IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e378

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Immunoinformatics: how in silico methods are re-shaping the investigation of peptide immune specificity

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1 Singapore Immunology Network, 8A Biomedical Grove, No. 04-06 Immunos, Biopolis, Singapore 138648
2 Data Mining Department, Institute for Infocomm Research, 1 Fusionopolis Way, No. 21-01 Connexis South Tower, Singapore 138632
3 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597

*Author to whom correspondence should be addressed.

Academic Editor: Darja Kanduc

Front. Biosci. (Elite Ed) 2012, 4(1), 311–319; https://doi.org/10.2741/e378
Published: 1 January 2012
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)
Abstract

In the past decade, information technology has enabled synergistic advances in key domains of immunological research including the development of diagnostics and vaccines. Computational methods of epitope mapping now play instrumental roles in bench experiments, by facilitating the selection of immunogenic targets and the modeling of downstream cellular responses. In this article, we summarize the latest development and application of immune epitope prediction methods and discuss future directions in this field which could enhance our understanding of immune specificity.

Keywords
Bioinformatics
Immunoinformatics
Immunological Databases
T-cell epitope prediction
B-cell Epitope Prediction
Ig
immunoglobulin
TR: T-cell receptor
Review
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