IMR Press / FBE / Volume 4 / Issue 2 / DOI: 10.2741/e411

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Linking atherosclerosis to Alzheimer’s disease: focus on biomarkers

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1 Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
2 Department of Internal Medicine, Section of Gerontology and Geriatrics, University of Pavia, Azienda Servizi alla Persona, IDR S.Margherita, Via Emilia 12, 27100 Pavia, Italy
3 Cellular Patophisiology and Clinical Immunology Laboratory, IRCCS San Matteo Hospital Foundation, Pavia, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Roberta Ghidoni

Front. Biosci. (Elite Ed) 2012, 4(2), 700–710; https://doi.org/10.2741/e411
Published: 1 January 2012
Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with an important vascular component, ultimately resulting in dementia. Recent years have witnessed an enormous interest in the field of biomarkers in medicine both in the field of atherosclerosis and neurodegeneration. Numerous studies have recently reported altered levels of biomarkers of atherosclerotic vascular disease in patients with AD. This review provides an overview of clinical studies assessing biomarkers of atherosclerosis/vascular disease in the serum/plasma of patients with AD and highlights future directions in the field. The study of specific biomarkers of atherosclerosis in AD can contribute to identify different components of the pathophysiology and the complex mechanisms underlying the progression of the disease.

Keywords
Alzheimer’s disease
Atherosclerosis
Plasma
Serum
Biomarkers
Review
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