Journal of Integrative Neuroscience

P-ISSN: 0219-6352

E-ISSN: 1757-448X

Journal of Integrative Neuroscience (JIN) is an international peer-reviewed, open access journal. The journal is devoted to publishing cutting-edge research in all areas of neuroscience, and welcomes research contributions on molecular, cellular, systems or translational neuroscience using a range of approaches and strategies. JIN aims to provide a platform for neuroscientists, neurologists, neurobiologists, and related researchers to share emerging knowledge and foster innovation within the scientific community. The journal accepts Original Research Articles, Reviews, Systematic Reviews, Short Communications, Editorials, Opinions, Letters to the Editor and Commentary Articles.

5 Days

Time to First Decision

42 Days

Review Time

87 Days

Submission to Acceptance

P-ISSN: 0219-6352

E-ISSN: 1757-448X

5 Days

Time to First Decision

42 Days

Review Time

87 Days

Submission to Acceptance

Highlights

JIN CiteScore Increased to 5

Acknowledgment to Reviewers of Journal of Integrative Neuroscience in 2025

We are Excited to Announce the Launch of Our New Website!

JIN Achieves Impact Factor 2.7 and JCR Q3 in 2024!

Advances in Spinal Cord Injury – Insights from AIM-SCI 2025

IMR Press Incorporates STM Integrity Hub into its Manuscript Review Process

Call for Early Career Researcher (ECR) Editorial Board Members - Join Now!

IMR Press becomes Member of STM

JIN is Now a Member of Committee on Publication Ethics (COPE)

Image Integrity Review Tool in IMR Press

JIN CiteScore Increased to 5

Acknowledgment to Reviewers of Journal of Integrative Neuroscience in 2025

We are Excited to Announce the Launch of Our New Website!

JIN Achieves Impact Factor 2.7 and JCR Q3 in 2024!

Advances in Spinal Cord Injury – Insights from AIM-SCI 2025

IMR Press Incorporates STM Integrity Hub into its Manuscript Review Process

Call for Early Career Researcher (ECR) Editorial Board Members - Join Now!

IMR Press becomes Member of STM

JIN is Now a Member of Committee on Publication Ethics (COPE)

Image Integrity Review Tool in IMR Press

Articles

View All

Latest Articles

Most Read

Funding

Functional Diversity of Mouse dLGN Neurons and Modulation of Their Encoding Properties by Superior Colliculus

Open Access 16 Jun 2026Original Research

Functional Diversity of Mouse dLGN Neurons and Modulation of Their Encoding Properties by Superior Colliculus

Xiaoying Ma, Chengyong Jiang, Wenbin Xie, Weilong Li, Qingyuan Chen, Yiheng Wang, Yuqing Chen, Junwen Luo, Su Jiang, Jiayi Zhang, Biao Yan

J. Integr. Neurosci. 2026, 25(6), 52032; https://doi.org/10.31083/JIN52032 (registering DOI)

Abstract

Download

Antiseizure Medications Impact Mitochondrial Ion Channels via Novel Bioenergetic and Neural Mechanisms

Open Access 16 Jun 2026Review

Antiseizure Medications Impact Mitochondrial Ion Channels via Novel Bioenergetic and Neural Mechanisms

Carmen Rubio, Norma Serrano-Garcia, Ricardo Pérez-Rubio, Javier Pérez-Villavicencio, Héctor Romo-Parra, Ángel Lee, Moisés Rubio-Osornio

J. Integr. Neurosci. 2026, 25(6), 52316; https://doi.org/10.31083/JIN52316 (registering DOI)

Abstract

Download

Efficacy and Safety of Transcranial Direct Current Stimulation on Multiple Health Outcomes in Neurological Disorders: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

Open Access 15 Jun 2026Systematic Review

Efficacy and Safety of Transcranial Direct Current Stimulation on Multiple Health Outcomes in Neurological Disorders: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

