IMR Press / FBE / Volume 15 / Issue 2 / DOI: 10.31083/j.fbe1502010
Open Access Original Research
Determination of Vitamin B12 and Folate Compounds in Commercially Available Edible Seaweed Products
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1 Division of Applied Bioresource Chemistry, The United Graduate School of Agricultural Sciences, Tottori University, 680-8553 Tottori, Japan
2 Department of Agricultural Science, Graduate School of Sustainability Science, Tottori University, 680-8553 Tottori, Japan
3 Department of Agricultural, Life, and Environmental Sciences, Faculty of Agriculture, Tottori University, 680-8553 Tottori, Japan
*Correspondence: (Fumio Watanabe)
Front. Biosci. (Elite Ed) 2023, 15(2), 10;
Submitted: 28 December 2022 | Revised: 30 January 2023 | Accepted: 22 February 2023 | Published: 5 May 2023
(This article belongs to the Special Issue Seaweed Applications in Food and Biotechnology)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Information on the contents of both vitamin B12 and folate in edible seaweeds is limited, of which deficiencies disrupt methionine biosynthesis to accumulate homocysteine as a risk factor of cardiovascular diseases. Methods: Both vitamins were determined in commercially available edible seaweed products using high-performance liquid chromatography. Results: Dried purple laver (Neopyropia yezoensis) products contain higher levels of vitamin B12 (approximately 30–60 μg/100 g dry weight) and folate compounds (approximately 880–1300 μg/100 g dry weight) than other seaweed products, such as kombu (Saccharina japonica), hijiki (Sargassum fusiformis), and wakame (Undaria pinnatifida). 5-methyltetrahydrofolate was the major folate compound in purple laver products. 5-formyltetrahydrofolate was found at a moderate level, whereas tetrahydrofolate, 5,10-metenyltetrahydrofolate, 10-formyltetrahydrofolate, and folic acid were found to be minor folate compounds. Conclusions: These findings suggest that dried purple laver (nori) products are suitable sources of vitamin B12 and folate compounds for humans, especially vegetarians.

edible seaweeds
purple laver
vitamin B12
Fig. 1.
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