IMR Press / FBL / Volume 27 / Issue 6 / DOI: 10.31083/j.fbl2706171
Open Access Review
The Significance of the Ocular Adverse Effect Induced by Systemic Taxane Application
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1 Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, 710032 Xi′an, Shaanxi, China
2 Department of Chinese Materia Medica, College of Life Sciences, Northwestern University, 710069 Xi′an, Shaanxi, China
3 Department of Ophthalmology, The First Affiliated Hospital of Northwest University (Xi′an First Hospital), 710002 Xi′an, Shaanxi, China
*Correspondence: fierywang@126.com (Guo-Rui Dou); chuzhaojie2009@163.com (Zhao-Jie Chu)
These authors contributed equally.
Academic Editor: Shikun He
Front. Biosci. (Landmark Ed) 2022, 27(6), 171; https://doi.org/10.31083/j.fbl2706171
Submitted: 7 March 2022 | Revised: 20 April 2022 | Accepted: 22 April 2022 | Published: 31 May 2022
(This article belongs to the Special Issue Recent Advances in Eye and Vision Research)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

In recent years, in-depth research on anti-tumor therapy has brought the emergence of new active chemotherapeutic agents and combination regimens. However, as one of them, taxane drugs are widely used in clinical practice, but it should be noted that many side reactions caused by their application bring some difficulties to routine management. Among the side reactions related to taxane anti-tumor therapy, ocular adverse reactions are occasionally reported and are not life-threatening but may seriously affect patients’ life quality. Thus, the continuation, reduction and cessation of taxane chemotherapy still need to be further evaluated by ophthalmologists and oncologists once the side effects show up. To prevent ocular side reactions, close attention should be paid to complications during medication. To facilitate the oncology department and ophthalmologists to comprehensively understand the ophthalmic adverse reactions of taxane drugs and their possible mechanisms and improve drug use efficiency, we collected relevant literature and reviewed and provided some suggestions for the monitoring and managing of ophthalmic toxicity.

Keywords
paclitaxel
taxane
eye diseases
drug-related side effects and adverse reactions
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