- Academic Editor
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Background: Amyotrophic lateral sclerosis (ALS) is a systemic disease
with multiple pathological effects, including neuroinflammation, oxidative
stress, autophagy, mitochondrial dysfunction, and endoplasmic reticulum stress.
Despite many studies seeking to identify and develop effective therapies,
effective ALS treatment has yet to be approved. Hence, patients with ALS
ultimately experience muscle atrophy and loss of motor neurons. Herbal medicines
have been used to treat numerous diseases by modulating multiple biological
processes and exerting pharmacological effects, including anti-inflammatory and
antioxidant properties. In particular, Chaenomeles sinensis Koehne (CS)
exhibits anti-hyperuricemic and nephroprotective effects and is used to treat
anaphylaxis, viral infections, and neurodegenerative diseases, such as
Alzheimer’s disease. This study monitored the effects of CS supplementation on
muscle function and motor neurons in hSOD1