Volume 30 Issue 3 2025 - (March 2025)

• Open Access Original Research

  Novel Plasma Biomarkers for Alzheimer’s Disease: Insights from Organotypic Brain Slice and Microcontact Printing Techniques

  Sakir Necat Yilmaz, Katharina Steiner, Josef Marksteiner, Klaus Faserl, ... Christian Humpel

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36257; https://doi.org/10.31083/FBL36257

  (This article belongs to the Special Issue Exploring Pathomechanisms, Novel Targets, and New Interventions for Neurological and Neuropsychiatric Disorders)

  Abstract Full Text PDF(1.49MB)

  87

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  1

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  266

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• Open Access Retraction

  Retraction: Zhu et al. Resveratrol reverts Streptozotocin-induced diabetic nephropathy. Frontiers in Bioscience (Landmark Edition). 2020; 25: 699–709

  Frontiers in Bioscience-Landmark Editorial Office

  Front. Biosci. (Landmark Ed) 2025, 30(3), 39230; https://doi.org/10.31083/FBL39230

  Abstract Full Text PDF(177.00KB)

  37

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  213

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• Open Access Original Research

  High-Intensity Interval Training Decreases Circulating HMGB1 in Individuals with Insulin Resistance: Plasma Lipidomics Correlate with Associated Cardiometabolic Benefits

  Gabriela Martinez Bravo, Prabu Paramasivam, Gabriella F. Bellissimo, Quiteria Jacquez, ... Roberto Ivan Mota Alvidrez

  Front. Biosci. (Landmark Ed) 2025, 30(3), 31396; https://doi.org/10.31083/FBL31396

  Abstract Full Text PDF(5.97MB)

  70

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  2

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  252

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• Open Access Original Research

  Plasma Lipidomics, Gut Microbiota Profile, and Phenotype of Adipose Tissue in an ApoE^-/- Mouse Model of Plaque Instability

  Guanlin Yang, Xin Tan, Qiong Zhai, Yuewu Wang, ... LiLi Bao

  Front. Biosci. (Landmark Ed) 2025, 30(3), 27236; https://doi.org/10.31083/FBL27236

  Abstract Full Text PDF(22.98MB)

  72

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  1

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  211

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• Open Access Review

  CD44 and Its Role in Solid Cancers – A Review: From Tumor Progression to Prognosis and Targeted Therapy

  João Martins Gama, Rui Caetano Oliveira

  Front. Biosci. (Landmark Ed) 2025, 30(3), 24821; https://doi.org/10.31083/FBL24821

  Abstract Full Text PDF(4.46MB)

  184

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  3

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  303

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• Open Access Original Research

  NOL6 Promotes Tumor Progression by Facilitating Cancer Cell-Induced Platelet Aggregation and Angiogenesis in Breast Cancer

  Tingting Zhang, Cheng Lu, Mingming Lv, Shengwang Du, Xinjun Wu

  Front. Biosci. (Landmark Ed) 2025, 30(3), 25361; https://doi.org/10.31083/FBL25361

  Abstract Full Text PDF(32.43MB)

  41

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  126

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• Open Access Original Research

  Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer

  Yan-Yan Wu, Liu-Shen-Yan Yu, Han-Yu Zhou, Jun-Chao Xue

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26045; https://doi.org/10.31083/FBL26045

  Abstract Full Text PDF(9.76MB)

  74

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  187

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• Open Access Review

  Allergy Treatment: A Comprehensive Review of Nanoparticle-based Allergen Immunotherapy

  Mabrouk A. Abo-Zaid, Reem M. Elsapagh, Nourhan S. Sultan, Wedad Mawkili, ... Ahmed H. Ismail

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26550; https://doi.org/10.31083/FBL26550

  Abstract Full Text PDF(6.39MB)

  283

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  1

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  370

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• Open Access Review

  Mast Cells and Microbiome in Health and Disease

  Vincenzo Papa, Federica Li Pomi, Mario Di Gioacchino, Rocco Mangifesta, ... Sebastiano Gangemi

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26283; https://doi.org/10.31083/FBL26283

  Abstract Full Text PDF(3.49MB)

  321

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  6

  Citations

  356

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• Open Access Original Research

  Improvement of RSV-Induced Asthma in Mice: A Study Based on Icariin-Mediated PD-1

  Jiayao Fu, Xiaohong Wang

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26061; https://doi.org/10.31083/FBL26061

  Abstract Full Text PDF(4.95MB)

  41

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  1

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  139

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• Open Access Review

  Myeloid-Derived Suppressor Cells: Implications in Cancer Immunology and Immunotherapy

  Juan F. Santibanez

  Front. Biosci. (Landmark Ed) 2025, 30(3), 25203; https://doi.org/10.31083/FBL25203

  Abstract Full Text PDF(2.90MB)

  144

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  2

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  179

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• Open Access Review

  Monitoring Autophagy in Human Aging: Key Cell Models and Insights

  Tatiana M. Moreno, Jose L. Nieto-Torres, Caroline Kumsta

  Front. Biosci. (Landmark Ed) 2025, 30(3), 27091; https://doi.org/10.31083/FBL27091

