Resveratrol reverts Streptozotocin-induced diabetic nephropathy

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Article

Huiping Zhu¹, Sen Zhong¹, Haihong Yan¹, Kangyao Wang¹, Lingwei Chen¹, Min Zhou¹, Yunsheng Li^1,*

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¹ Department of Nephrology, The First people’s Hospital of Wenling and The Affiliated Wenling Hospital of Wenzhou Medical university. Wenling, 317500, Zhejiang, P. R. China

Send correspondence to: Yunsheng Li, Department of Nephrology, The First people’s Hospital of Wenling and The Affiliated Wenling Hospital of Wenzhou Medical university. No. 333, Chuanan road, Wenling, Zhejiang, 317500, P. R. China, Tel: 86-15823190731, Fax: 0577-55578238, E-mail: longzhi82544@sina.com

Front. Biosci. (Landmark Ed) 2020, 25(4), 699–709; https://doi.org/10.2741/4829

Published: 1 January 2020

(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)

Abstract

Diabetes causes diabetic nephropathy (DN) which is associated with increased morbidity and mortality in diabetic patients. We tested whether Resveratrol (Res) reverses the systemic effect of Streptozotocin (STZ) induced diabetes and DN. Res treatment opposed the effect of STZ on kidney weight, 24 h urinary albumin excretion, blood urea nitrogen (BUN) and serum creatinine (Scr). Res also decreased DN induced mTOR/ULK1-mediated autophagy and apoptosis and significantly reduced STZ mediated lipid deposition in nephrons, likely by decreasing the levels of lipogenic related proteins (SREBP-1c, ACS) and increased lipidolysis related proteins (PPARα, CPT-1). Together, these findings show the potential of Res in prevention of diabetic nephropathy.

Keywords

Resveratrol

Renal dysfunction

Diabetic nephropathy

mTOR/ULK1 pathway

Autophagy

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