahab Uddin

  Front. Biosci. (Landmark Ed) 2024, 29(1), 40; https://doi.org/10.31083/j.fbl2901040

  Abstract Full Text PDF(8.33MB)

  52

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  185

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• Open Access Original Research

  Bioinformatics Analysis Identifies PLA2G7 as a Key Antigen-Presenting Prognostic Related Gene Promoting Hepatocellular Carcinoma through the STAT1/PD-L1 Axis

  Sihang Guo, Qinhe Yang

  Front. Biosci. (Landmark Ed) 2024, 29(1), 39; https://doi.org/10.31083/j.fbl2901039

  (This article belongs to the Special Issue Targeting of Multiple Predictive Biomarkers for Checkpoint Immunotherapy)

  Abstract Full Text PDF(9.18MB)

  34

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  157

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• Open Access Original Research

  High-Throughput Sequencing to Investigate the Expression and Potential Role of Differentially Expressed microRNAs in Myocardial Cells after Ischemia-Reperfusion Injury

  Senjie Li, Dongqing Lv, Yan Lu, Yanwei Zhang, Yongping Jia

  Front. Biosci. (Landmark Ed) 2024, 29(1), 38; https://doi.org/10.31083/j.fbl2901038

  Abstract Full Text PDF(11.69MB)

  17

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  90

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• Open Access Review

  Recent Advance of S100B Proteins in Spontaneous Intracerebral Hemorrhage and Aneurysmal Subarachnoid Hemorrhage

  Zhang-Ming Zhou, Ling-Ling Gu, Zhe-Yu Zhou, Qing-Le Liang

  Front. Biosci. (Landmark Ed) 2024, 29(1), 37; https://doi.org/10.31083/j.fbl2901037

  Abstract Full Text PDF(699.35KB)

  42

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  146

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• Open Access Review

  Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease

  Alexander Blagov, Anton Postnov, Vasily Sukhorukov, Mikhail Popov, ... Alexander Orekhov

  Front. Biosci. (Landmark Ed) 2024, 29(1), 36; https://doi.org/10.31083/j.fbl2901036

  Abstract Full Text PDF(3.94MB)

  95

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  263

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• Open Access Original Research

  Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway

  Jie Wang, Ze Yu, Yixiao Jiang, Ting Le, ... Haijie Ma

  Front. Biosci. (Landmark Ed) 2024, 29(1), 35; https://doi.org/10.31083/j.fbl2901035

  Abstract Full Text PDF(5.31MB)

  33

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  146

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• Open Access Review

  Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells

  Min Ma, Jian-Yun Ge, Yun-Zhong Nie, Yu-Mei Li, Yun-Wen Zheng

  Front. Biosci. (Landmark Ed) 2024, 29(1), 34; https://doi.org/10.31083/j.fbl2901034

  Abstract Full Text PDF(3.95MB)

  89

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  172

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• Open Access Original Research

  N⁶-Methyladenosine Regulator-Mediated Methylation Modification Patterns with Distinct Prognosis, Oxidative Stress, and Tumor Microenvironment in Renal Cell Carcinoma

  Chunyang Li, Maoshu Zhu, Chuane Gao, Fuhua Lu, ... Weimin Zhong

  Front. Biosci. (Landmark Ed) 2024, 29(1), 33; https://doi.org/10.31083/j.fbl2901033

  (This article belongs to the Special Issue Targeting of Multiple Predictive Biomarkers for Checkpoint Immunotherapy)

  Abstract Full Text PDF(18.41MB)

  18

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  98

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• Open Access Original Research

  O-glycoprofiling of Serum Apolipoprotein C-III in Colorectal Cancer

  Kristína Kianičková, Zuzana Pakanová, Filip Květoň, Alena Holazová, ... Jaroslav Katrlík

  Front. Biosci. (Landmark Ed) 2024, 29(1), 32; https://doi.org/10.31083/j.fbl2901032

  (This article belongs to the Special Issue Gastrointestinal Cancer: Pathogenesis, Carcinogenesis and Targeted Therapies)

  Abstract Full Text PDF(1.11MB)

  37

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  137

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• Open Access Original Research

  Protective Properties of Botanical Extracts against 5G Radiation-induced Damage to Human Skin, as Demonstrated in Preliminary Data from a Keratinocyte Cell Culture Model

