IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2831

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Cerebral vasoconstriction after subarachnoid hemorrhage - Role of changes in vascular receptor phenotype 

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1 Dept. of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
2 Glostrup Research Institute, Glostrup Hospital, Copenhagen University Hospital, Glostrup, Denmark
3 Department of Medicine, Lund University Hospital, Lund, Sweden
Academic Editor:John Zhang
Front. Biosci. (Landmark Ed) 2008, 13(6), 2160–2164; https://doi.org/10.2741/2831
Published: 1 January 2008
(This article belongs to the Special Issue New frontiers in neurosurgery research)
Abstract

The pathological constriction of cerebral arteries known as cerebral vasospasm (CVS) is with a delay of 4 to 10 days linked to subarachnoid hemorrhage. Several agents have been suggested as being responsible; amongst these perhaps 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1) are the most prominent given their ability to elicit powerful constriction of cerebral arteries. Investigating both 5-HT and ET receptors we have observed that there are distinct changes in receptor phenotype after experimental SAH, namely upregulation of the ETB and 5-HT1B receptors, and that this upregulation is linked to a higher sensitivity to the endogenous agonists. It has also been shown that reduction in regional cerebral blood flow (CBF) is associated with receptor upregulation and interventional animal experiments have shown a benefit from inhibiting the PKC and MAP kinase pathways on receptor upregulation, CBF and neurological outcome.

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