  (This article belongs to the Special Issue Boosting Autophagy to Fight Aging and Age-Related Diseases)

  Abstract Full Text PDF(6.31MB)

  159

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  2

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  207

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• Open Access Original Research

  Small Extracellular Vesicles Promote HBV Replication via METTL3–IGF2BP2-Mediated m6A Modification

  Jie Zhang, Ling Yu, Xinyu Wu, Wanlong Pan

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36291; https://doi.org/10.31083/FBL36291

  Abstract Full Text PDF(14.94MB)

  96

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  1

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  245

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• Open Access Review

  Emerging Therapeutic Agents and Nanotechnology-Driven Innovations in Psoriasis Management

  Tarnjot Kaur, Nikita Hinge, Sudeep Pukale, Mohd Nazam Ansari, ... Jyoti Upadhyay

  Front. Biosci. (Landmark Ed) 2025, 30(3), 27910; https://doi.org/10.31083/FBL27910

  Abstract Full Text PDF(5.13MB)

  161

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  2

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  241

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• Open Access Original Research

  An MRI Radiogenomic Signature to Characterize the Transcriptional Heterogeneity Associated with Prognosis and Biological Functions in Glioblastoma

  Xiaoqing Zhang, Xiaoyu Zhang, Jie Zhu, Zhuoya Yi, ... Guoxian Huang

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36348; https://doi.org/10.31083/FBL36348

  Abstract Full Text PDF(10.64MB)

  51

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  9

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  141

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• Open Access Review

  Ubiquitin Ligases in Control: Regulating NLRP3 Inflammasome Activation

  Swarna Beesetti

  Front. Biosci. (Landmark Ed) 2025, 30(3), 25970; https://doi.org/10.31083/FBL25970

  Abstract Full Text PDF(6.96MB)

  158

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  4

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  327

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• Open Access Original Research

  Leukemia Inhibitory Factor Attenuates Hypoxic–Ischemic White Matter Injury via NLRP3 Inflammasome Activity Suppressing Through the Nrf2/HO-1 Pathway

  Liang Huo, Xueyan Liu, Hua Wang

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36630; https://doi.org/10.31083/FBL36630

  (This article belongs to the Special Issue Regulated Cell Death and Disease)

  Abstract Full Text PDF(9.27MB)

  86

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  202

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• Open Access Review

  Interplay Between Polyphenols and Autophagy: Insights From an Aging Perspective

  Alejandro Ponce-Mora, Nicolle Andrea Salazar, Alicia Domenech-Bendaña, Antonella Locascio, ... Lucia Gimeno-Mallench

  Front. Biosci. (Landmark Ed) 2025, 30(3), 25728; https://doi.org/10.31083/FBL25728

  (This article belongs to the Special Issue Boosting Autophagy to Fight Aging and Age-Related Diseases)

  Abstract Full Text PDF(690.35KB)

  84

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  2

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  206

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• Open Access Original Research

  Transcription Factor FOSL1 Promotes Cisplatin Resistance in Non-Small Cell Lung Cancer Cells by Modulating the Wnt3a/β-Catenin Signaling through Upregulation of PLIN3 Expression

  Wanning Tong, Jianjun Sun, Bin Shen, Yaohua Hu, ... Zhigang Cai

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26898; https://doi.org/10.31083/FBL26898

  Abstract Full Text PDF(12.76MB)

  68

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  2

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  213

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• Open Access Original Research

  3D Bioprinting of Cultivated Meat Followed by the Development of a Fine-Tuned YOLO Model for the Detection and Counting of Lipoblasts, Fibroblasts, and Myogenic Cells

  Rozaliia Nabiullina, Sergey Golovin, Evgeniya Kirichenko, Mikhail Petrushan, ... Stanislav Rodkin

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36266; https://doi.org/10.31083/FBL36266

  Abstract Full Text PDF(28.60MB)

  127

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  3

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  475

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• Open Access Original Research

  Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells

  Rongfeng Dai, Yu Qian, Siqi Liu, Xi Zou, ... Zhuo Sun

  Front. Biosci. (Landmark Ed) 2025, 30(3), 27954; https://doi.org/10.31083/FBL27954

  Abstract Full Text PDF(5.84MB)

  58

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  1

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  148

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• Open Access Original Research

  Comparative Study of Structural and Functional Rearrangements in Skeletal Muscle Mitochondria of SOD1-G93A Transgenic Mice at Pre-, Early-, and Late-Symptomatic Stages of ALS Progression

  Natalia V. Belosludtseva, Anna I. Ilzorkina, Mikhail V. Dubinin, Irina B. Mikheeva, Konstantin N. Belosludtsev

  Front. Biosci. (Landmark Ed) 2025, 30(3), 28260; https://doi.org/10.31083/FBL28260

  Abstract Full Text PDF(26.69MB)

  95

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  2

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  226

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• Open Access Review

  Chronic Inflammation to Cancer: The Impact of Oxidative Stress on DNA Methylation

