IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2830

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The promise of artificial liver replacement
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1 Tissue Engineering and Organ Fabrication Laboratory, Massachusetts General Hospital,185 Cambridge Street Suite 4.809 Boston, MA 02446

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(6), 2140–2159;
Published: 1 January 2008

One of the most challenging clinical syndromes in medicine is that of acute liver failure (ALF). Many devices and systems have been devised to support ALF patients. This manuscript reviews the significant clinical findings of ALF, as well as, the non-biologic liver support systems and the bioartificial liver devices that have been clinically tested to support patients with this disease. Finally, we identify several improvements critical to the future of the field of bioartificial liver replacement therapy.

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