IMR Press / FBL / Volume 29 / Issue 1 / DOI: 10.31083/j.fbl2901026
Open Access Review
The Regulatory Role and Mechanism of Energy Metabolism in Vascular Diseases
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1 Key Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, 410208 Changsha, Hunan, China
2 Laboratory of Vascular Biology and translational medicine, School of Medicine, Hunan University of Chinese Medicine, 410208 Changsha, Hunan, China
3 Department of Science and Education, The first Hospital of Hunan University of Chinese Medicine, 410007 Changsha, Hunan, China
*Correspondence: (Qinhui Tuo)
Front. Biosci. (Landmark Ed) 2024, 29(1), 26;
Submitted: 26 August 2023 | Revised: 18 October 2023 | Accepted: 20 November 2023 | Published: 18 January 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Vascular diseases are amongst the most serious diseases affecting human life and health globally. Energy metabolism plays a crucial role in multiple vascular diseases, and the imbalance of energy metabolism in cells from the blood vessel wall can cause various vascular diseases. Energy metabolism studies have often focused on atherosclerosis (AS) and pulmonary hypertension (PH). However, the roles of energy metabolism in the development of other vascular diseases is becoming increasingly appreciated as both dynamic and essential. This review summarizes the role of energy metabolism in various vascular diseases, including AS, hemangioma, aortic dissection, PH, vascular aging, and arterial embolism. It also discusses how energy metabolism participates in the pathophysiological processes of vascular diseases and potential drugs that may interfere with energy metabolism. This review presents suggestions for the clinical prevention and treatment of vascular diseases from the perspective of energy metabolism.

aortic dissection
pulmonary hypertension
2022SK2011/Key Research and Development Projects of Hunan Provincial Science and Technology Department
2021RC4064/Science and Technology Innovation team of Hunan Province
20A379/Key Projects of Hunan Provincial Department of Education
2022CX15/Graduate Innovation Project of Hunan University of Chinese Medicine
S202310541108/2023 Undergraduate Innovation and Entrepreneurship Training Program of Hunan University of Chinese Medicine
Fig. 1.
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