Tianfeng Ye, Yuli Shuai, Yiwei Liu, Sibei Liu, Xinyu Tang, Wei Tian, Yujia Zhang, Yuhan Kong

J. Integr. Neurosci. 2026, 25(6), 47145; https://doi.org/10.31083/JIN47145 (registering DOI)

Abstract

Download

Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain

Open Access 15 Jun 2026Review

Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain

Jiaxing Zhu, Haihua Xie, Yingke Ouyang, Ting Zhu, Qianyan Liu, Weiai Liu, Shulin Xiong, Mi Liu

J. Integr. Neurosci. 2026, 25(6), 48660; https://doi.org/10.31083/JIN48660 (registering DOI)

Abstract

Download

Assessing Cumulative Mental Fatigue via EEG-Based Machine Learning in a Multiday High-Intensity Contest

Open Access 15 Jun 2026Original Research

Assessing Cumulative Mental Fatigue via EEG-Based Machine Learning in a Multiday High-Intensity Contest

Xiaodong Yang, Jie Zhou, Zhan Chen, Yufei Jing, Yawei Xie, Hao Yu, Yongjie Yao, Chunpeng Jiang, Chuantao Li

J. Integr. Neurosci. 2026, 25(6), 49347; https://doi.org/10.31083/JIN49347 (registering DOI)

Abstract

Download

Long-Term Effects of Early Postnatal Administration of R-Baclofen on Neuronal Properties in the Cntnap2 Knockout Rat

Open Access 12 Jun 2026Original Research

Long-Term Effects of Early Postnatal Administration of R-Baclofen on Neuronal Properties in the Cntnap2 Knockout Rat

Hannah Pineda, Susanne Schmid

J. Integr. Neurosci. 2026, 25(6), 52072; https://doi.org/10.31083/JIN52072 (registering DOI)

Abstract

Download

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury

Open Access 26 May 2026Original Research

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury

Canwen Liu, Xuanyi Dong, Biao Tang

J. Integr. Neurosci. 2026, 25(5), 48011; https://doi.org/10.31083/JIN48011

Abstract

Download

224

“See What I Mean?” Linguistic Digital Markers of Cognitive Decline in Nursing Home Residents

Open Access 26 May 2026Original Research

“See What I Mean?” Linguistic Digital Markers of Cognitive Decline in Nursing Home Residents

Sonja Cecchetti, Andrew T. Duchowski, Marco Cavallo

J. Integr. Neurosci. 2026, 25(5), 49652; https://doi.org/10.31083/JIN49652

Abstract

Download

222

STING Mediates Necroptosis in Hippocampal Neurons of Mice With Sepsis-Associated Encephalopathy

Open Access 26 May 2026Original Research

STING Mediates Necroptosis in Hippocampal Neurons of Mice With Sepsis-Associated Encephalopathy

Xiaofeng Guo, Baocheng Cang, Yunhu Bai, Ding Zhang, You Wu, Tongwen Sun, Xijing Zhang

J. Integr. Neurosci. 2026, 25(5), 50074; https://doi.org/10.31083/JIN50074

Abstract

Download

161

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Open Access 25 May 2026Review

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Yuxuan Wang, Lingzhen Tan, Lin Lao, Xiaomeng Huang, Sheng Zhang, Haitao Sun

J. Integr. Neurosci. 2026, 25(5), 43257; https://doi.org/10.31083/JIN43257

Abstract

Download

229

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Open Access 25 May 2026Original Research

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Daniela Sýkorová, Barbora Kolářová, Petr Kolář, David Krahulík, Ahmed Naser Mohamed Afifi, Pavel Otruba, Martin Nevrlý

J. Integr. Neurosci. 2026, 25(5), 48076; https://doi.org/10.31083/JIN48076

Abstract

Download

185

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Open Access 25 May 2026Review

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Wojciech Owecki, Anna Futyma, Olga Kokorniak, Aleksandra Szczech, Bartosz Słowikowski, Joanna Poszwa, Oliwia Szymanowicz, Ulyana Goutor, Paweł P. Jagodziński, Wojciech Kozubski, Jolanta Dorszewska

