IMR Press / FBE / Volume 4 / Issue 6 / DOI: 10.2741/e535

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The neuroprotective effects of apocynin

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1 Department of Biochemistry, University of Missouri, Columbia, MO
2 Center for Translational Neurosciences, University of Missouri, Columbia, MO
3 Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO

Academic Editor: Albert Y. Sun

Front. Biosci. (Elite Ed) 2012, 4(6), 2183–2193; https://doi.org/10.2741/e535
Published: 1 January 2012
Abstract

The recognition of health benefits of phytomedicines and herbal supplements lead to an increased interest to understand the cellular and molecular basis of their biological activities. Apocynin (4- hydroxy-3-methoxy-acetophenone) is a constituent of the Himalayan medicinal herb Picrorhiza kurroa which is regarded as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, a superoxide-producing enzyme. NADPH oxidase appears to be especially important in the modulation of redoxsensitive signaling pathways and also has been implicated in neuronal dysfunction and degeneration, and neuroinflammmation in diseases ranging from stroke, Alzheimer’s and Parkinson’s diseases to psychiatric disorders. In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies.

Keywords
Apocynin
NADPH oxidase
NOX2
Neurodegeneration
Animal models
Review
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