IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2832

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

"Replacement of diseased auditory neurons by cell transplantation"
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1 Departments of Otolaryngology, Head and Neck Surgery
2 Establishment of International Center of Excellence (COE) for Integration of Transplantation Therapy and Regenerative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(6), 2165–2176;
Published: 1 January 2008

The auditory nerve is an important target in hearing restoration research along with the hair cells. Although there are several potentially useful therapeutic options to rebuild lost hearing, cell transplantation is a very realistic option. Cells can be infused into the auditory nerve without compromising the auditory brainstem responses and damaging the membranous labyrinth. The final fate of transplanted cells may be determined by the intrinsic molecular program and the extracellular guidance cues. The first factor may be largely decided by the type of donor cell used and the second factor can be modified by the application of various molecules. Our recent experiments using ontogenetic-stage/region-restricted precursors and embryonic stem cells suggest that donor cells at later development stages seemed to have more mature intrinsic molecular programs to guide them more precisely and efficiently to the final expected destination. We discuss the critical interactions between the extracellular molecules such as myelin-derived inhibitory molecules expressed after CNS injury and the intracellular actin dynamics regulated by Rho GTPases in relation to the regeneration of the auditory neurons.

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