IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e379

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease

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1 Geriatric Research Education and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA
2 Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA

*Author to whom correspondence should be addressed.

Academic Editor: Darja Kanduc

Front. Biosci. (Elite Ed) 2012, 4(1), 320–330; https://doi.org/10.2741/e379
Published: 1 January 2012
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)
Abstract

Recent developments in proteomic technologies have enabled the high-throughput, multiplex measurement of large panels of antibodies in biological fluids of patients with immune-driven diseases. Antigen microarrays are increasingly being used to delineate the natural history of autoantibody formation and epitope spread, and thus gain insight into the pathogenesis of autoimmune diseases, as well as into host immunity and its shortcomings. Characterization of autoimmunity that precedes the onset of clinically apparent disease has the potential to guide disease prevention using either conventional immunosupression or novel, antigen-specific tolerizing therapies. In addition, autoantibody profiling has the potential to identify molecular subtypes of a disease, which could allow for prediction of disease outcomes such as severity, tissue damage, and response to therapy.

Keywords
Autoantibody
Protein Microarray
Autoimmunity
Rheumatoid Arthritis
Multiplex
Proteomics
Autoantigen
Review
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