Volume 25, Issue 4 (April 2026)

Astrocytes and Their Role in the Development and Progression of Alzheimer’s Disease: Gatekeepers of Neurodegeneration

Open Access 22 Apr 2026Review

Astrocytes and Their Role in the Development and Progression of Alzheimer’s Disease: Gatekeepers of Neurodegeneration

Irena Svobodova, Zdenka Bendova, Jiri Novotny

J. Integr. Neurosci. 2026, 25(4), 49765; https://doi.org/10.31083/JIN49765

Abstract

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277

Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling

Open Access 22 Apr 2026Short Communication

Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling

Spas Kitov, Tanya Deneva, Maria-Florance Kitova, Lyudmila Kitova, Kristina Stoyanova, Iliana Petrova, Drozdstoy Stoyanov

J. Integr. Neurosci. 2026, 25(4), 49628; https://doi.org/10.31083/JIN49628

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

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231

Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale

Open Access 22 Apr 2026Original Research

Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale

Nuo Ma, Juan Tao, Qiong Dong, Qiuyue Yu, Haichao Wang, Ping Li, Quan Yuan, Aiping Jin, Peng Gao, Li Gong

J. Integr. Neurosci. 2026, 25(4), 49070; https://doi.org/10.31083/JIN49070

Abstract

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164

Atractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury

Open Access 22 Apr 2026Original Research

Atractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury

Zhenwei Li, Chao Fang, Chengcheng Feng, Zuomeng Wu, Chenhao Zhao, Cailiang Shen

J. Integr. Neurosci. 2026, 25(4), 47565; https://doi.org/10.31083/JIN47565

Abstract

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275

Functional Connectivity Alterations in the Cholinergic Neural Circuits of Patients With Alzheimer’s Disease: A Donepezil Intervention Study Using Resting-State Functional Magnetic Resonance Imaging

Open Access 21 Apr 2026Short Communication

Functional Connectivity Alterations in the Cholinergic Neural Circuits of Patients With Alzheimer’s Disease: A Donepezil Intervention Study Using Resting-State Functional Magnetic Resonance Imaging

Yufei Guo, Zhenzhong Zhang, Bo Chen, Hao Liu, Fuquan Wei, Xiaozheng Liu, Zhongwei Guo

J. Integr. Neurosci. 2026, 25(4), 50039; https://doi.org/10.31083/JIN50039

Abstract

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159

Targeting Lipid Metabolism in Alzheimer’s Disease: Emerging Insights and Future Directions

Open Access 21 Apr 2026Review

Targeting Lipid Metabolism in Alzheimer’s Disease: Emerging Insights and Future Directions

Jeyakumar Balakrishnan, Suganya Kannan, Kathiresan Shanmugam, Dhavamani Sugasini

J. Integr. Neurosci. 2026, 25(4), 48436; https://doi.org/10.31083/JIN48436

Abstract

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353

Investigating Gender Differences in the Link Between Physical Activity and Depression in Middle-aged and Older Chinese Adults via Network Analysis and Simulation Study

Open Access 21 Apr 2026Original Research

Investigating Gender Differences in the Link Between Physical Activity and Depression in Middle-aged and Older Chinese Adults via Network Analysis and Simulation Study

Ying Xiong, Yiguo Deng, Miao Yu, Qihan Zhang, Siyu Li, Jiaying Li, Zengjie Ye

J. Integr. Neurosci. 2026, 25(4), 47468; https://doi.org/10.31083/JIN47468

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

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201

The Role of Artificial Intelligence in Diagnosing Acute Ischemic Stroke Using Diffusion MRI: A Multicenter External Validation Study

Open Access 21 Apr 2026Original Research

The Role of Artificial Intelligence in Diagnosing Acute Ischemic Stroke Using Diffusion MRI: A Multicenter External Validation Study

Beyza Nur Kuzan, Ali Abbasian Ardakani, Mahmut Esat Aykan, Mustafa Demir, Servan Yaşar, Mehmet Semih Çakır, Afshin Mohammadi, Taha Yusuf Kuzan

J. Integr. Neurosci. 2026, 25(4), 48811; https://doi.org/10.31083/JIN48811

(This article belongs to the Special Issue Advancing Neurological Care with AI and Digital Twins)

Abstract

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291

FPS-ZM1 Exerts Neuroprotection in Cardiac-Arrest Mice through Inhibiting Oxidative Stress and Pyroptosis via the HMGB1/RAGE Axis

Open Access 17 Apr 2026Original Research

FPS-ZM1 Exerts Neuroprotection in Cardiac-Arrest Mice through Inhibiting Oxidative Stress and Pyroptosis via the HMGB1/RAGE Axis

