Volume 25, Issue 5 (May 2026)

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Open Access 25 May 2026Review

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Wojciech Owecki, Anna Futyma, Olga Kokorniak, Aleksandra Szczech, Bartosz Słowikowski, Joanna Poszwa, Oliwia Szymanowicz, Ulyana Goutor, Paweł P. Jagodziński, Wojciech Kozubski, Jolanta Dorszewska

J. Integr. Neurosci. 2026, 25(5), 50055; https://doi.org/10.31083/JIN50055 (registering DOI)

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Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Open Access 25 May 2026Original Research

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Daniela Sýkorová, Barbora Kolářová, Petr Kolář, David Krahulík, Ahmed Naser Mohamed Afifi, Pavel Otruba, Martin Nevrlý

J. Integr. Neurosci. 2026, 25(5), 48076; https://doi.org/10.31083/JIN48076 (registering DOI)

Abstract

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Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Open Access 25 May 2026Review

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Yuxuan Wang, Lingzhen Tan, Lin Lao, Xiaomeng Huang, Sheng Zhang, Haitao Sun

J. Integr. Neurosci. 2026, 25(5), 43257; https://doi.org/10.31083/JIN43257 (registering DOI)

Abstract

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Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Open Access 19 May 2026Opinion

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Parisa Gazerani

J. Integr. Neurosci. 2026, 25(5), 50563; https://doi.org/10.31083/JIN50563 (registering DOI)

(This article belongs to the Special Issue Advancing Neurological Care with AI and Digital Twins)

Abstract

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Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Open Access 19 May 2026Original Research

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Yu Kong, Xinhuang Lv, Yao Yang, Qiyao Li, Conghui Dai, Xiaoou Lin, Jiaming Liu, Jing Li

J. Integr. Neurosci. 2026, 25(5), 48598; https://doi.org/10.31083/JIN48598 (registering DOI)

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Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Open Access 19 May 2026Review

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Ying Li, Pengwei Zhuang

J. Integr. Neurosci. 2026, 25(5), 45956; https://doi.org/10.31083/JIN45956 (registering DOI)

Abstract

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Usefulness of Non-Contrast Electron Density Imaging for the Identification of Brain Tissue Changes in Large Vessel Occlusion Acute Ischemic Stroke

Open Access 12 May 2026Short Communication

Usefulness of Non-Contrast Electron Density Imaging for the Identification of Brain Tissue Changes in Large Vessel Occlusion Acute Ischemic Stroke

Santiago de Erausquin, Andres Polania, Gaston A. Rodriguez-Granillo, Pablo Diluca, Carlos Bleise, Pedro Lylyk

J. Integr. Neurosci. 2026, 25(5), 50299; https://doi.org/10.31083/JIN50299 (registering DOI)

Abstract

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Single-Cell and Integrative Analyses Uncover Therapeutic Potential of RFX1-Mediated Cuproptosis in PitNETs

Open Access 12 May 2026Original Research

Single-Cell and Integrative Analyses Uncover Therapeutic Potential of RFX1-Mediated Cuproptosis in PitNETs

Shuangjian Yang, Changqin Pu, Congcong Deng, Xuexue Bai, Si Wu, Chenxin Tian, Xueyou Xu, Renzhi Wang, Mengqi Chang, Ming Feng

J. Integr. Neurosci. 2026, 25(5), 49669; https://doi.org/10.31083/JIN49669 (registering DOI)

Abstract

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Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Open Access 12 May 2026Original Research

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Zhiyong Xu, Yan Liu, Yan Yu

J. Integr. Neurosci. 2026, 25(5), 49065; https://doi.org/10.31083/JIN49065 (registering DOI)

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132

Understanding Sleep and Memory in the Avian Brain

Open Access 9 May 2026Review

Understanding Sleep and Memory in the Avian Brain

Janie M. Ondracek

J. Integr. Neurosci. 2026, 25(5), 50421; https://doi.org/10.31083/JIN50421 (registering DOI)

Abstract

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123

The Neuroprotective Role of a Caspase-1 Inhibitor Against Apoptosis via Inhibition of Glial Hyperactivation in a Mouse Model of Epilepsy

