Volume 25, Issue 1 (January 2026)

Rocío Valle-Bautista, Itzamara Soto-Villanueva, Dafne A. Díaz-Piña, Vivian A. Chávez Pérez, Evelin V. Idiaquez-Hernández, Daniela Ávila-González, Néstor Fabián Díaz, Anayansi Molina-Hernández

J. Integr. Neurosci. 2026, 25(1), 46827; https://doi.org/10.31083/JIN46827

Abstract

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462

Association of Functional and White Matter Structural Brain Network in Older Cerebral Small Vessel Disease With Cognitive Impairment

Open Access 23 Jan 2026Original Research

Association of Functional and White Matter Structural Brain Network in Older Cerebral Small Vessel Disease With Cognitive Impairment

Yumeng Gu, Jing Zhao, Wenjun Feng, Chao Wang, Yu Yan, Xiaowen Wang, Xin Li

J. Integr. Neurosci. 2026, 25(1), 47508; https://doi.org/10.31083/JIN47508

Abstract

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325

Adipose-Derived Stem Cells Transfected to Express Brain-Derived Neurotrophic Factor Reduce Hippocampal Amyloid Plaque Load and Improve Dendritic Morphology in the APP/PS1dE9 Mouse Model of Alzheimer’s Disease

Open Access 23 Jan 2026Original Research

Yuzhen Luo, Yiheng Liu, Hui Long, Caini Pei, Lujia Mao, Gregory M. Rose, Haiying Zhang

J. Integr. Neurosci. 2026, 25(1), 46077; https://doi.org/10.31083/JIN46077

Abstract

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350

EEG in Insomnia Disorder: Novel Findings and Future Directions

Open Access 23 Jan 2026Opinion

EEG in Insomnia Disorder: Novel Findings and Future Directions

Maurizio Gorgoni, Valentina Alfonsi, Luigi De Gennaro

J. Integr. Neurosci. 2026, 25(1), 46749; https://doi.org/10.31083/JIN46749

Abstract

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616

Lutein Attenuates Parkinson’s Disease Progression by Regulating Mitochondrial Function via the TRIM31/Drp1 Signaling Pathway

Open Access 23 Jan 2026Original Research

Lutein Attenuates Parkinson’s Disease Progression by Regulating Mitochondrial Function via the TRIM31/Drp1 Signaling Pathway

Jiabin Duan, Wenbin Duan, Xiaomin Pu, Changdi Ma, Huai Huang, Zhenghu Xu

J. Integr. Neurosci. 2026, 25(1), 45758; https://doi.org/10.31083/JIN45758

Abstract

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435

Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4

Open Access 23 Jan 2026Original Research

Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4

Jiahong Zhong, Xihui Yu, Junling Xue, Qiuming Wang, Zhuomiao Lin

J. Integr. Neurosci. 2026, 25(1), 45490; https://doi.org/10.31083/JIN45490

Abstract

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394

Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats

Open Access 22 Jan 2026Original Research

Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats

Bowen Chen, Rong Hu, Xingying Wu, Mengting Shi, Yi Chen, Jieqi Zhang, Yi Huang, Xihan Ying, Dexiong Han, Ruijie Ma

J. Integr. Neurosci. 2026, 25(1), 46448; https://doi.org/10.31083/JIN46448

Abstract

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389

The Icelandic Mutation in the Murine APP Gene, mAPP^A673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model

Open Access 22 Jan 2026Original Research

The Icelandic Mutation in the Murine APP Gene, mAPP^A673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model

Anne Anschuetz, Renny Listyono, Thomas Vorley, Bettina Platt, Charles R. Harrington, Gernot Riedel, Karima Schwab

J. Integr. Neurosci. 2026, 25(1), 48581; https://doi.org/10.31083/JIN48581

(This article belongs to the Special Issue Scottish Neuroscience-2026)

Abstract

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444

Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis

Open Access 21 Jan 2026Original Research

Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis

Lihui Wang, Yijiao Long, Fei Wang, Jincheng Guo, Lin Li, Baohua Hou

J. Integr. Neurosci. 2026, 25(1), 47186; https://doi.org/10.31083/JIN47186

Abstract

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394

Altered Neural Activity and Functional Connectivity of Dorsolateral Prefrontal Cortex Associated With Cognitive Impairment in Patients With End-Stage Renal Disease

Open Access 21 Jan 2026Original Research

Altered Neural Activity and Functional Connectivity of Dorsolateral Prefrontal Cortex Associated With Cognitive Impairment in Patients With End-Stage Renal Disease

Jie Fang, Lingling Guo, Hongting Xu, Yu Zhou, Fan Zou, Jinmin Wu, Yuping Wang, Xiangming Qi, Haibao Wang

