IMR Press / FBE / Volume 4 / Issue 2 / DOI: 10.2741/e410

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The emerging roles of prohibitins in folliculogenesis

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1 Department of Obstetrics and Gynecology, , Morehouse School of Medicine, Atlanta, Georgia 30310, USA
2 Reproductive Science Research Program, , Morehouse School of Medicine, Atlanta, Georgia 30310, USA
3 Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
4 Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA

*Author to whom correspondence should be addressed.

Academic Editor: Indrajit Chowdhury

Front. Biosci. (Elite Ed) 2012, 4(2), 690–699; https://doi.org/10.2741/e410
Published: 1 January 2012
(This article belongs to the Special Issue Recent progress in reproductive biology)
Abstract

Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain [also known as the prohibitin (PHB) domain] found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans. Prohibitins are ubiquitously expressed and present in multiple cellular compartments including the mitochondria, nucleus, and the plasma membrane, and shuttles between the mitochondria, cytosol and nucleus. Multiple functions have been attributed to the mitochondrial and nuclear prohibitins, including cellular differentiation, anti-proliferation, and morphogenesis. In the present review, we focus on the recent developments in prohibitins research related to folliculogenesis. Based on current research findings, the data suggest that these molecules play important roles in modulating specific responses of granulose cells to follicle stimulating hormone (FSH) by acting at multiple levels of the FSH signal transduction pathway. Understanding the molecular mechanisms by which the intracellular signaling pathways utilize prohibitins in governing folliculogenesis is likely to result in development of strategies to overcome fertility disorders and suppress ovarian cancer growth.

Keywords
Prohibitins
PHB
PHB2
Repressor Of Estrogen Receptor Action
REA
mitochondria
nucleus
Review
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