Open Access 9 May 2026Original Research

The Neuroprotective Role of a Caspase-1 Inhibitor Against Apoptosis via Inhibition of Glial Hyperactivation in a Mouse Model of Epilepsy

Hui Cai, Xinran Xu, Xuerui Zhuo, Zhe Liu, Hao Liu, Yiming Sun

J. Integr. Neurosci. 2026, 25(5), 49777; https://doi.org/10.31083/JIN49777 (registering DOI)

Abstract

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Longitudinal Reorganization of Local Brain Activity Following Acute Basal Ganglia Infarction: Combined Metrics of Amplitude and Dynamics Reveal Neural Substrates Underlying Motor Recovery

Open Access 9 May 2026Original Research

Longitudinal Reorganization of Local Brain Activity Following Acute Basal Ganglia Infarction: Combined Metrics of Amplitude and Dynamics Reveal Neural Substrates Underlying Motor Recovery

Shijian Chen, Jian Zhang, Yayuan Liu, Xuemei Quan, Qiong Yin, Liya Pan, Zhijian Liang

J. Integr. Neurosci. 2026, 25(5), 47725; https://doi.org/10.31083/JIN47725 (registering DOI)

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Metabolic Brain Network Reorganization in Temporal Lobe Epilepsy With Aware or Impaired Awareness Seizures

Open Access 9 May 2026Original Research

Metabolic Brain Network Reorganization in Temporal Lobe Epilepsy With Aware or Impaired Awareness Seizures

Jingke Xiao, Fan Yang, Hanlin Zhang, Jiangyan Liu

J. Integr. Neurosci. 2026, 25(5), 47320; https://doi.org/10.31083/JIN47320 (registering DOI)

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111

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Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Open Access 25 May 2026Review

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Wojciech Owecki, Anna Futyma, Olga Kokorniak, Aleksandra Szczech, Bartosz Słowikowski, Joanna Poszwa, Oliwia Szymanowicz, Ulyana Goutor, Paweł P. Jagodziński, Wojciech Kozubski, Jolanta Dorszewska

J. Integr. Neurosci. 2026, 25(5), 50055; https://doi.org/10.31083/JIN50055 (registering DOI)

Abstract

Download

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Open Access 25 May 2026Original Research

Influence of Gait Speed on Spatiotemporal Parameters in Advanced Parkinson’s Disease Following Subthalamic Nucleus Deep Brain Stimulation

Daniela Sýkorová, Barbora Kolářová, Petr Kolář, David Krahulík, Ahmed Naser Mohamed Afifi, Pavel Otruba, Martin Nevrlý

J. Integr. Neurosci. 2026, 25(5), 48076; https://doi.org/10.31083/JIN48076 (registering DOI)

Abstract

Download

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Open Access 25 May 2026Review

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Yuxuan Wang, Lingzhen Tan, Lin Lao, Xiaomeng Huang, Sheng Zhang, Haitao Sun

J. Integr. Neurosci. 2026, 25(5), 43257; https://doi.org/10.31083/JIN43257 (registering DOI)

Abstract

Download

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Open Access 19 May 2026Opinion

Digital Twins in Neurology Care: Evidence, Limitations, and a Path Forward

Parisa Gazerani

J. Integr. Neurosci. 2026, 25(5), 50563; https://doi.org/10.31083/JIN50563 (registering DOI)

(This article belongs to the Special Issue Advancing Neurological Care with AI and Digital Twins)

Abstract

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Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Open Access 19 May 2026Original Research

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Yu Kong, Xinhuang Lv, Yao Yang, Qiyao Li, Conghui Dai, Xiaoou Lin, Jiaming Liu, Jing Li

J. Integr. Neurosci. 2026, 25(5), 48598; https://doi.org/10.31083/JIN48598 (registering DOI)

Abstract

Download

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Open Access 19 May 2026Review

Research Progress on How Multimodal Signals Regulate Neuronal Mitochondrial Homeostasis to Affect Diabetic Cognitive Impairment