  Fabien Havas, Moshe Cohen, Shlomo Krispin, Joan Attia-Vigneau

  Front. Biosci. (Landmark Ed) 2024, 29(1), 31; https://doi.org/10.31083/j.fbl2901031

  (This article belongs to the Special Issue Antiaging in Dermatology)

  Abstract Full Text PDF(6.54MB)

  76

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  235

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• Open Access Review

  Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease

  Shuangshuang Zhao, Yan Guo, Xunzhe Yin

  Front. Biosci. (Landmark Ed) 2024, 29(1), 30; https://doi.org/10.31083/j.fbl2901030

  (This article belongs to the Special Issue Cellular and Molecular Mechanisms of Metabolic Liver Disease-associated Hepatocellular Carcinoma)

  Abstract Full Text PDF(12.48MB)

  129

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  219

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• Open Access Original Research

  Cytokine Profiling in Aqueous Humor of Glaucoma Patients and in Retinas from an Ex Vivo Glaucoma Animal Model

  Jiancen Tang, Mengsha Sun, Yuan Feng, Verena Prokosch, ... Hanhan Liu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 29; https://doi.org/10.31083/j.fbl2901029

  (This article belongs to the Special Issue Retinal Biology in Health and Disease)

  Abstract Full Text PDF(2.66MB)

  32

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  118

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• Open Access Original Research

  The Centrosomes of Haploid and Diploid Cells Have an Equal Number of Centrioles in the Parasitoid Wasp Anisopteromalus Calandrae

  Rustem Uzbekov, San-Whouly Mauricette Ouali N'goran, Anastasiia Garanina, Massimo Pancione, ... Christophe Bressac

  Front. Biosci. (Landmark Ed) 2024, 29(1), 28; https://doi.org/10.31083/j.fbl2901028

  Abstract Full Text PDF(7.42MB)

  34

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  132

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• Open Access Original Research

  KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2

  Qiaohong Bai, Wenfang Jin, Futao Chen, Jiang Zhu, ... Li Li

  Front. Biosci. (Landmark Ed) 2024, 29(1), 27; https://doi.org/10.31083/j.fbl2901027

  Abstract Full Text PDF(21.99MB)

  37

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  103

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• Open Access Review

  The Regulatory Role and Mechanism of Energy Metabolism in Vascular Diseases

  Taoli Sun, Wei Yuan, Yu Wei, Duanfang Liao, Qinhui Tuo

  Front. Biosci. (Landmark Ed) 2024, 29(1), 26; https://doi.org/10.31083/j.fbl2901026

  Abstract Full Text PDF(2.88MB)

  73

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  219

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• Open Access Original Research

  Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells

  Qi Zhao, Yadi Lan, Xiuju Shi, Xiangfei Sun

  Front. Biosci. (Landmark Ed) 2024, 29(1), 25; https://doi.org/10.31083/j.fbl2901025

  Abstract Full Text PDF(10.57MB)

  21

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  79

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• Open Access Review

  Polycystic Ovary Syndrome Pathophysiology: Integrating Systemic, CNS and Circadian Processes

  George Anderson

  Front. Biosci. (Landmark Ed) 2024, 29(1), 24; https://doi.org/10.31083/j.fbl2901024

  Abstract Full Text PDF(1.74MB)

  129

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  295

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• Open Access Review

  Advancements in the ERK1/2 Signaling Pathway Affecting Male Reproduction

  Yikuan Du, Xianhong Chi, Yuni Wang, Xiaolin Cai, ... Chun Yang

  Front. Biosci. (Landmark Ed) 2024, 29(1), 23; https://doi.org/10.31083/j.fbl2901023

  Abstract Full Text PDF(7.24MB)

  49

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  160

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• Open Access Review

  Unveiling the Intricacies of Autophagy in Asthma: Unraveling Novel Therapeutic Avenues

  Junjun Peng, Na Lu, Shucheng Hua, Lei Song, Han Liu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 22; https://doi.org/10.31083/j.fbl2901022

  (This article belongs to the Special Issue Molecular Mechanisms of Inflammatory and Metabolic Diseases)

  Abstract Full Text PDF(2.02MB)

  39

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  102

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• Open Access Original Research

  Identifying Autophagy-Associated Proteins and Chemicals with a Random Walk-Based Method within Heterogeneous Interaction Network

