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Cellular Senescence in Non-Small Cell Lung Cancer
Huangkai Zhu1,*,†, Jiaen Sun2,†, Chong Zhang2,†, Pei Li1, Chuntao Tan3, Minglei Yang1, Guofang Zhao1,*
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1
Department of Thoracic Surgery, Ningbo No.2 Hospital, 315010 Ningbo, Zhejiang, China
2
Health Science Center, Ningbo University, 315211 Ningbo, Zhejiang, China
3
Department of Cardiac and Vascular Surgery, Ningbo No.2 Hospital, 315010 Ningbo, Zhejiang, China
*Correspondence: zhuhuangkai21280@163.com (Huangkai Zhu); zhaoguofang@ucas.edu.cn (Guofang Zhao)
†These authors contributed equally.
†These authors contributed equally.
Front. Biosci. (Landmark Ed) 2023, 28(12), 357;
https://doi.org/10.31083/j.fbl2812357
Submitted: 21 April 2023 | Revised: 28 July 2023 | Accepted: 8 August 2023 | Published: 28 December 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Lung cancer has the highest mortality rate amongst all malignancies worldwide, and is the second-highest incidence of cancer in women. Non-small cell lung cancer (NSCLC) is responsible for approximately 80% of lung cancer cases. Recent studies indicate that cellular senescence may be a promising cancer biomarker. However, the regulation of cellular senescence and its underlying mechanisms in NSCLC are not yet fully understood. Here, we present a comprehensive analysis of the genes linked to cellular senescence in NSCLC. We also describe the secretory phenotype associated with NSCLC and examine its immune profile and prognostic potential. Our findings offer novel insights into the development of effective NSCLC treatments.
Keywords
cellular senescence
non-small cell lung cancer
Graphical Abstract
Funding
PPXK2018-05/Ningbo Health Branding Subject Fund
2023J316/Ningbo Natural Science Foundation
2022KY1138/Medical Scientific Research Foundation of Zhejiang Province
CX2022006/Science and technology innovation guidance fund project of Hangzhou Medical College
2022HMKY37/HwaMei Reasearch Foundation of Ningbo No.2 Hospital
2023HMKY20/HwaMei Reasearch Foundation of Ningbo No.2 Hospital
2023HMKY32/HwaMei Reasearch Foundation of Ningbo No.2 Hospital
2022030208/Ningbo Top Medical and Health Research Program
LHDMD23H160001/Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China
2022BC078/China University Industry-University-Research Innovation Fund