J. Integr. Neurosci. 2026, 25(5), 50055; https://doi.org/10.31083/JIN50055

Abstract

Download

221

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Open Access 19 May 2026Review

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Ying Li, Pengwei Zhuang

J. Integr. Neurosci. 2026, 25(5), 45956; https://doi.org/10.31083/JIN45956

Abstract

Download

226

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Open Access 19 May 2026Original Research

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Yu Kong, Xinhuang Lv, Yao Yang, Qiyao Li, Conghui Dai, Xiaoou Lin, Jiaming Liu, Jing Li

J. Integr. Neurosci. 2026, 25(5), 48598; https://doi.org/10.31083/JIN48598

Abstract

Download

193

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Open Access 19 May 2026Opinion

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Parisa Gazerani

J. Integr. Neurosci. 2026, 25(5), 50563; https://doi.org/10.31083/JIN50563

(This article belongs to the Special Issue Advancing Neurological Care with AI and Digital Twins)

Abstract

Download

240

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Open Access 12 May 2026Original Research

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Zhiyong Xu, Yan Liu, Yan Yu

J. Integr. Neurosci. 2026, 25(5), 49065; https://doi.org/10.31083/JIN49065

Abstract

Download

243

Latest Articles

Most Read

Funding

Functional Diversity of Mouse dLGN Neurons and Modulation of Their Encoding Properties by Superior Colliculus

Open Access 16 Jun 2026Original Research

Functional Diversity of Mouse dLGN Neurons and Modulation of Their Encoding Properties by Superior Colliculus

Xiaoying Ma, Chengyong Jiang, Wenbin Xie, Weilong Li, Qingyuan Chen, Yiheng Wang, Yuqing Chen, Junwen Luo, Su Jiang, Jiayi Zhang, Biao Yan

J. Integr. Neurosci. 2026, 25(6), 52032; https://doi.org/10.31083/JIN52032 (registering DOI)

Abstract

Download

Antiseizure Medications Impact Mitochondrial Ion Channels via Novel Bioenergetic and Neural Mechanisms

Open Access 16 Jun 2026Review

Antiseizure Medications Impact Mitochondrial Ion Channels via Novel Bioenergetic and Neural Mechanisms

Carmen Rubio, Norma Serrano-Garcia, Ricardo Pérez-Rubio, Javier Pérez-Villavicencio, Héctor Romo-Parra, Ángel Lee, Moisés Rubio-Osornio

J. Integr. Neurosci. 2026, 25(6), 52316; https://doi.org/10.31083/JIN52316 (registering DOI)

Abstract

Download

Efficacy and Safety of Transcranial Direct Current Stimulation on Multiple Health Outcomes in Neurological Disorders: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

Open Access 15 Jun 2026Systematic Review

Efficacy and Safety of Transcranial Direct Current Stimulation on Multiple Health Outcomes in Neurological Disorders: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

Tianfeng Ye, Yuli Shuai, Yiwei Liu, Sibei Liu, Xinyu Tang, Wei Tian, Yujia Zhang, Yuhan Kong

J. Integr. Neurosci. 2026, 25(6), 47145; https://doi.org/10.31083/JIN47145 (registering DOI)

Abstract

Download

Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain

Open Access 15 Jun 2026Review

Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain

Jiaxing Zhu, Haihua Xie, Yingke Ouyang, Ting Zhu, Qianyan Liu, Weiai Liu, Shulin Xiong, Mi Liu

J. Integr. Neurosci. 2026, 25(6), 48660; https://doi.org/10.31083/JIN48660 (registering DOI)

Abstract

Download

Assessing Cumulative Mental Fatigue via EEG-Based Machine Learning in a Multiday High-Intensity Contest