J. Integr. Neurosci. 2026, 25(1), 46820; https://doi.org/10.31083/JIN46820

Abstract

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259

Exercise Suppresses Insulin Resistance: A Potential Mechanism for Improving the Interaction Between Type 2 Diabetes and Alzheimer’s Disease

Open Access 21 Jan 2026Review

Exercise Suppresses Insulin Resistance: A Potential Mechanism for Improving the Interaction Between Type 2 Diabetes and Alzheimer’s Disease

Bo Wang, Yuping Shao, Rongxiang Liang

J. Integr. Neurosci. 2026, 25(1), 44389; https://doi.org/10.31083/JIN44389

Abstract

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833

Glymphatic Clearance Dynamics in Traumatic Brain Injury: Mechanisms, Imaging Biomarkers, and Application Prospects

Open Access 9 Jan 2026Review

Glymphatic Clearance Dynamics in Traumatic Brain Injury: Mechanisms, Imaging Biomarkers, and Application Prospects

Tao Yang, Yongxiang Yang, Mu Yuan, Xin Chen, Jingmin Cheng, Kexia Fan, Yuan Ma, Haifeng Shu, Sixun Yu

J. Integr. Neurosci. 2026, 25(1), 44348; https://doi.org/10.31083/JIN44348

Abstract

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711

Overexpression of IL7R Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Apoptosis

Open Access 9 Jan 2026Original Research

Overexpression of IL7R Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Apoptosis

Shiqi Yang, Qian Su, Wenting Liu, Delong Meng, Zhiqiang Su

J. Integr. Neurosci. 2026, 25(1), 46638; https://doi.org/10.31083/JIN46638

Abstract

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446

Volume 25, Issue 1 (2026)

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Neuroplasticity and Alzheimer’s Disease

Open Access 26 Jan 2026Review

Neuroplasticity and Alzheimer’s Disease

Ashkan Asgari Gashtrodkhani, Samaneh Ghorbani Shirkouhi, Seyed Sepehr Khatami, Farzin Kamari, Sarvenaz Ghaedi, Morten Blaabjerg, Sasan Andalib

J. Integr. Neurosci. 2026, 25(1), 48051; https://doi.org/10.31083/JIN48051

Abstract

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1435

Multi-Scale Adaptive Temporal Network for Parkinson’s Motor Symptom Fluctuation Detection Using Coarsened 2D Skeleton Pose Data

Open Access 26 Jan 2026Original Research

Multi-Scale Adaptive Temporal Network for Parkinson’s Motor Symptom Fluctuation Detection Using Coarsened 2D Skeleton Pose Data

Balamurugan Velumani, Sivasankari Krishnakumar

J. Integr. Neurosci. 2026, 25(1), 47677; https://doi.org/10.31083/JIN47677

Abstract

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491

Effect of Physical Activity on Cognitive Function of Patients With Alzheimer’s Disease: A Meta-analysis

Open Access 26 Jan 2026Systematic Review

Effect of Physical Activity on Cognitive Function of Patients With Alzheimer’s Disease: A Meta-analysis

Shengyu Dai, Shunling Yuan, Xinbi Zhang, Xiaoke Zhong, Changhao Jiang

J. Integr. Neurosci. 2026, 25(1), 42702; https://doi.org/10.31083/JIN42702

Abstract

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645

Effect of Maternal Hyperglycemia on Cortical Neuronal Migration: Hypofunction of Reelin Signaling

Open Access 23 Jan 2026Original Research

Effect of Maternal Hyperglycemia on Cortical Neuronal Migration: Hypofunction of Reelin Signaling

J. Integr. Neurosci. 2026, 25(1), 46827; https://doi.org/10.31083/JIN46827

Abstract

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462

Association of Functional and White Matter Structural Brain Network in Older Cerebral Small Vessel Disease With Cognitive Impairment

Open Access 23 Jan 2026Original Research

Association of Functional and White Matter Structural Brain Network in Older Cerebral Small Vessel Disease With Cognitive Impairment

Yumeng Gu, Jing Zhao, Wenjun Feng, Chao Wang, Yu Yan, Xiaowen Wang, Xin Li

J. Integr. Neurosci. 2026, 25(1), 47508; https://doi.org/10.31083/JIN47508

Abstract

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325

Open Access 23 Jan 2026Original Research

Yuzhen Luo, Yiheng Liu, Hui Long, Caini Pei, Lujia Mao, Gregory M. Rose, Haiying Zhang

