IMR Press / FBL / Volume 27 / Issue 10 / DOI: 10.31083/j.fbl2710280
Open Access Original Research
Characterization of the Intestinal Microbiome in Healthy Adults over Sars-Cov-2 Vaccination
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1 Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, China
2 Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, China
*Correspondence: dongying91@foxmail (Ying Dong); (Jing Li)
These authors contributed equally.
Academic Editor: Rosa Alduina
Front. Biosci. (Landmark Ed) 2022, 27(10), 280;
Submitted: 29 July 2022 | Revised: 24 August 2022 | Accepted: 2 September 2022 | Published: 8 October 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: In response to the outbreak of coronavirus disease 2019 (COVID-19) worldwide, inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are implemented. Dysbiosic gut microbiota is implicated in the COVID-19 patients. Whereas, how intestinal microbiota are affected by vaccination remains elusive, and it is important to investigate the microbial shifts during vaccines treatment. Methods: In the present study, we assessed the gut microbial composition in healthy adults, and performed comparison before and post an inactivated SARS-CoV-2 vaccine candidate, BBIBP-CorV vaccination. Results: Microbial diversity in shannon, pielou evenness, simpson and invsimpson index was remarkably suppressed by vaccination. Ruminococcus and Actinomyces were observed to be strikingly deficient, and Faecalibacterium was dramatically augmented after BBIBP-CorV treatment. Potential functional profiles of gut microbiome in amino acid metabolism, lipid biosynthesis proteins and steroid biosynthesis were remarkably increased, while the capacity in renin-angiotensin system was remarkably decreased following vaccines. Conclusions: Our study suggests that inactivated BBIBP-CorV against SARS-CoV-2 could elicit modulations on gut microbial composition and functions, which might favor host immune response and protect from COVID-19.

gut microbiota
Fig. 1.
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