IMR Press / FBL / Volume 28 / Issue 11 / DOI: 10.31083/j.fbl2811286
Open Access Review
Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development
Yuanyuan Li1,†Yang Yu1,†Lei Yang1,*Rui Wang2,*
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1 Department of Medical Oncology, Affiliated Tumor Hospital, Nantong University, 226300 Nantong, Jiangsu, China
2 Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, 210016 Nanjing, Jiangsu, China
*Correspondence: (Lei Yang); (Rui Wang)
These authors contributed equally.
Front. Biosci. (Landmark Ed) 2023, 28(11), 286;
Submitted: 19 April 2023 | Revised: 18 July 2023 | Accepted: 20 July 2023 | Published: 8 November 2023
(This article belongs to the Special Issue Oxidative Stress in Cancer)
Copyright: © 2023 The Author(s). Published by IMR Press.

This is an open access article under the CC BY 4.0 license.


Oxidative stress (OS) is linked to hepatocellular carcinoma (HCC) progression. HCC may develop as a result of genetic changes, including oxidative injury to both nuclear and mitochondrial DNA. Signaling pathways regulated by OS, such as Wnt/β-catenin and Notch pathways, are vital regulators in developing HCC. OS-mediated activation of transcription factors, including nuclear factor-κB and p53, among others, is capable of regulating the redox state of HCC cells. OS also affects the tumor microenvironment, which, in turn, regulates HCC progression. In HCC, reactive oxygen species (ROS) can potentially enhance tumor cell proliferation, metastasis, and resistance to treatment. However, elevated ROS levels can cause cytotoxicity and trigger apoptosis in HCC cells. This review highlights and explores potential oxidative stress-related treatment targets in HCC, offering novel insights for clinical therapies.

oxidative stress
genetic changes
signaling pathways
transcription factors
tumor microenvironment
treatment targets
Fig. 1.
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