IMR Press / FBL / Volume 24 / Issue 8 / DOI: 10.2741/4786

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Sterile induction of innate immunity in Drosophila melanogaster
Show Less
1 Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan
2 Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia
3 Faculty of Pharmacy, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
*Correspondence: (Takayuki Kuraishi)
Front. Biosci. (Landmark Ed) 2019, 24(8), 1390–1400;
Published: 1 June 2019
(This article belongs to the Special Issue Cutting edge of insect biomedical science)

In the past decades, much has been learned about the protective signatures of innate immune responses during the course of infections. However, it is now evident that induction of immune effectors also commonly occurs in the absence of pathogenic cues. Such an event, termed sterile inflammation, has been linked to several debilitating acute and chronic host conditions. Using Drosophila melanogaster as a simple yet powerful model organism, identification of diverse sets of damage-associated molecular patterns and their corresponding surface and/or inside pattern recognition receptors on the cells, as well as elucidation of their significant roles in the host physiology and pathological conditions related to sterile inflammation, have been continuously reported. In addition, revelation of non-pathogenic molecular triggers leading to the orchestration of unnecessary activation of inflammatory responses has been a subject of interest. Here, we review decades of efforts to elucidate the molecular mechanisms responsible in the emergence of sterile inflammation. The characterization of the respective contributing factors, including recent demonstration of pinching as a novel sterile-stimuli in Drosophila, is also discussed.

Innate Immunity
Sterile Inflammation
Antimicrobial peptides
Figure 1.
Back to top