Ying Zhu, Qianhui Lin, Yanping Wu, Jing Hou, Liping Lu, Song Xu, Ling Li, Zhui Yu

J. Integr. Neurosci. 2026, 25(4), 50023; https://doi.org/10.31083/JIN50023

Abstract

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216

Involvement of the Primary Auditory Cortex-Basolateral Amygdala Circuit in Altered Conditioned Fear Memory Retrieval Following Electromagnetic Field Exposure in Mice

Open Access 17 Apr 2026Original Research

Involvement of the Primary Auditory Cortex-Basolateral Amygdala Circuit in Altered Conditioned Fear Memory Retrieval Following Electromagnetic Field Exposure in Mice

Zhilin Cui, Lei Shi, Meiying Yang, Chenxu Chang, Shunkang Jin, Yanhui Hao, Xuelong Zhao, Yanjie Lu, Yang Li, Hongyan Zuo

J. Integr. Neurosci. 2026, 25(4), 48640; https://doi.org/10.31083/JIN48640

Abstract

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184

Inter-Hemispheric Asymmetry and Intra-Hemispheric Discrepancy of Electroencephalographic Activities in Patients With Idiopathic Rapid Eye Movement Sleep Behavior Disorder: An Exploratory Study

Open Access 17 Apr 2026Original Research

Inter-Hemispheric Asymmetry and Intra-Hemispheric Discrepancy of Electroencephalographic Activities in Patients With Idiopathic Rapid Eye Movement Sleep Behavior Disorder: An Exploratory Study

Zhijun Zhong, Qi Li, Xueliang Zou, Mengmeng Wang, Qian Ouyang, Chunmei Gan, Fang Yi, Zifan Xu, Dongyuan Yao

J. Integr. Neurosci. 2026, 25(4), 47930; https://doi.org/10.31083/JIN47930

Abstract

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174

A Capacitance-Based System for Measuring Licking Behaviour in Rodents With Sub-Second Precision

Open Access 17 Apr 2026Original Research

A Capacitance-Based System for Measuring Licking Behaviour in Rodents With Sub-Second Precision

Yuliia Martynova, José Antonio González

J. Integr. Neurosci. 2026, 25(4), 49809; https://doi.org/10.31083/JIN49809

(This article belongs to the Special Issue Scottish Neuroscience-2026)

Abstract

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183

The Lysosomal-Associated Protein Transmembrane Family and Neurological Disorders: Therapeutic Potential and Future Research Directions

Open Access 13 Apr 2026Review

The Lysosomal-Associated Protein Transmembrane Family and Neurological Disorders: Therapeutic Potential and Future Research Directions

Zitong Wang, Yang Pan, Min Shu, Li Zou

J. Integr. Neurosci. 2026, 25(4), 47903; https://doi.org/10.31083/JIN47903

Abstract

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202

Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice

Open Access 13 Apr 2026Original Research

Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice

Suping Qin, Jingjing Guo, Bohui Yuan, Xuejiao Zhang, Shuowei Wang, Yi Ding, Tianxin Zhang, Xiaotian Wang, Dexu Sun, Feng Zhou, Xiaomei Liu

J. Integr. Neurosci. 2026, 25(4), 47364; https://doi.org/10.31083/JIN47364

Abstract

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146

Bilingual Experience and Functional Neuroplasticity: Insights From Resting-State Functional Connectivity and Functional Network Topology in the Brain

Open Access 31 Mar 2026Review

Bilingual Experience and Functional Neuroplasticity: Insights From Resting-State Functional Connectivity and Functional Network Topology in the Brain

Yongqiang Jiang, Ling Zhao, Yani Zhang, Yufei Yang, Naiyi Wang, Xiaojin Liu

J. Integr. Neurosci. 2026, 25(4), 49400; https://doi.org/10.31083/JIN49400

Abstract

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246

Electroacupuncture Combined With Paroxetine Improves Depression-Like Behavior in Rats by Regulating SIRT2/AMPAR in the Hippocampal Dentate Gyrus

Open Access 31 Mar 2026Original Research

Electroacupuncture Combined With Paroxetine Improves Depression-Like Behavior in Rats by Regulating SIRT2/AMPAR in the Hippocampal Dentate Gyrus

Zhinan Zhang, Shengtao Huang, Zheng Li, Xiaowen Cai, Xiaoke Qiu, Zhangjin Zhang, Yong Huang

J. Integr. Neurosci. 2026, 25(4), 44692; https://doi.org/10.31083/JIN44692

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

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227

Volume 25, Issue 4 (2026)

