IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e380

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review

STIM and Orai in cellular proliferation and division

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1 Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City – Qatar Foundation, Doha, Qatar

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Elite Ed) 2012, 4(1), 331–341; https://doi.org/10.2741/e380
Published: 1 January 2012
Abstract

Cellular proliferation and division are central processes in the development, survival and evolution of living systems. Transitioning into the cell division phase of the cell cycle encompasses dramatic remodeling of cellular organelles and signaling modules including Ca2+ signaling. As well, Ca2+ signals play important roles during progression through various stages of the cell cycle. A ubiquitous Ca2+ influx pathway that is activated based on intracellular Ca2+ store content is store-operated Ca2+ entry (SOCE). SOCE is activated through a complex interplay between a Ca2+ channel at the cell membrane, Orai1, and a Ca2+ sensor that localizes to the endoplasmic reticulum, STIM1. Herein, we discuss potential roles and regulation of STIM and Orai proteins during cellular proliferation.

Keywords
STIM
Orai
Cell Division
Cell Proliferation
Review
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