IMR Press / FBE / Volume 4 / Issue 6 / DOI: 10.2741/e533

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Matrix metalloproteinases in T cell mediated pulmonary diseases

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1 Department of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
2 Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

*Author to whom correspondence should be addressed.

Academic Editor: Alexander Sasha Krupnick

Front. Biosci. (Elite Ed) 2012, 4(6), 2162–2169;
Published: 1 January 2012
(This article belongs to the Special Issue Recent advances in experimental lung biology)

Lung transplantation is the only conclusive treatment for many patients suffering from end-stage pulmonary disease. Unfortunately, the leading cause of death in lung transplant recipients is the development of chronic rejection known as obliterative bronchiolitis, characterized by extensive remodeling. Matrix metalloproteinases (MMPs) are endopeptidases known for their role in matrix remodeling and their involvement in many biological processes including end-stage pulmonary disease and transplant rejection. Our understanding of MMPs involvement in pulmonary immunity is rapidly expanding. As a result there has been some focus on MMPs role in T cell-associated pulmonary diseases, such as pulmonary fibrosis, emphysema, asthma and bronchiolitis obliterans syndrome. However, not much is known about the role of MMPs in regulating immune cell function. It is now commonly known that MMP inhibition via, broad spectrum or specific synthetic or naturally occurring inhibitors (TIMPs) can down regulated many pulmonary disease states. In this review, we explore the idea that T cell targeted MMP inhibition may provide a novel approach of immune regulation in the treatment of T cell-mediated diseases.

Matrix metalloproteinases
Lung transplantation
T cells
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