Background: Humans are exposed to physical, biological, chemical, and
psychological stressor throughout their life span. In recent years many medicinal
plants have been shown to induce stress adapting and protective functions.
Plant-derived extracts and vitamin E exhibit stress protection or resistance by
normalizing cellular homeostasis and enhancing resistance to toxic stimuli to
overcome cellular damage. Here we report the evaluation of a topical preparation
(product test materials; PTM) containing an ingredient blend of Rhodiola Rosea,
Eleutherococcus Senticosus (Siberian Ginseng), Rhaponticum Carthamoides, Inonotus
Obliqus, and Slegainella Lepidophylla as the base formula and tested the addition
of Lespedeza Capitata (leaf/stem) extract plus vitamin E and/or Aloe Vera to
determine the induced protective functions in human skin when challenged with
intrinsic and extrinsic stressors. Methods: The base topical preparation
plus Lespedeza Capitata extract plus vitamin E or the base topical preparation
plus vitamin E and Aloe Vera were assayed in vitro on (a) intrinsically
stressed excised abdominoplasty skin, (b) full thickness (FT) skin equivalent
models post-treated with a combination of ultra-violet (UV) B light (250
mJ/cm
Announcements
Open Access
Original Research
Plant-Derived Extracts Plus Vitamin E and/or Aloe Vera Protect Against Intrinsic/Extrinsic Stressor in Human Skin: In Vitro and Clinical Evidence
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1
Center for Anti-Aging Research, Global Product Research and Development, Nu Skin Enterprises, Provo, UT 84601-4432, USA
2
Dermatology Consulting Services, PLLC, High Point, NC 27265-8501, USA
*Correspondence: gdiwakar@nuskin.com (Ganesh Diwakar)
Front. Biosci. (Landmark Ed) 2023, 28(12), 366;
https://doi.org/10.31083/j.fbl2812366
Submitted: 18 June 2023 | Revised: 12 October 2023 | Accepted: 30 October 2023 | Published: 29 December 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
product test materials
adaptogen ingredients
diesel particulate matter
UVB
full thickness skin equivalent models
Graphical Abstract
Funding
Nu Skin Enterprises
Figures
Fig. 1.