IMR Press / FBE / Volume 4 / Issue 6 / DOI: 10.2741/e521

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Sleep deprivation, sleep apnea and cardiovascular diseases

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1 Hypoxia PathoPhysiology (HP2) Laboratory, Joseph Fourier University, Grenoble, France
2 Inserm unit 1042, Grenoble, France
3 EFCR, Locomotion, Rehabilitation and Physiology Department, Grenoble University Hospital, France
4 Cardiology Department, Grenoble University Hospital, France, Biology and Pathology Institute (IBP), Grenoble University Hospital, France

Academic Editor: Michelle Miller

Front. Biosci. (Elite Ed) 2012, 4(6), 2007–2021;
Published: 1 January 2012
(This article belongs to the Special Issue Sleep, inflammation, oxidation and cardiovascular disease)

Sleep dramatically influences cardiovascular regulation. Changes in sleep duration or quality as seen in sleep disorders may prevent blood pressure to fall during sleep as expected in human physiology. This supports the increased prevalence of hypertension and drug-resistant hypertension in those with sleep loss. Other cardiovascular outcomes i.e. coronary lesions seem to be associated with sleep duration. Systemic inflammation, oxidative stress and endothelial dysfunction seem to be associated with both sleep loss and sleep disorders. The most critical example is Obstructive Sleep Apnea (OSA). Sympathetic activation, oxidative stress and systemic inflammation are the main intermediary mechanisms associated with sleep apnea and intermittent hypoxia. There are now convincing data regarding the associations between hypertension, arrhythmias, stroke, coronary heart disease, increased cardiovascular mortality and OSA. There are also data in OSA and in animal models supporting the link between sleep apnea and atherosclerosis and dysmetabolism. Whether treating sleep apnea enables the reversal of chronic cardiovascular and metabolic consequences of OSA, remains to be studied in adequately designed studies, particularly in comparison with usual treatment strategies.

Sleep disorders
Obstructive sleep apnea
Intermittent hypoxia
Oxidative stress
Endothelial dysfunction
Metabolic dysfunction
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