- Academic Editor
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Background: To investigate the association of 10 genetic variations and
10 environmental factors with myopia of different severities in different age
groups of children and adolescents in northeast China. Methods: Parental
history and genetic testing for myopia-related susceptibility genes were carried
out in a cohort of children and adolescents aged 2–17 years. In addition, 10
single nucleotide polymorphism (SNP) sites for genotyping and 10 environmental
risk factors were selected, and the differences between site variation and
environmental factors in different age groups with different degrees of myopia
were explored. Results: A total of 2497 volunteers were recruited,
including 2023 myopes and 474 non-myopes in the control group. From the cohort,
1160 subjects were sequenced for myopia SNP sites. Compared with the non-myopic
group, the myopia of parents, outdoor activity less than 60 min per day, and a
high-sugar diet were risk factors for developing myopia. Two syntrophin beta 1
(SNTB1) sites, rs4455882 and rs6469937 were found to be significantly
associated with moderate myopia; fibroblast growth factor 10 (FGF10)
rs339501 was significantly correlated with high myopia; and insulin-like growth
factor 1 (IGF1) rs5742714 was significantly correlated with different
degrees of myopia in the age group of