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- Academic Editor
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†These authors contributed equally.
Background: Vascular endothelial dysfunction is an early phenotype of
aging-related vascular dysfunction. Delaying vascular aging and preventing
cardiovascular disease are major public health problems that urgently need to be
solved. Scientists have studied various drugs to prevent the occurrence and
progress of cardiovascular disease, but progress has been slow. Here, the
antisenescence and anti-endothelial damage of canthaxanthin (CX, which is an
active molecule from food) has been studied. Methods: This study was
performed by adding CX to a model of cell senescence and oxidative damage induced
by hydrogen peroxide. Cellular senescence markers (e.g., p16, p21, and p53) and
oxidative damage markers (e.g., reactive oxygen species, nitric oxide,
malondialdehyde, superoxide dismutase) were evaluated by the enzyme-linked
immunosorbent assay, laser scanning confocal microscopy, and Western blotting.
Results: We found that CX downregulated the expression level of
senescence-associated molecules, and significantly reduced the oxidative damage
of vascular endothelial cells. These observations showed that CX effectively
alleviated the senescence of vascular endothelial cells. Furthermore, CX
treatment reduced the expression levels of interleukin-6 (IL-6), tumor necrosis
factor alpha, and IL-1