  Olivia M. Damiano, Aaron J. Stevens, Diane N. Kenwright, Annika R. Seddon

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26142; https://doi.org/10.31083/FBL26142

  Abstract Full Text PDF(5.27MB)

  134

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  5

  Citations

  291

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• Open Access Review

  Significance of Macrophage-Mediated Inflammatory Response in Ocular Inflammatory Complications

  Sara McMahon, Tori Spector, Kota V Ramana

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26698; https://doi.org/10.31083/FBL26698

  Abstract Full Text PDF(3.75MB)

  106

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  3

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  143

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• Open Access Original Research

  Dapagliflozin Attenuates Myocardial Inflammation and Apoptosis after Coronary Microembolization in Rats by Regulating the SIRT1/NF-κB Signaling Pathway

  Tao Li, Chang-Jun Luo, Ze-Qiang Yi, Lang Li

  Front. Biosci. (Landmark Ed) 2025, 30(3), 27082; https://doi.org/10.31083/FBL27082

  Abstract Full Text PDF(31.20MB)

  91

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  188

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• Open Access Editorial

  Potential Genetic Approach to Specific Primary Immunodeficiencies: Which Perspectives?

  Giuseppe Murdaca, Francesca Paladin, Sebastiano Gangemi

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36795; https://doi.org/10.31083/FBL36795

  Abstract Full Text PDF(200.08KB)

  50

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  89

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• Open Access Review

  Possible Role of Platelets in the Development and Progression of Non-Alcoholic Fatty Liver Disease

  Anna F. Sheptulina, Ekaterina O. Liusina, Olga A. Zlobovskaya, Anton R. Kiselev, Oxana M. Drapkina

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26748; https://doi.org/10.31083/FBL26748

  Abstract Full Text PDF(4.84MB)

  97

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  218

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• Open Access Editorial

  Revisiting the Role of Platelet-Activating Factor in COVID-19-Induced Cardiovascular Complications

  Smaragdi Antonopoulou

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36981; https://doi.org/10.31083/FBL36981

  Abstract Full Text PDF(205.49KB)

  27

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• Open Access Opinion

  NO Pain! No Cancer? The Crosstalk Between Nociception, ROS, and Cancer Development

  Tzu-Yin Chen, Tohru Yoshioka, Wen-Li Hsu

  Front. Biosci. (Landmark Ed) 2025, 30(3), 31328; https://doi.org/10.31083/FBL31328

  (This article belongs to the Special Issue Mitochondria Targeting Strategies for Treatment of Human Diseases)

  Abstract Full Text PDF(754.97KB)

  52

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  149

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• Open Access Original Research

  A Quality by Design (QbD) Project of Human Dermal Fibroblast and its Therapeutic Effects on Managing Degenerative Intervertebral Disc Fibrosis in Rabbit and Cynomolgus Monkey

  Li Zhou, Hongsheng Li, Chen Chen, Hao Yang, ... Shen’ao Zhou

  Front. Biosci. (Landmark Ed) 2025, 30(3), 28062; https://doi.org/10.31083/FBL28062

  Abstract Full Text PDF(20.28MB)

  71

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  180

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• Open Access Review

  Historical View and Some Unsolved Problems in Red Blood Cell Membrane Research

  Ingolf Bernhardt, Lars Kaestner

  Front. Biosci. (Landmark Ed) 2025, 30(3), 25331; https://doi.org/10.31083/FBL25331

  (This article belongs to the Special Issue Red Blood Cell in Health and Disease)

  Abstract Full Text PDF(1.26MB)

  315

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  2

  Citations

  412

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• Open Access Original Research

  Scutellarin Attenuates Pro-Inflammatory Foam Cell Formation and Facilitates M2 Polarization in Microglia during Copper Homeostasis Imbalance via the MAPK Signaling Pathway

  Qiting Zhao, Lingyi Chen, Yantuanjin Ma, Shufen Wang

  Front. Biosci. (Landmark Ed) 2025, 30(3), 36255; https://doi.org/10.31083/FBL36255

  Abstract Full Text PDF(5.23MB)

  66

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  250

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• Open Access Original Research

  Loss of Atoh8 Affects Neurocranial and Axial Skeleton Development in Zebrafish

  Ninfa Fragale, Satya Srirama Karthik Divvela, Victoria Clare Williams-Ward, Beate Brand-Saberi

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26806; https://doi.org/10.31083/FBL26806

  Abstract Full Text PDF(4.43MB)

  125

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  198

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• Open Access Original Research

  CD47 Contributes to the Proliferation of Breast Cancer

  Junbin Wang, Xia Wu, Xuejian Liu, Ying Xu

  Front. Biosci. (Landmark Ed) 2025, 30(3), 28210; https://doi.org/10.31083/FBL28210

  Abstract Full Text PDF(6.20MB)

  63

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  189

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• Open Access Original Research

  cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy

  Huiyang Li, Xin Wang, Xinping Luo, Haiming Shi, Jian Li

  Front. Biosci. (Landmark Ed) 2025, 30(3), 26084; https://doi.org/10.31083/FBL26084

  Abstract Full Text PDF(12.72MB)

  158

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  3

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  343

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