  FeiMing Huang, Wei Guo, Lei Chen, KaiYan Feng, ... Yu-Dong Cai

  Front. Biosci. (Landmark Ed) 2024, 29(1), 21; https://doi.org/10.31083/j.fbl2901021

  Abstract Full Text PDF(2.40MB)

  25

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  95

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• Open Access Review

  Machine and Deep Learning: Artificial Intelligence Application in Biotic and Abiotic Stress Management in Plants

  Caiming Gou, Sara Zafar, Fatima , Zuhair Hasnain, ... Manzar Abbas

  Front. Biosci. (Landmark Ed) 2024, 29(1), 20; https://doi.org/10.31083/j.fbl2901020

  Abstract Full Text PDF(923.82KB)

  182

  Downloads

  201

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• Open Access Original Research

  Novel Signaling Pathway and NSC689534 as a Potential Drug Candidate for Cutaneous Squamous Cell Carcinoma

  Ying Miao, Cheng Shen, Xin Zhang, Qi-Qi Li, ... Xiao-Dong Chen

  Front. Biosci. (Landmark Ed) 2024, 29(1), 19; https://doi.org/10.31083/j.fbl2901019

  Abstract Full Text PDF(9.08MB)

  30

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  104

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• Open Access Original Research

  A Case-Control Study of the Associations between EGLN1 Gene Polymorphisms and COPD

  Xin Li, Peng Zhang, Jing Yu, Chunyan Zhang, ... Xinhua Wang

  Front. Biosci. (Landmark Ed) 2024, 29(1), 18; https://doi.org/10.31083/j.fbl2901018

  Abstract Full Text PDF(258.17KB)

  22

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  83

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• Open Access Review

  ACE2 Regulates Glycolipid Metabolism in Multiple Tissues

  Rui Li, Fangyu Li, Li Yuan

  Front. Biosci. (Landmark Ed) 2024, 29(1), 17; https://doi.org/10.31083/j.fbl2901017

  Abstract Full Text PDF(884.95KB)

  53

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  156

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• Open Access Original Research

  Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer

  Orlando Vargas-Sierra, Jennifer Hernández-Juárez, Perla Yaceli Uc-Uc, Luis A Herrera, ... José Díaz-Chávez

  Front. Biosci. (Landmark Ed) 2024, 29(1), 16; https://doi.org/10.31083/j.fbl2901016

  Abstract Full Text PDF(2.58MB)

  37

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  184

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• Open Access Original Research

  Huaier Regulates Oxaliplatin Resistance in Colorectal Cancer by Regulating Autophagy and Inhibiting the Wnt/$\beta$-catenin Signalling Pathway

  Qi Feng, Mingyi Huo, Xiaoli Yan, Luwen Wen, Jining Zheng

  Front. Biosci. (Landmark Ed) 2024, 29(1), 15; https://doi.org/10.31083/j.fbl2901015

  Abstract Full Text PDF(3.94MB)

  43

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  147

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• Open Access Original Research

  DDX60 Promotes Migration and Invasion of Head and Neck Squamous Cell Carcinoma Cell through the NF-$\kappa$B/IFI27 Signaling Pathway

  Yumei Han, Jinbo Gao, Lei Liu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 14; https://doi.org/10.31083/j.fbl2901014

  Abstract Full Text PDF(9.41MB)

  30

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  115

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• Open Access Original Research

  Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival

  Xiao-Qiong Chen, Ke Lian, Zi-Wei Chen, Xuan Zhang, ... Yun-Feng Li

  Front. Biosci. (Landmark Ed) 2024, 29(1), 13; https://doi.org/10.31083/j.fbl2901013

  (This article belongs to the Special Issue Multi-Omics Biomarker Signatures in Precision Cancer Medicine)

  Abstract Full Text PDF(6.93MB)

  28

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  135

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• Open Access Systematic Review

  Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review

  Cristina Villa, Elisa Pellencin, Aurora Romeo, Giorgio Giaccone, ... Paola Caroppo

  Front. Biosci. (Landmark Ed) 2024, 29(1), 12; https://doi.org/10.31083/j.fbl2901012

  Abstract Full Text PDF(816.68KB)

  51

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  182

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• Open Access Original Research

  Differential Protection of Chickens against Highly Pathogenic H5 Avian Influenza Virus Using Polybasic Amino Acids with H5 Cleavage Peptide