Ying Li, Pengwei Zhuang

J. Integr. Neurosci. 2026, 25(5), 45956; https://doi.org/10.31083/JIN45956 (registering DOI)

Abstract

Download

Usefulness of Non-Contrast Electron Density Imaging for the Identification of Brain Tissue Changes in Large Vessel Occlusion Acute Ischemic Stroke

Open Access 12 May 2026Short Communication

Usefulness of Non-Contrast Electron Density Imaging for the Identification of Brain Tissue Changes in Large Vessel Occlusion Acute Ischemic Stroke

Santiago de Erausquin, Andres Polania, Gaston A. Rodriguez-Granillo, Pablo Diluca, Carlos Bleise, Pedro Lylyk

J. Integr. Neurosci. 2026, 25(5), 50299; https://doi.org/10.31083/JIN50299 (registering DOI)

Abstract

Download

Single-Cell and Integrative Analyses Uncover Therapeutic Potential of RFX1-Mediated Cuproptosis in PitNETs

Open Access 12 May 2026Original Research

Single-Cell and Integrative Analyses Uncover Therapeutic Potential of RFX1-Mediated Cuproptosis in PitNETs

Shuangjian Yang, Changqin Pu, Congcong Deng, Xuexue Bai, Si Wu, Chenxin Tian, Xueyou Xu, Renzhi Wang, Mengqi Chang, Ming Feng

J. Integr. Neurosci. 2026, 25(5), 49669; https://doi.org/10.31083/JIN49669 (registering DOI)

Abstract

Download

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Open Access 12 May 2026Original Research

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Zhiyong Xu, Yan Liu, Yan Yu

J. Integr. Neurosci. 2026, 25(5), 49065; https://doi.org/10.31083/JIN49065 (registering DOI)

Abstract

Download

132

Understanding Sleep and Memory in the Avian Brain

Open Access 9 May 2026Review

Understanding Sleep and Memory in the Avian Brain

Janie M. Ondracek

J. Integr. Neurosci. 2026, 25(5), 50421; https://doi.org/10.31083/JIN50421 (registering DOI)

Abstract

Download

123

The Neuroprotective Role of a Caspase-1 Inhibitor Against Apoptosis via Inhibition of Glial Hyperactivation in a Mouse Model of Epilepsy

Open Access 9 May 2026Original Research

The Neuroprotective Role of a Caspase-1 Inhibitor Against Apoptosis via Inhibition of Glial Hyperactivation in a Mouse Model of Epilepsy

Hui Cai, Xinran Xu, Xuerui Zhuo, Zhe Liu, Hao Liu, Yiming Sun

J. Integr. Neurosci. 2026, 25(5), 49777; https://doi.org/10.31083/JIN49777 (registering DOI)

Abstract

Download

Longitudinal Reorganization of Local Brain Activity Following Acute Basal Ganglia Infarction: Combined Metrics of Amplitude and Dynamics Reveal Neural Substrates Underlying Motor Recovery

Open Access 9 May 2026Original Research

Longitudinal Reorganization of Local Brain Activity Following Acute Basal Ganglia Infarction: Combined Metrics of Amplitude and Dynamics Reveal Neural Substrates Underlying Motor Recovery

Shijian Chen, Jian Zhang, Yayuan Liu, Xuemei Quan, Qiong Yin, Liya Pan, Zhijian Liang

J. Integr. Neurosci. 2026, 25(5), 47725; https://doi.org/10.31083/JIN47725 (registering DOI)

Abstract

Download

Metabolic Brain Network Reorganization in Temporal Lobe Epilepsy With Aware or Impaired Awareness Seizures

Open Access 9 May 2026Original Research

Metabolic Brain Network Reorganization in Temporal Lobe Epilepsy With Aware or Impaired Awareness Seizures

Jingke Xiao, Fan Yang, Hanlin Zhang, Jiangyan Liu

J. Integr. Neurosci. 2026, 25(5), 47320; https://doi.org/10.31083/JIN47320 (registering DOI)

Abstract

Download

111