IMR Press / FBL / Volume 27 / Issue 10 / DOI: 10.31083/j.fbl2710281
Open Access Review
The Role of Intestinal Flora in Anti-Tumor Antibiotic Therapy
Show Less
1 Department of Basic Medical Sciences, Shulan International Medical College, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Zhejiang Shuren University, 310015 Hangzhou, Zhejiang, China
2 State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, 310058 Hangzhou, Zhejiang, China
*Correspondence: (Xiaoling Xu)
These authors contributed equally.
Academic Editors: Sarah Shigdar and Maryam Nakhjavani
Front. Biosci. (Landmark Ed) 2022, 27(10), 281;
Submitted: 26 May 2022 | Revised: 23 June 2022 | Accepted: 1 August 2022 | Published: 8 October 2022
(This article belongs to the Special Issue Anticancer Drugs)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Anti-tumor antibiotics are chemical substances produced by micro-organisms to control cancer development. Some of the currently used cancer treatment regimens are anti-tumor antibiotics. However, many studies have demonstrated that anti-tumor antibiotics may have adverse effects on normal cells. This calls for development of strategies to alleviate these negative effects and improve cancer treatment. Recent studies have suggested that the efficacy of anti-tumor antibiotics may be affected by intestinal microbiota. For instance, intestinal microbiota can alleviate the negative effects of antibiotic treatment and regulate the tumor immune micro-environment. In this way, anti-tumor antibiotics can improve tumor control. However, the specific mechanisms need to be further explored. This review discusses the effect of intestinal flora on anti-tumor antibiotic therapy and summarizes the specific mechanisms by which antibiotics inhibit harmful intestinal micro-organisms and promote efficacy of probiotics, which may improve the control of neoplasm development and growth.

anti-tumor antibiotics
intestinal flora
tumor immune
2018YFC2000500/National Key Research and Development Program of China
2022R005/university level scientific research project of Zhejiang Shuren University
2018R006/university level scientific research project of Zhejiang Shuren University
2021R421015/Zhejiang Province New Young Talent Plan
Fig. 1.
Back to top