IMR Press / FBL / Volume 25 / Issue 4 / DOI: 10.2741/4828

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

cPKCβII is significant to hypoxic preconditioning in mice cerebrum
Show Less
1 Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
2 Department of Neurology, Hainan Provincial General Hospital, Haikou 570311, China
3 Department of Bioninformatics, School of Basic Medical Sciences and School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
4 Department of Pharmacology, School of Basic Medical Sciences and School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
Send correspondence to: Junfa Li, Department of Neurobiology, Beijing Institute for Neuroscience, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Beijing 100069, PR China, Tel: 8610-8391-1475, Fax: 8610-8395-0060, E-mail:
Front. Biosci. (Landmark Ed) 2020, 25(4), 683–698;
Published: 1 January 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)

Stroke causes significant morbidity and mortality worldwide, for which no satisfactory preventive option currently exists. Hypoxic preconditioning (HPC) is a protective strategy for cerebral ischemic stroke. To this end, we have identified, Conventional protein kinase C (cPKC)BetaII to play an important role in HPC. Pathway analysis and protein–protein interaction network building and functional proteomic exploration was used to identify 38 proteins in 6 Kyoto Encyclopedia of Genes and Genomes pathways that interact with cPKCBetaII in brains subjected to HPC. The role of the oxidative phosphorylation pathway was confirmed by experimental validation, and the demonstration that the activity of the complex I and complex V and expression and activity of Ndufv2 and ATP5d was increased. Ndufv2 was co-localized with PKCBetaII in neurons rather than glial cells. Together, these data show that Ndufv2 and the oxidative phosphorylation pathway play an important role in cPKCBetaII-related HPC mediated signalling, likely as an adaptive neuroprotective mechanism.

OXPHO pathway
PPI network
Cellular Signal Transduction
Figure 1
Back to top