IMR Press / FBL / Volume 24 / Issue 8 / DOI: 10.2741/4787

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Biologic response of sperm and seminal plasma to transient testicular heating
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1 Key Laboratory of Birth Regulation and Control Technology of National Health and Family Planning Commission of China, Key Laboratory for Improving Birth Outcome Technique, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong 250014, China
2 Shandong Provincial Hospital Affiliated to Shandong University, China
3 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
4 University of Chinese Academy of Sciences, Beijing, 100049, China
*Correspondence: (Yi Qiu)
Front. Biosci. (Landmark Ed) 2019, 24(8), 1401–1425;
Published: 1 June 2019
(This article belongs to the Special Issue Advances in mammalian reproduction)

Currently, there are few male contraceptive methods that are purely based on prevention of the entry of the sperm into the female reproductive tract. An alternative approach for designing reversible male contraceptive is achieved by transient testicular heating (TTH). This treatment, through massive germ cell apoptosis, causes reversible oligospermia or azoospermia. Here, we describe as how TTH causes DNA damage, oxidative stress, apoptosis, autophagy, sperm protein expression, and alters the biochemical components of seminal plasma. Further understanding of TTH will help design safe and reversible male contraception.

Transient scrotal heating
Sperm protein
Figure 1.
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