†These authors contributed equally.
This is an open access article under the CC BY 4.0 license.
Background: Rheumatoid arthritis (RA) is an autoimmune disease
characterized by destruction of synovial joints, abnormal immune responses and
chronic inflammatory manifestations, which seriously affects patients’
well-being. We explored this study to ascertain the effect and mechanism
of silent information regulator 6 (SIRT6) on RA. Methods: Genes of RA
patients and normal volunteers were analyzed using Gene Expression Omnibus (GEO),
Kyoto-Encyclopedia of Genes and Genomes (KEGG) and Disconet databases. Serum
samples of RA patients and normal subjects were collected before detection of
myeloid differentiation factor-88 (MyD88)-extracellular signal-regulated kinase
(ERK) pathway proteins expression with Western blot. In vitro RA
fibroblast-like synoviocytes (FLS) cell model (RA-FLS) was established by
treating RSC-364 with recombinant rat IL-1