IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4281

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Role of IFN-gamma in immune responses to Candida albicans infections

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1 Departamento de Microbiología y Ecología, Universitat de València, 46100 Burjassot, Valencia, Spain
2 Departamento de Optica, Farmacología y Anatomía, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante, Spain
Academic Editor:Nina Luisa Ivanovska
Front. Biosci. (Landmark Ed) 2014, 19(8), 1279–1290; https://doi.org/10.2741/4281
Published: 1 June 2014
(This article belongs to the Special Issue Role of IFN-gamma in immune responses to candida albicans infections)
Abstract

Candida albicans is the most frequent etiologic agent that causes opportunistic fungal infections called candidiasis, a disease whose systemic manifestation could prove fatal and whose incidence is increasing as a result of an expanding immunocompromised population. Here we review the role of interferon-gamma (IFN-γ) in host protection against invasive candidiasis. This cytokine plays an essential role in both the innate and adaptive arms of the immune response to candidiasis. We focus on recent progress on host-pathogen interactions leading to the production of IFN-γ by host cells. IFN-γ is produced by CD4 Th1, CD8, γδ T, and natural killer (NK) cells, essentially in response to both IL-12 and/or IL-18; more recently, a subset of C. albicans-specific Th17 cells have been described to produce both IL-17 and IFN-γ. IFN-γ plays an important role in the regulation of the immune system as well as in the control of the infectious process, as it is required for optimal activation of phagocytes, collaborates in the generation of protective antibody response, and favors the development of a Th1 protective response.

Keywords
Candida albicans
Candidiasis
Infection
IFN-gamma
Review
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