Protein Folding, Misfolding, Non-Folding, and Assembly

Dear Colleagues,

Following their biosynthesis in the cell, proteins can fold, misfold, or stay non-folded to different degrees (i.e., be intrinsically disordered as a whole or contain intrinsically disordered regions). Although both folding and non-folding processes are associated with protein functionality, protein misfolding is linked to the pathogenesis of various diseases. There is an intricate interplay between these processes, where folded proteins can (at least partially) unfold to become functional, and where disordered proteins undergo (at least partial) induced folding during their functionality. Both ordered and intrinsically disordered proteins can misfold, and due to the action of the cellular proteostasis machinery, misfolded proteins can recover their original folded or intrinsically disordered states. Furthermore, protein functionality and misfolding are intimately linked to the protein assembly, where various functional and pathological complexes are formed. This Special Issue is dedicated to various aspects of protein folding, misfolding, non-folding, and assembly and will consider studies focused on the characterization of these processes and the roles of their interplay in maintaining the cellular proteostasis. Original experimental, computational and theoretical studies are welcomed, together with reviews, comments and opinions.

Prof. Vladimir N. Uversky

Guest Editor

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.