Open Access 15 Jun 2026Original Research

Assessing Cumulative Mental Fatigue via EEG-Based Machine Learning in a Multiday High-Intensity Contest

Xiaodong Yang, Jie Zhou, Zhan Chen, Yufei Jing, Yawei Xie, Hao Yu, Yongjie Yao, Chunpeng Jiang, Chuantao Li

J. Integr. Neurosci. 2026, 25(6), 49347; https://doi.org/10.31083/JIN49347 (registering DOI)

Abstract

Download

Long-Term Effects of Early Postnatal Administration of R-Baclofen on Neuronal Properties in the Cntnap2 Knockout Rat

Open Access 12 Jun 2026Original Research

Long-Term Effects of Early Postnatal Administration of R-Baclofen on Neuronal Properties in the Cntnap2 Knockout Rat

Hannah Pineda, Susanne Schmid

J. Integr. Neurosci. 2026, 25(6), 52072; https://doi.org/10.31083/JIN52072 (registering DOI)

Abstract

Download

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury

Open Access 26 May 2026Original Research

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury

Canwen Liu, Xuanyi Dong, Biao Tang

J. Integr. Neurosci. 2026, 25(5), 48011; https://doi.org/10.31083/JIN48011

Abstract

Download

224

“See What I Mean?” Linguistic Digital Markers of Cognitive Decline in Nursing Home Residents

Open Access 26 May 2026Original Research

“See What I Mean?” Linguistic Digital Markers of Cognitive Decline in Nursing Home Residents

Sonja Cecchetti, Andrew T. Duchowski, Marco Cavallo

J. Integr. Neurosci. 2026, 25(5), 49652; https://doi.org/10.31083/JIN49652

Abstract

Download

222

STING Mediates Necroptosis in Hippocampal Neurons of Mice With Sepsis-Associated Encephalopathy

Open Access 26 May 2026Original Research

STING Mediates Necroptosis in Hippocampal Neurons of Mice With Sepsis-Associated Encephalopathy

Xiaofeng Guo, Baocheng Cang, Yunhu Bai, Ding Zhang, You Wu, Tongwen Sun, Xijing Zhang

J. Integr. Neurosci. 2026, 25(5), 50074; https://doi.org/10.31083/JIN50074

Abstract

Download

161

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Open Access 25 May 2026Review

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Yuxuan Wang, Lingzhen Tan, Lin Lao, Xiaomeng Huang, Sheng Zhang, Haitao Sun

J. Integr. Neurosci. 2026, 25(5), 43257; https://doi.org/10.31083/JIN43257

Abstract

Download

229

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Open Access 25 May 2026Original Research

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Daniela Sýkorová, Barbora Kolářová, Petr Kolář, David Krahulík, Ahmed Naser Mohamed Afifi, Pavel Otruba, Martin Nevrlý

J. Integr. Neurosci. 2026, 25(5), 48076; https://doi.org/10.31083/JIN48076

Abstract

Download

185

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Open Access 25 May 2026Review

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Wojciech Owecki, Anna Futyma, Olga Kokorniak, Aleksandra Szczech, Bartosz Słowikowski, Joanna Poszwa, Oliwia Szymanowicz, Ulyana Goutor, Paweł P. Jagodziński, Wojciech Kozubski, Jolanta Dorszewska

J. Integr. Neurosci. 2026, 25(5), 50055; https://doi.org/10.31083/JIN50055

Abstract

Download

221

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Open Access 19 May 2026Review

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Ying Li, Pengwei Zhuang

J. Integr. Neurosci. 2026, 25(5), 45956; https://doi.org/10.31083/JIN45956

Abstract

Download

226

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Open Access 19 May 2026Original Research

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Yu Kong, Xinhuang Lv, Yao Yang, Qiyao Li, Conghui Dai, Xiaoou Lin, Jiaming Liu, Jing Li

J. Integr. Neurosci. 2026, 25(5), 48598; https://doi.org/10.31083/JIN48598

Abstract

Download

193

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Open Access 19 May 2026Opinion

