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- Academic Editor
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†These authors contributed equally.
Background: Ferroptosis, an iron-dependent form of cell death, plays a crucial
role in the progression of various cancers, including colon adenocarcinoma
(COAD). However, the multi-omics signatures relevant to ferroptosis regulation in
COAD diagnosis remain to be elucidated. Methods: The transcriptomic, miRNAomic,
and methylomic profiles of COAD patients were acquired from the Cancer Genome
Atlas (TCGA). Ferroptosis activity in these patients was determined, represented
by a ferroptosis score (FS), using single-sample gene set enrichment analysis
(ssGSEA) based on the expression of ferroptosis-related genes. Results: Results
showed that the COAD patients with high-FS displayed favorable survival outcomes
and heightened drug sensitivity. They also exhibited an up-regulation of genes
involved in immune-related pathways (e.g., tumor necrosis factor signaling
pathway), suggesting a correlation between immunity and ferroptosis in COAD
progression. Furthermore, three survival prediction models were established based
on 10 CpGs, 12 long non-coding RNAs (lncRNAs), and 14 microRNAs (miRNAs),
respectively. These models demonstrated high accuracy in predicting COAD
survival, achieving areas under the curve (AUC)