IMR Press / FBE / Volume 4 / Issue 6 / DOI: 10.2741/e527

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer’s disease

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1 Deptartment of Cell Biology and Neuroscience, Nelson Biological Laboratories, 604 Allison Road, Piscataway, NJ 0854

Academic Editor: Agata Copani

Front. Biosci. (Elite Ed) 2012, 4(6), 2101–2109; https://doi.org/10.2741/e527
Published: 1 January 2012
(This article belongs to the Special Issue Alzheimer's disease)
Abstract

Alzheimer’s disease is a neurodegenerative disorder that accounts for the majority of the dementia in individuals over the age of 65. While much has been learned about the biology and biochemistry of the tau tangles and beta-amyloid plaques, less is known about the cell biology of the neuronal cell death process. This review examines one feature of this process, the unexpected occurrence of unscheduled cell cycle events in mature and normally non-mitotic neurons in the at-risk neuronal populations. The correlation of neuronal cell cycling and cell death is not unique to Alzheimer’s, but the evidence in both human Alzheimer’s disease and its mouse models suggests that these events are early disease related processes, that they are driving forces of the disease rather than indirect symptoms. Defining the biochemistry behind cell cycle initiation holds promise as a fresh therapeutic approach in the battle against this devastating disease.

Keywords
Alzheimer's disease
Neuron
Nerve
Central nervous system
Review
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