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Astrocytes and Their Role in the Development and Progression of Alzheimer’s Disease: Gatekeepers of Neurodegeneration

Open Access 22 Apr 2026Review

Astrocytes and Their Role in the Development and Progression of Alzheimer’s Disease: Gatekeepers of Neurodegeneration

Irena Svobodova, Zdenka Bendova, Jiri Novotny

J. Integr. Neurosci. 2026, 25(4), 49765; https://doi.org/10.31083/JIN49765

Abstract

Download

277

Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling

Open Access 22 Apr 2026Short Communication

Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling

Spas Kitov, Tanya Deneva, Maria-Florance Kitova, Lyudmila Kitova, Kristina Stoyanova, Iliana Petrova, Drozdstoy Stoyanov

J. Integr. Neurosci. 2026, 25(4), 49628; https://doi.org/10.31083/JIN49628

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

Download

231

Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale

Open Access 22 Apr 2026Original Research

Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale

Nuo Ma, Juan Tao, Qiong Dong, Qiuyue Yu, Haichao Wang, Ping Li, Quan Yuan, Aiping Jin, Peng Gao, Li Gong

J. Integr. Neurosci. 2026, 25(4), 49070; https://doi.org/10.31083/JIN49070

Abstract

Download

164

Atractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury

Open Access 22 Apr 2026Original Research

Atractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury

Zhenwei Li, Chao Fang, Chengcheng Feng, Zuomeng Wu, Chenhao Zhao, Cailiang Shen

J. Integr. Neurosci. 2026, 25(4), 47565; https://doi.org/10.31083/JIN47565

Abstract

Download

275

Functional Connectivity Alterations in the Cholinergic Neural Circuits of Patients With Alzheimer’s Disease: A Donepezil Intervention Study Using Resting-State Functional Magnetic Resonance Imaging

Open Access 21 Apr 2026Short Communication

Functional Connectivity Alterations in the Cholinergic Neural Circuits of Patients With Alzheimer’s Disease: A Donepezil Intervention Study Using Resting-State Functional Magnetic Resonance Imaging

Yufei Guo, Zhenzhong Zhang, Bo Chen, Hao Liu, Fuquan Wei, Xiaozheng Liu, Zhongwei Guo

J. Integr. Neurosci. 2026, 25(4), 50039; https://doi.org/10.31083/JIN50039

Abstract

Download

159

Targeting Lipid Metabolism in Alzheimer’s Disease: Emerging Insights and Future Directions

Open Access 21 Apr 2026Review

Targeting Lipid Metabolism in Alzheimer’s Disease: Emerging Insights and Future Directions

Jeyakumar Balakrishnan, Suganya Kannan, Kathiresan Shanmugam, Dhavamani Sugasini

J. Integr. Neurosci. 2026, 25(4), 48436; https://doi.org/10.31083/JIN48436

Abstract

Download

353

Investigating Gender Differences in the Link Between Physical Activity and Depression in Middle-aged and Older Chinese Adults via Network Analysis and Simulation Study

Open Access 21 Apr 2026Original Research

Investigating Gender Differences in the Link Between Physical Activity and Depression in Middle-aged and Older Chinese Adults via Network Analysis and Simulation Study

Ying Xiong, Yiguo Deng, Miao Yu, Qihan Zhang, Siyu Li, Jiaying Li, Zengjie Ye

J. Integr. Neurosci. 2026, 25(4), 47468; https://doi.org/10.31083/JIN47468

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

Download

201

The Role of Artificial Intelligence in Diagnosing Acute Ischemic Stroke Using Diffusion MRI: A Multicenter External Validation Study

Open Access 21 Apr 2026Original Research

The Role of Artificial Intelligence in Diagnosing Acute Ischemic Stroke Using Diffusion MRI: A Multicenter External Validation Study

Beyza Nur Kuzan, Ali Abbasian Ardakani, Mahmut Esat Aykan, Mustafa Demir, Servan Yaşar, Mehmet Semih Çakır, Afshin Mohammadi, Taha Yusuf Kuzan

J. Integr. Neurosci. 2026, 25(4), 48811; https://doi.org/10.31083/JIN48811

(This article belongs to the Special Issue Advancing Neurological Care with AI and Digital Twins)

Abstract

Download

291

FPS-ZM1 Exerts Neuroprotection in Cardiac-Arrest Mice through Inhibiting Oxidative Stress and Pyroptosis via the HMGB1/RAGE Axis

Open Access 17 Apr 2026Original Research

FPS-ZM1 Exerts Neuroprotection in Cardiac-Arrest Mice through Inhibiting Oxidative Stress and Pyroptosis via the HMGB1/RAGE Axis

