IMR Press / FBE / Volume 4 / Issue 7 / DOI: 10.2741/E556

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


The role of micronutrients in the diet of HIV-1-infected individuals

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1 Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Catania, Italy
2 Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA
3 Department of Pediatrics and Pediatric Neurology, Azienda Ospedaliera Universitaria OVE-Policlinico, University of Catania, Catania, Italy
4 Department of Medical Oncology, National Cancer Institute, Aviano, PN, Italy
5 Department of Biomedical Science, University of Catania, Via Androne 83, Catania, Italy
6 Institute of Food Science and Nutrition, Università Cattolica Sacro Cuore, Via Emilia Parmense 84, Piacenza, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2012, 4(7), 2442–2456;
Published: 1 June 2012

Vitamins, zinc and selenium are important micronutrients that play crucial functions at the cellular and molecular level. Immune response of several different cell types can be modulated by these micronutrients. Deficiency in micronutrients has been extensively reported in HIV-1-infected individuals and further correlated with CD4+ T-cell count, HIV-1 plasma viral load, disease progression and mortality. Supplementation by micronutrients has had controversial effects. Thorough future investigations and trials are certainly needed to strategically plan evidence-based interventions. Here, we review the available data on use of micronutrients during the course of HIV-1 infection.

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