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Influence of Radiation Quality on Cellular, Molecular and Inflammatory Responses in Normal and Malignant Human Cells

Submission deadline: 20 April 2024
Special Issue Editor
  • Isabelle Testard
    CEA, University Grenoble Alpes, CNRS, IRIG-LCBM-UMR5249, Grenoble, France
    Interests: radiobiology; human cells; ionizing radiation; high-LET radiation; DNA damage responses; inflammatory responses; bystander effects
Special Issue Information

Dear Colleagues,

Biological effects of ionizing radiation significantly depend on dose, dose rate, and radiation quality. In addition to DNA lesions and activation of DNA damage signaling pathways, other cellular targets, especially when particulate radiation is involved, may also play an important role in cell or tissue responses. Organelles such as mitochondria, take part in damage signaling, cell death and inflammation through different pathways depending on the dose and LET.

Cellular and molecular lesions can also occur in cells that have not been irradiated but that are located near exposed cells. These non-targeted, or bystander effects can act as a modifier of the cellular responses, and may involve inflammatory processes.

This special issue aims at extending the knowledge of the cellular response mechanisms resulting from different kinds of radiation in normal and malignant human cells or tissues. A special focus on stress and inflammatory responses and their modulation by dose, dose-rate and LET is encouraged, in the context of the development of new radiotherapy modalities but also in relation to the improvement of radioprotection for exposed workers, including those involved in space exploration.

Research papers, including pertinent short communications and topical reviews will be considered.

Dr.  Isabelle Testard
Guest Editor

cancer radiotherapy
space radiation protection
normal and cancer human cells
ionizing radiation
high-LET radiation
DNA damage responses
inflammatory responses
bystander effects
microdosimetry and simulation
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (1 Paper)
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