Ying Zhu, Qianhui Lin, Yanping Wu, Jing Hou, Liping Lu, Song Xu, Ling Li, Zhui Yu

J. Integr. Neurosci. 2026, 25(4), 50023; https://doi.org/10.31083/JIN50023

Abstract

Download

216

Involvement of the Primary Auditory Cortex-Basolateral Amygdala Circuit in Altered Conditioned Fear Memory Retrieval Following Electromagnetic Field Exposure in Mice

Open Access 17 Apr 2026Original Research

Involvement of the Primary Auditory Cortex-Basolateral Amygdala Circuit in Altered Conditioned Fear Memory Retrieval Following Electromagnetic Field Exposure in Mice

Zhilin Cui, Lei Shi, Meiying Yang, Chenxu Chang, Shunkang Jin, Yanhui Hao, Xuelong Zhao, Yanjie Lu, Yang Li, Hongyan Zuo

J. Integr. Neurosci. 2026, 25(4), 48640; https://doi.org/10.31083/JIN48640

Abstract

Download

184

Inter-Hemispheric Asymmetry and Intra-Hemispheric Discrepancy of Electroencephalographic Activities in Patients With Idiopathic Rapid Eye Movement Sleep Behavior Disorder: An Exploratory Study

Open Access 17 Apr 2026Original Research

Inter-Hemispheric Asymmetry and Intra-Hemispheric Discrepancy of Electroencephalographic Activities in Patients With Idiopathic Rapid Eye Movement Sleep Behavior Disorder: An Exploratory Study

Zhijun Zhong, Qi Li, Xueliang Zou, Mengmeng Wang, Qian Ouyang, Chunmei Gan, Fang Yi, Zifan Xu, Dongyuan Yao

J. Integr. Neurosci. 2026, 25(4), 47930; https://doi.org/10.31083/JIN47930

Abstract

Download

174

A Capacitance-Based System for Measuring Licking Behaviour in Rodents With Sub-Second Precision

Open Access 17 Apr 2026Original Research

A Capacitance-Based System for Measuring Licking Behaviour in Rodents With Sub-Second Precision

Yuliia Martynova, José Antonio González

J. Integr. Neurosci. 2026, 25(4), 49809; https://doi.org/10.31083/JIN49809

(This article belongs to the Special Issue Scottish Neuroscience-2026)

Abstract

Download

183

The Lysosomal-Associated Protein Transmembrane Family and Neurological Disorders: Therapeutic Potential and Future Research Directions

Open Access 13 Apr 2026Review

The Lysosomal-Associated Protein Transmembrane Family and Neurological Disorders: Therapeutic Potential and Future Research Directions

Zitong Wang, Yang Pan, Min Shu, Li Zou

J. Integr. Neurosci. 2026, 25(4), 47903; https://doi.org/10.31083/JIN47903

Abstract

Download

202

Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice

Open Access 13 Apr 2026Original Research

Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice

Suping Qin, Jingjing Guo, Bohui Yuan, Xuejiao Zhang, Shuowei Wang, Yi Ding, Tianxin Zhang, Xiaotian Wang, Dexu Sun, Feng Zhou, Xiaomei Liu

J. Integr. Neurosci. 2026, 25(4), 47364; https://doi.org/10.31083/JIN47364

Abstract

Download

146

Bilingual Experience and Functional Neuroplasticity: Insights From Resting-State Functional Connectivity and Functional Network Topology in the Brain

Open Access 31 Mar 2026Review

Bilingual Experience and Functional Neuroplasticity: Insights From Resting-State Functional Connectivity and Functional Network Topology in the Brain

Yongqiang Jiang, Ling Zhao, Yani Zhang, Yufei Yang, Naiyi Wang, Xiaojin Liu

J. Integr. Neurosci. 2026, 25(4), 49400; https://doi.org/10.31083/JIN49400

Abstract

Download

246

Electroacupuncture Combined With Paroxetine Improves Depression-Like Behavior in Rats by Regulating SIRT2/AMPAR in the Hippocampal Dentate Gyrus

Open Access 31 Mar 2026Original Research

Electroacupuncture Combined With Paroxetine Improves Depression-Like Behavior in Rats by Regulating SIRT2/AMPAR in the Hippocampal Dentate Gyrus

Zhinan Zhang, Shengtao Huang, Zheng Li, Xiaowen Cai, Xiaoke Qiu, Zhangjin Zhang, Yong Huang

J. Integr. Neurosci. 2026, 25(4), 44692; https://doi.org/10.31083/JIN44692

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

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227