  Sang Heui Seo

  Front. Biosci. (Landmark Ed) 2024, 29(1), 11; https://doi.org/10.31083/j.fbl2901011

  Abstract Full Text PDF(601.46KB)

  53

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  104

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• Open Access Original Research

  Seasonal Influence on Salivary Myeloperoxidase Diurnal Variations in Young Healthy Subjects: A Preliminary Study

  Kacper Nijakowski, Rafał Rutkowski, Dawid Gruszczyński, Janusz Witowski, ... Dominika Kanikowska

  Front. Biosci. (Landmark Ed) 2024, 29(1), 10; https://doi.org/10.31083/j.fbl2901010

  Abstract Full Text PDF(693.62KB)

  27

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  142

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• Open Access Original Research

  Association of 10 Genetic Variations and 10 Environmental Factors with Myopia of Different Severities in Different Age Groups of People in Northeast China

  Yan Sun, Zhuang Li, Zhuoshi Wang, Xingru He, ... Wei He

  Front. Biosci. (Landmark Ed) 2024, 29(1), 9; https://doi.org/10.31083/j.fbl2901009

  Abstract Full Text PDF(274.72KB)

  47

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  139

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• Open Access Review

  Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147

  Nada J. Habeichi, Ghadir Amin, Bachir Lakkis, Rayane Kataya, ... Fouad A. Zouein

  Front. Biosci. (Landmark Ed) 2024, 29(1), 8; https://doi.org/10.31083/j.fbl2901008

  Abstract Full Text PDF(3.02MB)

  57

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  227

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• Open Access Review

  Application of Genomic Data in Translational Medicine During the Big Data Era

  Yun Zhang, Jian Yu, Xiaoyan Xie, Feng Jiang, Chuyan Wu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 7; https://doi.org/10.31083/j.fbl2901007

  Abstract Full Text PDF(1.43MB)

  98

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  225

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• Open Access Original Research

  ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling

  Xiaoqing Chen, Jing Zhu, Xiangzhi Li, Jintao Chen, ... Dajiang Zhu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 6; https://doi.org/10.31083/j.fbl2901006

  Abstract Full Text PDF(2.76MB)

  47

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  177

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• Open Access Original Research

  SIRT6 Reduces Rheumatoid Arthritis Injury by Inhibiting MyD88-ERK Signaling Pathway

  Xiaolong Yu, Zihan Jin, Faisal Raza, Ping Zhang, ... Jing Xi

  Front. Biosci. (Landmark Ed) 2024, 29(1), 5; https://doi.org/10.31083/j.fbl2901005

  Abstract Full Text PDF(8.27MB)

  40

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  139

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• Open Access Original Research

  Parkinson's Disease Diagnosis Using miRNA Biomarkers and Deep Learning

  Alex Kumar, Valentina L. Kouznetsova, Santosh Kesari, Igor F. Tsigelny

  Front. Biosci. (Landmark Ed) 2024, 29(1), 4; https://doi.org/10.31083/j.fbl2901004

  Abstract Full Text PDF(7.27MB)

  62

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  180

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• Open Access Original Research

  Protein Signatures for Distinguishing Colorectal Cancer Liver Metastases from Primary Liver Cancer Using Tissue Slide Proteomics

  Xiaoman Zhou, Xiuyuan Wang, Ruizhen Bai, Hanjie Li, ... Quan Liu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 3; https://doi.org/10.31083/j.fbl2901003

  Abstract Full Text PDF(15.45MB)

  50

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  151

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• Open Access Original Research

  Optical Genome Mapping Reveals the Landscape of Structural Variations and Their Clinical Significance in HBOC-Related Breast Cancer

  Yanan Cheng, Li Dong, Dechao Bu, Lei Han, ... Jinpu Yu

  Front. Biosci. (Landmark Ed) 2024, 29(1), 2; https://doi.org/10.31083/j.fbl2901002

  Abstract Full Text PDF(8.18MB)

  65

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  190

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• Open Access Original Research

  Genome-Wide Identification of R2R3-MYB Family Genes and Their Response to Stress in Dendrobium nobile

  Liping Wu, Jizhou Fan, Xinglong Su, Daiyin Peng, Shihai Xing

  Front. Biosci. (Landmark Ed) 2024, 29(1), 1; https://doi.org/10.31083/j.fbl2901001

  Abstract Full Text PDF(11.91MB)

  29

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  103

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