IMR Press / FBL / Volume 27 / Issue 11 / DOI: 10.31083/j.fbl2711312
Open Access Review
Research Progress of Targeting Neuro-Immune Inflammation in the Treatment of Alzheimer's Disease
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1 Department of Traditional Chinese Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233 Shanghai, China
2 The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, 150040 Harbin, Heilongjiang, China
*Correspondence: (Shengxi Meng)
These authors contributed equally.
Academic Editor: Antoni Camins
Front. Biosci. (Landmark Ed) 2022, 27(11), 312;
Submitted: 20 July 2022 | Revised: 30 September 2022 | Accepted: 24 October 2022 | Published: 25 November 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system characterized by extracellular senile plaques and the formation of intracellular neurofibrillary tangles. The accumulation of toxic beta-amyloid (Aβ) induces the overproduction of reactive oxygen species (ROS), nitric oxide (NO) and pro-inflammatory cytokines. Accumulating studies suggest that neuroinflammatory mechanism plays an important role in the occurrence and development of AD. Microglia, astrocytes, macrophages, mast cells and T cells are involved in the pathogenesis of AD through neuroimmune mechanisms and inflammatory reactions. In recent years, many new drugs have been developed for the treatment of AD targeting neuroimmune and inflammatory mechanisms. Although some drugs failed in the Ⅲ phase of clinical trial, they made sense on subsequent research. This paper mainly discusses the positive effects on AD according to immunotherapy, anti-inflammatory treatment and regulation of immune inflammation by traditional Chinese medicine, in order to benefit for prevention or treatment of AD in the future.

Alzheimer's disease
neuroimmune regulation
immune cells
ynxg202218/Project of COVID-19 Emergency Response Project of Shanghai Sixth People’s Hospital in 2022
ZY(2021-2023)-0205-04/Three-year Action Plan (2021-2023) of Shanghai Municipality for Further Accelerating the Inheritance, Innovation and Development of Traditional Chinese Medicine
ZY(2021-2023)-0302/Construction of East China Area and Municipal TCM Specialist Disease Alliance
S202210228075/Provincial General Project of Innovation and Entrepreneurship training Program for College students in Heilongjiang Province
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