J. Integr. Neurosci. 2026, 25(1), 46077; https://doi.org/10.31083/JIN46077

Abstract

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350

EEG in Insomnia Disorder: Novel Findings and Future Directions

Open Access 23 Jan 2026Opinion

EEG in Insomnia Disorder: Novel Findings and Future Directions

Maurizio Gorgoni, Valentina Alfonsi, Luigi De Gennaro

J. Integr. Neurosci. 2026, 25(1), 46749; https://doi.org/10.31083/JIN46749

Abstract

Download

616

Lutein Attenuates Parkinson’s Disease Progression by Regulating Mitochondrial Function via the TRIM31/Drp1 Signaling Pathway

Open Access 23 Jan 2026Original Research

Lutein Attenuates Parkinson’s Disease Progression by Regulating Mitochondrial Function via the TRIM31/Drp1 Signaling Pathway

Jiabin Duan, Wenbin Duan, Xiaomin Pu, Changdi Ma, Huai Huang, Zhenghu Xu

J. Integr. Neurosci. 2026, 25(1), 45758; https://doi.org/10.31083/JIN45758

Abstract

Download

435

Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4

Open Access 23 Jan 2026Original Research

Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4

Jiahong Zhong, Xihui Yu, Junling Xue, Qiuming Wang, Zhuomiao Lin

J. Integr. Neurosci. 2026, 25(1), 45490; https://doi.org/10.31083/JIN45490

Abstract

Download

394

Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats

Open Access 22 Jan 2026Original Research

Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats

Bowen Chen, Rong Hu, Xingying Wu, Mengting Shi, Yi Chen, Jieqi Zhang, Yi Huang, Xihan Ying, Dexiong Han, Ruijie Ma

J. Integr. Neurosci. 2026, 25(1), 46448; https://doi.org/10.31083/JIN46448

Abstract

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389

The Icelandic Mutation in the Murine APP Gene, mAPP^A673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model

Open Access 22 Jan 2026Original Research

The Icelandic Mutation in the Murine APP Gene, mAPP^A673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model

Anne Anschuetz, Renny Listyono, Thomas Vorley, Bettina Platt, Charles R. Harrington, Gernot Riedel, Karima Schwab

J. Integr. Neurosci. 2026, 25(1), 48581; https://doi.org/10.31083/JIN48581

(This article belongs to the Special Issue Scottish Neuroscience-2026)

Abstract

Download

444

Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis

Open Access 21 Jan 2026Original Research

Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis

Lihui Wang, Yijiao Long, Fei Wang, Jincheng Guo, Lin Li, Baohua Hou

J. Integr. Neurosci. 2026, 25(1), 47186; https://doi.org/10.31083/JIN47186

Abstract

Download

394

Altered Neural Activity and Functional Connectivity of Dorsolateral Prefrontal Cortex Associated With Cognitive Impairment in Patients With End-Stage Renal Disease

Open Access 21 Jan 2026Original Research

Altered Neural Activity and Functional Connectivity of Dorsolateral Prefrontal Cortex Associated With Cognitive Impairment in Patients With End-Stage Renal Disease

Jie Fang, Lingling Guo, Hongting Xu, Yu Zhou, Fan Zou, Jinmin Wu, Yuping Wang, Xiangming Qi, Haibao Wang

J. Integr. Neurosci. 2026, 25(1), 46820; https://doi.org/10.31083/JIN46820

Abstract

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259

Exercise Suppresses Insulin Resistance: A Potential Mechanism for Improving the Interaction Between Type 2 Diabetes and Alzheimer’s Disease

Open Access 21 Jan 2026Review

Exercise Suppresses Insulin Resistance: A Potential Mechanism for Improving the Interaction Between Type 2 Diabetes and Alzheimer’s Disease

Bo Wang, Yuping Shao, Rongxiang Liang

J. Integr. Neurosci. 2026, 25(1), 44389; https://doi.org/10.31083/JIN44389

Abstract

Download

833

Glymphatic Clearance Dynamics in Traumatic Brain Injury: Mechanisms, Imaging Biomarkers, and Application Prospects

Open Access 9 Jan 2026Review

Glymphatic Clearance Dynamics in Traumatic Brain Injury: Mechanisms, Imaging Biomarkers, and Application Prospects

Tao Yang, Yongxiang Yang, Mu Yuan, Xin Chen, Jingmin Cheng, Kexia Fan, Yuan Ma, Haifeng Shu, Sixun Yu

J. Integr. Neurosci. 2026, 25(1), 44348; https://doi.org/10.31083/JIN44348

Abstract

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711

Overexpression of IL7R Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Apoptosis

Open Access 9 Jan 2026Original Research

Overexpression of IL7R Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Apoptosis

Shiqi Yang, Qian Su, Wenting Liu, Delong Meng, Zhiqiang Su

J. Integr. Neurosci. 2026, 25(1), 46638; https://doi.org/10.31083/JIN46638

Abstract

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446