IMR Press / FBL / Volume 28 / Issue 9 / DOI: 10.31083/j.fbl2809221
Open Access Review
Advances in Cardiac Organoids
Yu-Hong Wang1,2,3,†Qing Ouyang1,4,†Shuang Zhao1,5Yue Zhang1,2,3Run-Ze Tian1,4Yan-Ping Guo1,4Rui Zheng1,2Moussa Ide Nasser2,3Ge Li1,2,3,4,*Ping Zhu1,2,3,4,5,*
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1 Department of Cardiac Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Cardiovascular Institute, 510100 Guangzhou, Guangdong, China
2 Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080 Guangzhou, Guangdong, China
3 Guangzhou Key Laboratory of Cardiac Pathogenesis and Prevention, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080 Guangzhou, Guangdong, China
4 School of Medicine, South China University of Technology, 510006 Guangzhou, Guangdong, China
5 School of Medicine, Jishou University, 416000 Jishou, Hunan, China
*Correspondence: lige@gdph.org.cn (Ge Li); zhuping@gdph.org.cn (Ping Zhu)
These authors contributed equally.
Front. Biosci. (Landmark Ed) 2023, 28(9), 221; https://doi.org/10.31083/j.fbl2809221
Submitted: 7 March 2023 | Revised: 28 April 2023 | Accepted: 18 May 2023 | Published: 25 September 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Cardiovascular diseases rank as the leading cause of death worldwide and are a major contributor to disability, posing a significant threat to human health. Organoids offer a partial simulation of the structure and function of the tissue of origin. It is a promising model that can supplement the disadvantages of two-dimensional culture and animal models. Due to the complexity of heart development, the research of cardiac organoids is still maturing. The advancement of technology has helped address certain challenges, but it has also unveiled new issues and complexities. This paper summarizes the application of organoids technology in the cardiovascular field, the common construction methods of cardiac organoids, and the latest progress of cardiac organoids in the fields of disease model construction, cardiac development research, drug research, and regenerative medicine. The future development and challenges of cardiac organoids are also addressed.

Keywords
stem cells
cardiac organoids
tissue engineering
self-assembly
self-organization
disease model
Funding
82271395/National Natural Science Foundation of China
82001301/National Natural Science Foundation of China
2022B1212010010/Science and Technology Planning Project of Guangdong Province
2023A1515030073/Guangdong Basic and Applied Basic Research Foundation
KD0120230024/Youth Talent Two-way Exchange Project of Guangdong and Macao
KY0120220133/Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital
DFJHBF202111/Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital
KJ012020630/Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital
DFJH201812/Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital
KJ012019423/Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital
Figures
Fig. 1.
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