Identification of Key Novel lncRNAs RP11-400N13.3 and RP11-197K6.1 that Construct ceRNA Networks Associated with Recurrence and Metastasis in Colon Cancer

Identification of Key Novel lncRNAs RP11-400N13.3 and RP11-197K6.1 that Construct ceRNA Networks Associated with Recurrence and Metastasis in Colon Cancer

Yan Wang^1,†, Xing-hai Zhang^1,2,†, Si-hua Xie^1,†, Lu-lu Yang¹, En-yu Xu³, Jing-wei Liang^1,4,*, Fan-hao Meng^1,*

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¹ School of Pharmacy, China Medical University, 110052 Shenyang, Liaoning, China

² Department of Clinical Research Center, Central Hospital Affiliated to Shandong First Medical University, 250021 Jinan, Shandong, China

³ School of Forensic Medicine, China Medical University, 110052 Shenyang, Liaoning, China

⁴ School of Pharmacy, Hainan Medical University, 571100 Haikou, Hainan, China

^*Correspondence: hy0207147@hainmc.edu.cn (Jing-wei Liang); fhmeng@cmu.edu.cn (Fan-hao Meng)
^†These authors contributed equally.

Front. Biosci. (Landmark Ed) 2023, 28(10), 276; https://doi.org/10.31083/j.fbl2810276

Submitted: 22 March 2023 | Revised: 9 June 2023 | Accepted: 29 June 2023 | Published: 31 October 2023

This is an open access article under the CC BY 4.0 license.

Abstract

Background: Colon adenocarcinoma (COAD) is a major cause of cancer mortality worldwide. The occurrence and development of colon cancer is regulated by complex mechanisms that require further exploration. Recently, long non-coding RNAs (lncRNAs) were found to be related to the mortality of colon cancer patients through their participation in competing endogenous RNA (ceRNA) networks. Therefore, screening the lncRNAs involved in colon cancer may contribute to clarifying the complex mechanisms. Methods: In this study, we explored the potential lncRNAs associated with colon cancer by establishing a ceRNA network using bioinformatics, followed by biological verification. Results: RP11-197K6.1 and RP11-400N13.3 were screened out owing to their involvement in the expression of CDK2NA, a gene that potentially prevents colon cancer cells from high oxygen levels. Conclusions: Our work explored the mechanisms of recurrence and metastasis in colon cancer and provided potential targets for drug development.

Keywords

colon cancer

RP11-197K6.1

RP11-400N13.3

intracellular signaling

ceRNA network

Funding

82103998/National Natural Science Foundation of China for Young Scholars

Liaoning R&D [2019]26/Key Research and Development project of Liaoning

Figures

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