IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4295

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
From neurogenesis to neuroprotection in the epilepsy: signalling by erythropoietin
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1 Cellular and Molecular Biology Dept., CUCBA, University of Guadalajara, Zapopan, Jal. Mexico
2 Traumatology Dept, County Carmen´s Hospital, Guadalajara, Jalisco, Mexico
Academic Editor:Antoni Camins
Front. Biosci. (Landmark Ed) 2014, 19(8), 1445–1455; https://doi.org/10.2741/4295
Published: 1 June 2014
(This article belongs to the Special Issue Current advances in epilepsy and neurodegeneration)
Abstract

Epilepsy is a disorder characterised by recurrent seizures and molecular events, including the activation of early expression genes and the post-translational modifications of functional proteins. These events lead to changes in neurogenesis, mossy fibre sprouting, network reorganisation and neuronal death. The role of these events is currently a matter of great debate, especially as they relate to protection, repair, or further brain injury. In recent years, accumulating data have supported the idea that erythropoietin (EPO) regulates biological processes including neuroprotection and neurogenesis in several diseases, such as epilepsy. This review summarises the role of EPO in some of the molecular mechanisms involved in these events that could direct a more detailed approach for its use as a therapeutic alternative in reducing epileptic seizures.

Keywords
Epileptic hippocampus
Neurogenesis
Erythropoietin
Cell signalling
Neuroprotection
Review
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