IMR Press / FBL / Volume 27 / Issue 11 / DOI: 10.31083/j.fbl2711313
Open Access Review
Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential Targets
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1 Department of Pharmacy, Daping Hospital, Army Medical University, 400042 Chongqing, China
*Correspondence: (Yao Liu)
Academic Editor: Pietro Gentile
Front. Biosci. (Landmark Ed) 2022, 27(11), 313;
Submitted: 12 August 2022 | Revised: 13 October 2022 | Accepted: 25 October 2022 | Published: 25 November 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Platelets are small, anucleate cellular fragments, which are produced by megakaryocytes, and play a key role in hemostasis and thrombus formation. The differentiation of megakaryocytes from hematopoietic stem cells in bone marrow and the development of megakaryocytes into platelets is a complex process. Various regulatory factorsin megakaryopoiesis including cytokines, growth factors, transcription factors, and gene expression, are all involved in the process of thrombocytopoiesis and play distinct roles in different stages of megakaryocytes development. In this review, we summarize the current state of knowledge ofmultiple regulatory factors including the TPO/Mpl signaling pathway, transcription factors, RasGTPases family, estrogen, and microRNAs. Altogether, we aimed to discuss more molecular mechanisms of megakaryocytes differentiation and maturation, and possess a better understanding of platelet formation.

transcription factors
Ras GTPases family
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CSTC2021jscx-gksbN0013/The Chongqing Clinical Pharmacy Key Specialties Construction Project and The Chongqing Special Project for Technological Innovation 8 and Application Development
cstc2020jsyj-zzysbAX0024/Chongqing Technology Foresight and System Innovation Project
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