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Parisa Gazerani

J. Integr. Neurosci. 2026, 25(5), 50563; https://doi.org/10.31083/JIN50563

(This article belongs to the Special Issue Advancing Neurological Care with AI and Digital Twins)

Abstract

Download

240

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Open Access 12 May 2026Original Research

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Zhiyong Xu, Yan Liu, Yan Yu

J. Integr. Neurosci. 2026, 25(5), 49065; https://doi.org/10.31083/JIN49065

Abstract

Download

243

View All

Announcements

View All

Announcements

View All

Journal Metrics

Metrics

Impact Factor2.7

CiteScore5

Frequency12 issues per year

Establish Year2002

Indexing

SCIE (Web of Science), MEDLINE (PubMed), Scopus, DOAJ

Journal Metrics

Metrics

Impact Factor2.7

CiteScore5

Frequency12 issues per year

Establish Year2002

Indexing

SCIE (Web of Science), MEDLINE (PubMed), Scopus, DOAJ

Email Alert

Add your e-mail address to receive forthcoming issues of this journal:

Email Alert

Add your e-mail address to receive forthcoming issues of this journal:

Interviews

Special Interview with Francesco Ruggeri: Exploring Retinal Optical Coherence Tomography (OCT) Biomarkers for Neurodegenerative Diseases

Special Interview with Editorial Board Member Dr. Nuno A. Silva: Exploration of New Treatments and Collaborative Paths for Spinal Cord Injury

Interviews

Special Interview with Francesco Ruggeri: Exploring Retinal Optical Coherence Tomography (OCT) Biomarkers for Neurodegenerative Diseases

Special Interview with Editorial Board Member Dr. Nuno A. Silva: Exploration of New Treatments and Collaborative Paths for Spinal Cord Injury

Editorial Board

View All

Zhong Chen
Editor-in-Chief
brain disorders; epilepsy; stroke; neuropathic pain; histaminergic neurons; histaminergic receptors
Bettina Platt
Editor-in-Chief
brain health; neurodegeneration; dementia; cognition; senescence; translational technologies; EEG; stem cells; inflammation; therapeutics

Editorial Board

Zhong Chen
Editor-in-Chief
brain disorders; epilepsy; stroke; neuropathic pain; histaminergic neurons; histaminergic receptors
Bettina Platt
Editor-in-Chief
brain health; neurodegeneration; dementia; cognition; senescence; translational technologies; EEG; stem cells; inflammation; therapeutics

View All

Special Issues

View All

Special Issues

View All

Featured Visual Abstracts

The Role of Artificial Intelligence in Diagnosing Acute Ischemic Stroke Using Diffusion MRI: A Multicenter External Validation Study — Graphical Abstract

Pathophysiological Divergence Between Vascular and Post-Stroke Dementia: Bridging Human and Experimental Perspectives—Graphical Abstract

Pure-Tone Frequency Discrimination and Auditory Functional Connectivity in Developmental Dyslexia—Graphical Abstract

Graphic Abstract: Morphological Alterations in Schizophrenia—An Interdisciplinary Review

Neural Correlates of Social Touch Processing: An fMRI Study on Brain Functional Connectivity—Graphic Abstract

Featured Visual Abstracts

The Role of Artificial Intelligence in Diagnosing Acute Ischemic Stroke Using Diffusion MRI: A Multicenter External Validation Study — Graphical Abstract

Pathophysiological Divergence Between Vascular and Post-Stroke Dementia: Bridging Human and Experimental Perspectives—Graphical Abstract

Pure-Tone Frequency Discrimination and Auditory Functional Connectivity in Developmental Dyslexia—Graphical Abstract

Graphic Abstract: Morphological Alterations in Schizophrenia—An Interdisciplinary Review

Neural Correlates of Social Touch Processing: An fMRI Study on Brain Functional Connectivity—Graphic Abstract

Conferences

View All

Conferences

View All

Membership