IMR Press / FBL / Volume 28 / Issue 9 / DOI: 10.31083/j.fbl2809207
Open Access Review
The Roles and Targeting of Tumor-Associated Macrophages
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1 Shenzhen Bay Laboratory, 518132 Shenzhen, Guangdong, China
*Correspondence: (Qianqian Gao)
Front. Biosci. (Landmark Ed) 2023, 28(9), 207;
Submitted: 27 February 2023 | Revised: 28 April 2023 | Accepted: 9 May 2023 | Published: 15 September 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Tumor-associated macrophages (TAMs) are the most abundant infiltrating immune cells in the tumor microenvironment (TME) and play an important role in tumor progression. Clinically, the increase of TAMs infiltration is linked to poor prognosis of patients with various cancer types. Multiple studies have demonstrated that reducing or reprogramming TAMs can inhibit the occurrence or development of tumors. Therefore, TAMs have been identified as novel targets for the treatment of cancer therapy. In this review, the origin, polarization, roles, and targeting of TAMs in malignancies, are discussed.

tumor-associated macrophages
tumor microenvironment
macrophage roles
macrophage targeting
cancer therapy
Fig. 1.
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